Colorectal cancer OncoGuia

Walsh, Paula Manchon; Borrás, Josep María; Ferro, Tàrsila; Espinàs, Josep Alfons

doi:10.1007/s12094-010-0489-5

Cited by 10 publications

(4 citation statements)

References 196 publications

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“…Among this subgroup, 1/3 presented normal histology at the first resection and cell damage at the second. Two cases presented an onset of steatosis, and four cases vascular lesions, possibly due to the addition of oxaliplatin 19 .…”

Section: Discussionmentioning

confidence: 97%

“…The design of the present study did not distinguish between the group exposed to the preoperative chemotherapy and the group exposed to the adjuvant regimens with primary colorectal tumor resection. These tumors, when in stages II and III, have indications for regimens based on 5-fluorouracil + leucovorin for six months 19 , which explains the predominance of this protocol and the steatosis as a histological pattern of injury.…”

Section: Discussionmentioning

confidence: 99%

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The association between preoperative chemotherapy and the prevalence of hepatic steatosis in hepatectomy for metastatic colorectal cancer

Kalil¹,

Coral²,

Santos³

et al. 2014

ABCD, arq. bras. cir. dig.

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BackgroundSome studies have suggested that preoperative chemotherapy for hepatic colorectal metastases may cause hepatic injury and increase perioperative morbidity and mortality.AimTo evaluate the prevalence of hepatic steatosis in patients undergoing preoperative chemotherapy for metastatic colorectal cancer.MethodsObservational retrospective cohort study in which 166 patients underwent 185 hepatectomies for metastatic colorectal cancer with or without associated preoperative chemotherapy from 2004 to 2011. The data were obtained from a review of the medical records and an analysis of the anatomopathological report on the non-tumor portion of the surgical specimen. The study sample was divided into two groups: those who were exposed and those who were unexposed to chemotherapy.ResultsFrom the hepatectomies, 136 cases (73.5%) underwent preoperative chemotherapy, with most (62.5%) using a regimen of 5-fluorouracil + leucovorin. A 40% greater risk of cell damage was detected in 62% of the exposed group. The predominant histological pattern of the cell damage was steatosis, which was detected in 51% of the exposed cases. Exposure to chemotherapy increased the risk of steatosis by 2.2 fold. However, when the risk factors were controlled, only the presence of risk of hepatopathy was associated with steatosis, with a relative risk of 4 (2.7-5.9).ConclusionPatients exposed to chemotherapy have 2.2 times the risk of developing hepatic steatosis, and its occurrence is associated with the presence of predisposing factors such as diabetes mellitus and hepatopathy.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

The association between preoperative chemotherapy and the prevalence of hepatic steatosis in hepatectomy for metastatic colorectal cancer

Kalil¹,

Coral²,

Santos³

et al. 2014

ABCD, arq. bras. cir. dig.

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“…The OncoGuies published in this issue and the last issue (Colon and Rectal Cancer OncoGuia [3], Breast Cancer OncoGuia [4] and Lung Cancer OncoGuia [5]) were fi rst published in November 2003 [6][7][8].…”

Section: Updatementioning

confidence: 99%

Clinical practice guidelines in cancer in Catalonia: process and methodology

Walsh¹,

Borrás²,

Ferro³

et al. 2010

Clin Transl Oncol

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“…

The guidelines below have been developed in the framework of the Colorectal Cancer OncoGuia [1] and are aimed at standardising descriptions of diagnoses in colorectal cancer pathology reports so that these are fully comparable regardless of the pathologist who issues the diagnosis [2-6].

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mentioning

confidence: 99%