Colorectal cancer metastases to the thyroid gland: A case report

Hernández, Patricia Ciriano; Pinedo, Carlos Martínez; Alises, Enrique Calcerrada; Santos, Esther García; García, Susana Sánchez; Rodríguez, Rafael Picón; Higuera, Elisa Jiménez; Peláez, Daniel Sánchez; Montoro, Violeta Herrera; Fernández, Jesús Martín

doi:10.4240/wjgs.v12.i3.116

Cited by 8 publications

(6 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with thyroid metastases can be asymptomatic or present with goiter-related symptoms, such as the presence of a neck mass, neck edema, dysphagia, and hoarseness [2]. It is noteworthy that the majority of thyroid metastases (72-75%) are symptomatic, like in our patient, which is in agreement with the existing literature [13].…”

Section: Discussionsupporting

confidence: 91%

“…The incidence of thyroid metastasis from all tumor types ranges between 1.2% and 24%, with the most common primary sites being the lungs, kidneys, and breast, followed by gastrointestinal neoplasms, melanomas, and lymphomas [1,2]. This low incidence is attributed to the rich and fast arterial flow through the gland, as well as to high values of oxygen and iodine, which would prevent the adhesion and growth of tumor cells [3,4].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Rare Case of Thyroid Metastasis From Colorectal Cancer: Diagnostic and Therapeutic Challenges

Lampropoulou,

Pliakou,

Panagiotou

et al. 2023

Cureus

View full text Add to dashboard Cite

The incidence of thyroid metastases among patients suffering from primary colorectal cancer is rare, and only a few cases have been described in the literature. As these metastases are usually asymptomatic, they most frequently present as incidentalomas on follow-up imaging. Hereby, we present and discuss an interesting case of metastatic sigmoid adenocarcinoma of the thyroid gland, diagnosed and treated at our institution.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

A Rare Case of Thyroid Metastasis From Colorectal Cancer: Diagnostic and Therapeutic Challenges

Lampropoulou,

Pliakou,

Panagiotou

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…1 The common metastatic sites of colorectal cancer include the liver and lung, but metastasis to the thyroid is rare. The thyroid metastatic carcinoma accounts for 1.4-3% of all thyroid carcinomas, 2 which is much less than the ratio of 1.9-9.5% detected during autopsies. 3 Several theories have been developed to explain the mechanisms that contribute to the rarity of thyroid gland metastatic deposits, including failure of cellular adhesion due to rapid arterial blood flow and inhibition of tumor cell growth by high iodine concentrations.…”

Section: Introductionmentioning

confidence: 79%

Sign of Neck Mass as the Chief Complaint: A Case Report and Literature Review About Thyroid Metastasis of Colorectal Cancer

Wang,

Pei

et al. 2024

CMAR

View full text Add to dashboard Cite

“…There were 10 females and 4 males, and the mean age was 61 years. One patient reported by Mennet et al had a multinodular goitre and another patient reported by Hernandez et al had sub-clinical hypothyroidism, whereas the others did not have associated thyroid pathology [ 4 , 5 ]. Four patients were incorrectly suspected of having papillary thyroid cancer on cytologic evaluation of fine needle aspiration (FNA) sample.…”

Section: Introductionmentioning

confidence: 99%

Colorectal cancer metastases in thyroid: case report and literature review

2023

View full text Add to dashboard Cite

Background The thyroid gland is an uncommon site for metastatic deposits from non-thyroid malignancies, occurring in only 1.4 - 3% of surgical specimens where malignancy is suspected. It is even rarer for the source of thyroid metastases to be of colorectal origin. In most cases reported, colorectal metastases in the thyroid occurs many years later after the primary colorectal cancer has been diagnosed and treated. In this unique case, a primary sigmoid carcinoma metastasised to the thyroid gland and presented synchronously as a thyroid nodule. Case presentation We describe a case of a 64-year-old Caucasian woman who presented with clinical features of metastatic cancer of unknown origin. Her medical history included underlying hyperthyroidism. She had a large pelvic mass adjacent to the sigmoid colon, a left lower lobe lung mass and a suspicious nodule in the left thyroid lobe. A fine-needle aspiration biopsy of the thyroid nodule was performed, which remarkably showed malignant cells originating from primary colorectal cancer on immunohistochemical staining. The patient was managed with palliative chemotherapy given the poor prognosis due to disseminated colorectal malignancy. Conclusions Colorectal adenocarcinoma metastases can rarely present as a metastatic thyroid nodule. Fine-needle aspiration should be performed in suspicious thyroid nodules and may be the least invasive way of identifying a metastatic colorectal or other non-thyroidal malignancy in patients presenting with an unknown primary. The pathologist should be vigilant to this possibility and specific immunohistochemical markers should be used to ensure accurate diagnosis. In thyroid metastases, the prognosis is ultimately determined by the primary tumour but thyroidectomy still has a role in alleviating compressive symptoms and can potentially improve survival in selected cases.

show abstract

Colorectal cancer metastases to the thyroid gland: A case report

Cited by 8 publications

References 13 publications

A Rare Case of Thyroid Metastasis From Colorectal Cancer: Diagnostic and Therapeutic Challenges

A Rare Case of Thyroid Metastasis From Colorectal Cancer: Diagnostic and Therapeutic Challenges

Sign of Neck Mass as the Chief Complaint: A Case Report and Literature Review About Thyroid Metastasis of Colorectal Cancer

Colorectal cancer metastases in thyroid: case report and literature review

Contact Info

Product

Resources

About