Colorectal Cancer Screening: Impact of COVID-19 Pandemic and Possible Consequences

Harber, Isabelle; Zeidan, Dania; Aslam, Muhammad N.

doi:10.3390/life11121297

Cited by 23 publications

(21 citation statements)

References 36 publications

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“…With regard to colorectal neoplasias, the unprecedented burden of the pandemic on healthcare systems has led to a considerable reduction in the number of diagnostic and surveillance endoscopic procedures performed in the general population [ 23 , 24 ]. Recent reports indicate that such drastic changes in clinical practice are projected to lead to increased incidence and tumor stage upshifting as missed cancer cases keep accumulating, in turn increasing colorectal cancer-associated mortality [ 25 ]. The problem is further compounded by the encountered delays and postponements of elective colorectal surgical procedures [ 2 ], carrying severe implications regarding the long-term impact of the pandemic in the survival of colorectal cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Colorectal Surgery in the COVID-19 Era: A Systematic Review and Meta-Analysis

Παραράς

Pikouli

Papaconstantinou

et al. 2022

Cancers

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(1) Background: To determine the impact of the COVID-19 pandemic in the management of colorectal cancer patients requiring surgery and to examine whether the restructuring of healthcare systems led to cancer stage upshifting or adverse treatment outcomes; (2) Methods: A systematic literature search of the MedLine, Scopus, Web of Science, and CNKI databases was performed (PROSPERO ID: CRD42021288432). Data were summarized as odds ratios (OR) or weighted mean differences (WMDs) with 95% confidence intervals (95% CIs); (3) Results: Ten studies were examined, including 26,808 patients. The number of patients presenting with metastases during the pandemic was significantly increased (OR 1.65, 95% CI 1.02–2.67, p = 0.04), with no differences regarding the extent of the primary tumor (T) and nodal (N) status. Patients were more likely to have undergone neoadjuvant therapy (OR 1.22, 95% CI 1.09–1.37, p < 0.001), while emergency presentations (OR 1.74, 95% CI 1.07–2.84, p = 0.03) and palliative surgeries (OR 1.95, 95% CI 1.13–3.36, p = 0.02) were more frequent during the pandemic. There was no significant difference recorded in terms of postoperative morbidity; (4) Conclusions: Patients during the pandemic were more likely to undergo palliative interventions or receive neoadjuvant treatment.

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Section: Discussionmentioning

confidence: 99%

Colorectal Surgery in the COVID-19 Era: A Systematic Review and Meta-Analysis

Παραράς

Pikouli

Papaconstantinou

et al. 2022

Cancers

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“…The pandemic aftermath weighs heavily on any health system, extending the gap between the healthcare professionals and patients with a risk for colon cancer redistributing resources away from screening programs [ 71 ].…”

Section: Discussionmentioning

confidence: 99%

State-of-the-Art Review on Immersive Virtual Reality Interventions for Colonoscopy-Induced Anxiety and Pain

Găină

Szalontay

Ştefănescu

et al. 2022

JCM

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Background: Colonoscopy related fear impairs the current gold standard screening of colorectal cancer. Compared to other minimally invasive procedures for cancer screening, colonoscopy-induced anxiety exceeds the procedure through bowel preparation. Immersive virtual reality’s (iVR) role in alleviating the complex stress–pain relationship encountered during medical procedures is directly proportional to the rising affordability of state-of-the-art Head-Mounted-Displays (HMDs). Objective: to assess the effect of iVR on patients’ colonoscopy-induced anxiety and pain. Materials and methods: A systematic search was conducted in PubMed, Cochrane Central Register of Controlled Trials, Web of Science, Embase and Scopus databases up to January 2022. Clinical trials evaluating anxiety as an outcome were included without language restriction. Results: Four clinical trials were included: three on the patients’ intraprocedural anxiety and one on patient education. Intraprocedural iVR interventions for colonoscopy-induced anxiety and pain revealed a similar effect as conventional sedation, while a statistically significant reduction was reported for non-sedated patients. iVR patient education improved the quality of bowel preparation and reduced patient anxiety before colonoscopy. Conclusions: The current research highlights the need to use high-end HMDs and appropriate interactive iVR software content for colonoscopy-induced anxiety. Methodological frameworks regarding the eligibility of participants, double-blinding and randomization of iVR studies can facilitate the development of iVR implementation for anxiety and pain management.

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“…This was especially true during lockdown periods, when even access to hospitals was limited to urgent cases [3,4]. This has led to suboptimal and delayed management of all other diseases [5]. Oncological pathologies have been particularly affected, and delays have been documented in screenings, referrals, diagnoses, therapy, and follow-up [6].…”

Section: Introductionmentioning

confidence: 99%

Effect of COVID-19 Pandemic on Hepatocellular Carcinoma Diagnosis: Results from a Tertiary Care Center in North-West Italy

Ribaldone

Caviglia

Gaia³

et al. 2022

Current Oncology

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The COVID-19 pandemic has forced us to direct most of the available resources towards its management. This has led to the neglect of all other pathologies, including cancer. The aim of this study was to verify whether the difficulty in accessing the health system has led to a reduction in new diagnoses of hepatocellular carcinoma (HCC) and whether this has already been reflected in a more advanced stage of the cancer. A single-center, retrospective study including adult patients with a new diagnosis of HCC was performed. Patients were divided into three groups: the prelockdown phase (May 2019–February 2020), the lockdown phase (March 2020–December 2020), and the postlockdown phase (January 2021–October 2021); 247 patients were included. The number of patients diagnosed with HCC distinctly diminished in the periods March 2020–December 2020 (n = 69; −35%) and January 2021–October 2021 (n = 72; −32%) as compared to the period May 2019–February 2020 (n = 106). Noteworthy was the reduced surveillance in the period January 2021–October 2021 as compared to May 2019–February 2020 (22.9% vs. 36.6%, p = 0.056). No significant changes have yet been observed in tumor characteristics (BCLC staging distribution remained unvaried, p = 0.665). In conclusion, the number of new HCC diagnoses decreased sharply in the first 2 years of the pandemic, with no worsening of the stage. A more advanced stage of the disease could be expected in the next few years in patients who have escaped diagnosis.

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Colorectal Cancer Screening: Impact of COVID-19 Pandemic and Possible Consequences

Cited by 23 publications

References 36 publications

Colorectal Surgery in the COVID-19 Era: A Systematic Review and Meta-Analysis

Colorectal Surgery in the COVID-19 Era: A Systematic Review and Meta-Analysis

State-of-the-Art Review on Immersive Virtual Reality Interventions for Colonoscopy-Induced Anxiety and Pain

Effect of COVID-19 Pandemic on Hepatocellular Carcinoma Diagnosis: Results from a Tertiary Care Center in North-West Italy

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