Colorectal Cancer Screening Based on Age and Gender: A Cost-effectiveness Analysis

Wong, Martin C.S.; Chan, Victor; Shum, Jeffrey P.; Ching, Jessica; Ng, Simon Siu Man; Lam, Thomas Y.; Luk, Arthur K.C.; Wong, Sunny H.; Ng, Siew C.; Wu, Justin C.Y.; Chan, Francis K.L.; Sung, Joseph J.Y.

doi:10.1016/j.cgh.2015.04.067

Cited by 8 publications

(10 citation statements)

References 31 publications

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“…However, the effectiveness and cost‐effectiveness of this approach have not been evaluated fully 19 . As several recent studies have suggested that tailored CRC screening based on background factors of screened individuals may improve cost‐effectiveness, it is hypothesized that CRC screening using a risk score is beneficial in terms of effectiveness, cost‐effectiveness, and burden on the CS capacity 20–22 …”

Section: Introductionmentioning

confidence: 99%

Cost‐effectiveness analysis of colorectal cancer screening using colonoscopy, fecal immunochemical test, and risk score

Sekiguchi

Igarashi

Sakamoto

et al. 2020

J of Gastro and Hepatol

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Background and Aim: A risk-stratification score may be useful for colorectal cancer (CRC) screening, alongside screening colonoscopy (CS) and fecal immunochemical test (FIT). This study aimed to evaluate the effectiveness and cost-effectiveness of population-based CRC screening strategies using CS, FIT, and the Japanese CRC screening score. Methods: The effectiveness in quality-adjusted life years (QALYs), cost-effectiveness, and required number of CS procedures were evaluated for screening strategies with primary screening CS (strategy 1), FIT (strategy 2), and the risk score (strategy 3), using a simulation model analysis with two scenarios. In scenario 1, uptake rates for all tests were 60%. In scenario 2, uptake rates for FIT and a risk score were 40%, and those for screening CS and CS following a positive FIT or high risk score were 20% and 70%, respectively. Results: In scenario 1, strategy 1 gained the highest QALYs and required the highest cost. The incremental cost-effectiveness ratios per QALY gained for strategy 1 against the others were lower than 5 000 000 JPY. Strategy 1 required more than twice as many CS procedures as the other strategies. In scenario 2, strategy 3 had the highest QALYs and lowest cost, and strategy 1 had the lowest QALYs and highest cost. Conclusions: Screening CS has the potential to be the most effective and cost-effective form of CRC screening, although it requires a large number of CS procedures. However, if non-invasive tests are preferred by recipients, other screening strategies, particularly those using the risk score, can be more effective and cost-effective. Cost-effectiveness of colon screening M Sekiguchi et al.

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Section: Introductionmentioning

confidence: 99%

Cost‐effectiveness analysis of colorectal cancer screening using colonoscopy, fecal immunochemical test, and risk score

Sekiguchi

Igarashi

Sakamoto

et al. 2020

J of Gastro and Hepatol

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“…Molecular pathogenesis of CRC is complicated and poorly understood. Several risk factors are associated with CRC progression, including aging, genetic aberrations, and chronic intestinal inflammation (2). Although CRC-related oncogenic factors have been extensively studied, the underlying mechanisms remains to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

“…MicroRNAs (miRNA), 19-22 nucleotide non-coding RNA molecules, have been identified as key negative regulators of gene expression by binding to the 3'-untranslated regions (UTR) of the target mRNAs of protein-coding genes, resulting in mRNA cleavage or the inhibition of mRNA translation (3). Accumulating evidence suggested that miRNAs regulate the expression of genes involved in several important cancer-related processes including cell adhesion, proliferation, apoptosis and tumorigenesis, including colorectal cancer (2). Zhang et al has reported that miR-520a-3p could suppressed colorectal cancer cell migration via the regulation of EGFR expression (4).…”

Section: Introductionmentioning

confidence: 99%

miR‑1273g‑3p promotes proliferation, migration and invasion of LoVo cells via cannabinoid receptor 1 through activation of ERBB4/PIK3R3/mTOR/S6K2 signaling pathway

Qian

Zhu

et al. 2018

Mol Med Report

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MicroRNAs (miR) are important in various crucial cell processes including proliferation, migration and invasion. Dysregulation of miRNAs have been increasingly reported to contribute to colorectal cancer. However, the detailed biological function and potential mechanisms of miR‑1273g‑3p in colorectal cancer remain poorly understood. The expression levels of miR‑1273g‑3p in human colorectal cancer LoVo cell lines were detected via reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). The target genes of miR‑1273g‑3p were predicted by bioinformatics and verified by a luciferase reporter assay, RT‑qPCR and western blotting. The MTT, wound‑healing and Transwell assays were used to examine the biological functions of miR‑1273g‑3p in LoVo cells. The potential molecular mechanisms of miR‑1273g‑3p on LoVo cell proliferation, migration and invasion was detected by western blotting. The results of the present study demonstrated that miR‑1273g‑3p expression was extensively upregulated in LoVo cells compared with the normal colon epithelial NCM460 cell line. Further studies indicated that miR‑1273g‑3p inhibitor significantly suppressed LoVo cell proliferation, migration and invasion compared with inhibitor control. Following this, the cannabinoid receptor 1 (CNR1) was identified as a direct target gene of miR‑1273g‑3p. Knockdown of CNR1 restored the phenotypes of LoVo cells transfected with miR‑1273g‑3p inhibitor. Furthermore, the potential molecular mechanism of miR‑1273g‑3p on LoVo cell proliferation, migration and invasion may be mediated by activating the Erb‑B2 receptor tyrosine kinase 4 (ERBB4)/phosphoinositide‑3‑kinase regulatory subunit 3 (PIK3R3)/mechanistic target of rapamycin (mTOR)/S6 kinase 2 (S6K2) signaling pathway. These observations indicated that miR‑1273g‑3p promoted the proliferation, migration and invasion of LoVo cells via CNR1, and this may have occurred through activation of the ERBB4/PIK3R3/mTOR/S6K2 signaling pathway, suggesting that miR‑1273g‑3p may serve as a novel therapeutic target for the effective treatment of colorectal cancer.

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“…Formal cost-effectiveness analysis based on various risk factors should be performed for each population to be served. [12][13][14] There are also concerns about the acceptability and distributive justice of such an approach. Whilst some unhealthy lifestyle habits such as smoking, drinking alcohol, and consuming red meat are risk factors for CRC, it is hard to justify why people 'choosing these lifestyle habits' deserve to be screened by a more expensive screening option such as colonoscopy.…”

mentioning

confidence: 99%

Challenges to the adoption of risk algorithms for colorectal cancer screening programmes: perspectives for future research

Huang¹,

Huang²

2017

Hong Kong Med J

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Colorectal Cancer Screening Based on Age and Gender: A Cost-effectiveness Analysis

Cited by 8 publications

References 31 publications

Cost‐effectiveness analysis of colorectal cancer screening using colonoscopy, fecal immunochemical test, and risk score

Cost‐effectiveness analysis of colorectal cancer screening using colonoscopy, fecal immunochemical test, and risk score

miR‑1273g‑3p promotes proliferation, migration and invasion of LoVo cells via cannabinoid receptor 1 through activation of ERBB4/PIK3R3/mTOR/S6K2 signaling pathway

Challenges to the adoption of risk algorithms for colorectal cancer screening programmes: perspectives for future research

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