Colorectal cancer risk in East Asian patients with Helicobacter pylori infection: A systematic review and meta-analysis

Ma, Lijuan; Guo, Wentao; Zeng, Zhihui; Yang, Fei; Tang, Shufang; Ling, Yarui

doi:10.1097/md.0000000000033177

Cited by 4 publications

(2 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hp is an infectious gram-negative pathogenic bacterium that can be transmitted through fecal-oral, oral-oral, and gastric-oral routes, and the incidence of H. pylori infection varies from region to region and from lifestyle to lifestyle [9] .The inflammatory substances, lipase proteins and toxic substances secreted by Hp can damage the gastric barrier leading to chronic gastritis, peptic ulcer, gastric cancer and extra-gastrointestinal diseases [10] . In recent years, it was reported that the prevalence of Hp infection was positively correlated with the prevalence of hypertension in Chinese adults [11,12] , which is a risk factor for cardiovascular and ocular diseases, while H. pylori infection can increase homocysteine levels [4,13,14] , which in turn is an important risk factor for cardiovascular and cerebrovascular pathogenesis, as well as an independent risk factor for osteoporosis In addition, the poor living conditions, irregular living habits, and stressful life of workers make them more likely to be infected with Hp and highly susceptible to related diseases, therefore, workers should be considered as a key concern, so it is urgent to study the risk factors of H. pylori infection and H hypertension.…”

Section: Discussionmentioning

confidence: 99%

Analysis of influencing factors associated with Hp infection in H-type hypertension

2023

AJMHS

View full text Add to dashboard Cite

Objective to investigate the influencing factors of Helicobacter pylori (Hp) infection in patients with H type hypertension. Methods A total of 1089 patients with h-type hypertension who underwent physical examination in Lanzhou PetrochemicalCompany of petrochina in Lanzhou city, Gansu Province from May 2021 to September 2021 were selected as the research objects. All the patients were tested by 14C urea breath test and divided into Hp infected group (278 cases) and Hp non-infected group (811 cases) according to the test results. For collected age, sex and other general demographic indicators and determined systolic blood pressure (SBP) diastolic blood pressure (DBP) albumin (ALB) globulin (GLB) total protein (TP) albumin/globulin (ALB/GLB) uric acid (UA) triglyceride (TG) Total cholesterol (TC) High-density lipoprotein (HDL) Low density lipoprotein (LDL) fasting blood glucose (GLU) and other biochemical indicators were analyzed by univariate analysis and multivariate unconditiona Logistic regression analysis. Results Univariate analysis showed that albumin (ALB) in h-type hypertension patients in infection group was lower than that in lung infectiongroup, and the difference was statistically significant (T =3.383, P<0.05). Systolic blood pressure (SBP), globulin (GLB), triglyceride (TG) and fasting blood glucose (GLU) were higher than those in the non-infected group, but the differences were not statistically significant (ALL P>0.05). Diastolic blood pressure (DBP), total protein (TP), uric acid (UA), total cholesterol (TC) and low density lipoprotein (LDL) were higher than those in the non-infected group. There were no significant differences (all P>0.05); Multivariate non-conditional Logistic regression showed that high density lipoprotein (DHL) was an independent protective factor for Hp infection in h-type hypertension patients (OR=0.49, P<0.05). Conclusions Hp infection is associated with lipid metabolism disorder, and high density lipoprotein is a protective factor of HELICobacter pylori infection in patients with H type hypertension.

show abstract

Section: Discussionmentioning

confidence: 99%

Analysis of influencing factors associated with Hp infection in H-type hypertension

2023

AJMHS

View full text Add to dashboard Cite

show abstract

“…Over the past three decades, our understanding of Helicobacter pylori ( H. pylori ) has significantly advanced, revealing its association with various extragastric disorders encompassing gastrointestinal tumors, 1–3 hepatobiliary diseases, 4,5 respiratory system diseases, 6 cardiovascular diseases, 7,8 metabolic disorders, 9 and hematologic diseases 10 . This association can be attributed to the chronic and persistent nature of H. pylori infection, which induces chronic inflammation and immune responses.…”

Section: Introductionmentioning

confidence: 99%

Interactions between Helicobacter pylori infection and host metabolic homeostasis: A comprehensive review

Ye,

Feng,

et al. 2023

Helicobacter

View full text Add to dashboard Cite

The microbiota actively and extensively participates in the regulation of human metabolism, playing a crucial role in the development of metabolic diseases. Helicobacter pylori (H. pylori), when colonizing gastric epithelial cells, not only induces local tissue inflammation or malignant transformation but also leads to systemic and partial changes in host metabolism. These shifts can be mediated through direct contact, toxic components, or indirect immune responses. Consequently, they influence various molecular metabolic events that impact nutritional status and iron absorption in the host. Unraveling the intricate and diverse molecular interaction links between H. pylori and human metabolism modulation is essential for understanding pathogenesis mechanisms and developing targeted treatments for related diseases. However, significant challenges persist in comprehensively understanding the complex association networks among H. pylori itself, the infected host's status, the host microbiome, and the immune response. Previous metabolomics research has indicated that H. pylori infection and eradication may selectively shape the metabolite and microbial profiles of gastric lesions. Yet, it remains largely unknown how these diverse metabolic pathways, including isovaleric acid, cholesterol, fatty acids, and phospholipids, specifically modulate gastric carcinogenesis or affect the host's serum metabolism, consequently leading to the development of metabolic‐associated diseases. The direct contribution of H. pylori to metabolisms still lacks conclusive evidence. In this review, we summarize recent advances in clinical evidence highlighting associations between chronic H. pylori infection and metabolic diseases, as well as its potential molecular regulatory patterns.

show abstract

Fecal Immunochemical Test and Helicobacter pylori Stool Antigen Co-Testing

Camargo

2024

JAMA

View full text Add to dashboard Cite

Gastric cancer is a leading cause of cancer death globally. Although endoscopy-based screening has led to a decrease in gastric cancer mortality in Eastern Asian countries with populations at high risk, 1 lack of risk stratification and the cost of health care infrastructure and trained personnel limit its use in most of the world. Availability of noninvasive biomarkers for the identification of high-risk individuals could optimize endoscopy-based screening programs for a more general application, including in regions where gastric cancer rates in the general population are low.Chronic Helicobacter pylori infection is responsible for at least 80% of gastric cancers globally, 2 including approximately 90% of noncardia (ie, distal) tumors and at least 50% of cardia tumors. 3,4 H pylori infection is also etiologically linked to peptic ulcer and extragastric conditions, including iron deficiency anemia. According to the US Surveillance, Epidemiology, and End Results (SEER) Program, the estimated number of new cases of gastric cancer that will be diagnosed in the US population in 2024 is 26 890. There are racial and ethnic disparities in gastric cancer in the US; incidence rates are 2-to 3-fold higher in self-identified African American, Asian, and Hispanic/Latino populations compared with non-Hispanic White populations. Unfortunately, most US patients with gastric cancer are diagnosed at advanced stages, when curative resection is not possible. The 5-year relative survival in the US SEER dataset for the 2014-2020 period is only 36.4%, much lower than in Japan or the Republic of Korea.Results from several randomized trials show that H pylori eradication reduces both gastric cancer incidence and mortality by about 40%. 5 Similar benefits of H pylori eradication are observed in first-degree relatives of patients with gastric cancer 6 and after resection of early gastric cancer to prevent metachronous gastric cancer. 7 Additionally, H pylori test-and-treat strategies in adults could be cost-effective as a primary screen in some settings. 8 The International Maastricht VI/Florence consensus designated as a priority the implementation of policies for diagnosis and treatment of H pylori in populations with intermediate rates (ie, 10-20 per 100 000 population, agestandardized) to high rates (ie, >20 per 100 000 population) of gastric cancer, using antibiotic regimens achieving at least 90% eradication rates. 8 These primary prevention efforts should be conducted in the context of demonstration projects to be later scaled and integrated into national health care systems.Although no recent population-based data of H pylori infection are available in the US, studies in convenience sample sets suggest that like gastric cancer, long-standing racial and ethnic

show abstract

Colorectal cancer risk in East Asian patients with Helicobacter pylori infection: A systematic review and meta-analysis

Cited by 4 publications

References 27 publications

Analysis of influencing factors associated with Hp infection in H-type hypertension

Analysis of influencing factors associated with Hp infection in H-type hypertension

Interactions between Helicobacter pylori infection and host metabolic homeostasis: A comprehensive review

Fecal Immunochemical Test and Helicobacter pylori Stool Antigen Co-Testing

Contact Info

Product

Resources

About