Colorectal cancer presenting as bone metastasis

Babu, M C Suresh; Garg, Sunny; Lakshmaiah, K C; Babu, K Govind; Kumar, Rekha V.; Dasappa, Lokanatha; Abraham, Linu Jacob; Rajeev, L K; Lokesh, K.; Rudresha, A H; Rao, Suparna Ajit

doi:10.4103/0973-1482.181177

Cited by 21 publications

(10 citation statements)

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“…A retrospective study with 10 patients with CRC presented as bone metastases reported by Babu et al [ 4 ], tried to rule out some common features among those cases, but only in three of them the bone metastases were solitary. They detected that the most affected bones were vertebras and pelvis.…”

Section: Discussionmentioning

confidence: 99%

“…It is historically recognized that CRC has a determined pattern of dissemination. The liver is the most affected organ in 60% of the cases, followed by abdominal lymph nodes and lungs [ 4 ]. In contrast, metastases in other organs such as adrenals, brain, bones or skin, are less frequent and commonly occur in the context of a widespread disease with multifocal affection, or a relapse after a primary treatment.…”

Section: Introductionmentioning

confidence: 99%

“…The incidence of bone metastases is reported to be around 5%–23% [ [3] , [4] , [5] , 7 ]. The predisposition for this uncommon metastatic site may be attributed to the pattern of blood flow (connected to the location of the primary CRC) or to molecular protein signals.…”

Section: Introductionmentioning

confidence: 99%

“…The predisposition for this uncommon metastatic site may be attributed to the pattern of blood flow (connected to the location of the primary CRC) or to molecular protein signals. Most of the patients develop these metastases through the course of the disease, accompanied by extra-bone lesions; however, solitary bone metastases rarely take place at the initial diagnosis [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Colon adenocarcinoma first presenting as shoulder pain. Case report

Gonçalves

Díez-Alonso

Moraza

et al. 2020

International Journal of Surgery Case Reports

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Highlights CRC is one of the top causes of death in high-income countries. Colorectal primary tumours mostly disseminate to liver, lungs and peritoneum. Bone metastases rarely belong to the unique and curable metastases group of patients. Isolated colorectal cancer bone metastases are rare and usually associated with better prognosis. Careful study of the behaviour of rare types of colonic tumours is essential to progress in scientific knowledge.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Colon adenocarcinoma first presenting as shoulder pain. Case report

Gonçalves

Díez-Alonso

Moraza

et al. 2020

International Journal of Surgery Case Reports

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“…In addition, gender and age are among the factors related to poor survival, Babu et al presented a clinical study in which CRC patients with bone metastases were male and young. However, whether sex affects the prognosis of these subjects needs to be deeply investigated [17].…”

Section: Crc and Bone Metastasesmentioning

confidence: 99%

Colorectal Cancer and Bone Tissue: Fantastic Relations and Where to Find Them

Gigante

Tutino

Nunzio

et al. 2020

Cancers

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Colorectal cancer (CRC) is the third most common cancer worldwide. There is a need for the early diagnosis of CRC for a better prognostic outcome. It is, therefore, crucial to understand the CRC pathogenesis in all its aspects. In many cases, one of the main causes of cancer-related deaths is the presence of metastases. In this context, an often overlooked aspect is the metastatic tropism, since CRC, like other cancers, is more prone to metastasize some organs rather than others. Beyond the liver and lung, and differently from other types of cancers, a not usual site of CRC metastases is the bone. However, it may assume a crucial role in the development and the outcome of the disease. Therefore, this review aims to discuss the complex relations between bone markers and CRC pathogenesis, suggesting the use of these molecules as potential targets for therapeutic purposes. Different osteogenic molecules, some of whom are growth factors and are implicated in the different osteogenic pathways, have been proved to also be involved in CRC progression. Some of them are oncogenes, while others oncosuppressors, and in a future perspective, some of them may represent new potential CRC biomarkers.

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When accurate cytomorphology directs clinical decision: Colonic adenocarcinoma presents initially with an isolated vertebral bone metastasis

Asiry

Matloob

Gera

2020

Diagnostic Cytopathology

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Liver is the most common site for metastasis of colonic adenocarcinoma. Other relatively common metastatic locations include: peritoneum, lungs and ovaries. Rare metastatic sites include: central nervous system, testis, uterus, oral cavity and bones. Though it is rare to have an isolated bone metastasis without liver or visceral involvement in colonic adenocarcinoma, it can occur. Our case illustrates the vital role of an accurate cytopathologic diagnosis in directing the proper clinical decision and management in our young patient. Our patient's first presentation was acute on chronic back pain radiating to his lower extremities with clinical suspicion of tuberculosis spondylitis. The correct cytopathologic diagnosis of the fine needle aspiration from the destructive vertebral lesion led to the establishment of an isolated metastatic colonic adenocarcinoma diagnosis initially and directed the clinical management of our patient.

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Colorectal cancer presenting as bone metastasis

Cited by 21 publications

References 0 publications

Colon adenocarcinoma first presenting as shoulder pain. Case report

Colon adenocarcinoma first presenting as shoulder pain. Case report

Colorectal Cancer and Bone Tissue: Fantastic Relations and Where to Find Them

When accurate cytomorphology directs clinical decision: Colonic adenocarcinoma presents initially with an isolated vertebral bone metastasis

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