Colorectal Cancer Screening in an Equal Access Healthcare System

DeBarros, Mia; Steele, Scott R.

doi:10.7150/jca.5833

Cited by 22 publications

(14 citation statements)

References 95 publications

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“…In addition, we did not look separately at the type of colorectal screening (fecal occult blood test [FOBT], sigmoidoscopy, colonoscopy, or barium enema). FOBT may be more common among non-whites and is a guideline recommended screening modality [44]. Finally, lower screening rates for cervical cancer among breast cancer survivors could be the result of higher total hysterectomy rates among the survivors as part of their cancer treatment.…”

Section: Discussionmentioning

confidence: 99%

Racial disparities in healthy behaviors and cancer screening among breast cancer survivors and women without cancer: National Health Interview Survey 2005

Yaghjyan

Wolin

Chang

et al. 2014

Cancer Causes Control

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Purpose We investigated racial disparities in healthy behaviors and cancer screening in a large sample from the US population. Methods This analysis used the data from 2005 National Health Interview Survey and included women at age ≥40 years who completed the cancer questionnaires (2,427,075 breast cancer survivors and 57,978,043 women without cancer). Self-reported information on cancer history, healthy behaviors (body mass index, smoking, alcohol use, physical activity, fruit/vegetable consumption, sunscreen use). We compared distributions of each factor among Caucasian, African American and Hispanic women with and without breast cancer history. Results Caucasian breast cancer survivors as compared to their cancer-free counterparts were less likely to be current smokers (8.3 vs.16.9%, p<0.001) and to have regular mammograms (51.5 vs.36.9%, p<0.05). Differences in associations between cancer survivors and respondents without cancer among African American and Hispanic women did not reach statistical significance. Conclusions Certain breast cancer survivor groups can benefit from tailored preventive services that would address concerns related to selected healthy behaviors and screening practices. However, most of the differences are suggestive and do not differ by race.

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Section: Discussionmentioning

confidence: 99%

Racial disparities in healthy behaviors and cancer screening among breast cancer survivors and women without cancer: National Health Interview Survey 2005

Yaghjyan

Wolin

Chang

et al. 2014

Cancer Causes Control

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“…1,2 Epidemiological statistics indicate that *1,360,000 new CRC cases will be diagnosed worldwide. Overall, the 5-year survival rates for patients with CRC are about 65%.…”

Section: Introductionmentioning

confidence: 99%

Abrogation of MUC5AC Expression Contributes to the Apoptosis and Cell Cycle Arrest of Colon Cancer Cells

ZhuXijia

LongXiangkai

LuoXishun

et al. 2016

Cancer Biotherapy and Radiopharmaceuticals

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Deregulated expressions of mucins have been found in various malignancies and play a pivotal role in carcinogenesis. MUC5AC, as a secreted mucin, is reported to be aberrantly expressed during epithelial cancer progression, including colon cancer. However, the mechanisms of the oncoprotein MUC5AC in the initiation of colon cancer requires further investigation. Here, we collected colon cancer tissues (n = 20) and corresponding paracancerous tissues (n = 20) and found that the expression of MUC5AC was significantly elevated in colon cancer tissues when compared with the corresponding paracancerous tissues. Immunofluorescence indicated that all colon cancer cell lines, including HT29, SW620, and the normal human intestinal epithelial cells FHC, showed the positive expression of MUC5AC, and SW620 exhibited the highest expression. Moreover, knockdown of MUC5AC in SW620 cells remarkably suppressed cell vitality and promoted apoptosis and G1 cell cycle arrest, resulting in the impaired ability of colony formation. Furthermore, the inhibition of MUC5AC in SW620 cells dramatically repressed the cell migration and invasion. These results demonstrated that MUC5AC as an oncogene could be a promising target in the treatment of colon cancer.

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“…Colorectal cancer (CRC) represents the third most common cancer in men and the second most common cancer in women globally (1–3). With the development of early diagnosis and treatment modalities, the 5-year survival rate of CRC has been improved over the past two decades (2,4).…”

Section: Introductionmentioning

confidence: 99%

miR-217 regulates tumor growth and apoptosis by targeting the MAPK signaling pathway in colorectal cancer

Zhang

Chen

2016

Oncology Letters

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MicroRNA (miR)-217 has been reported to participate in carcinogenesis and tumor progression in several cancers; however, its expression and biological functions in colorectal cancer (CRC) are still unclear. The present study demonstrated that miR-217 expression was significantly higher in matched adjacent noncancerous tissues than in CRC tissues (P<0.001). In addition, it was observed that low-grade CRC exhibited greater expression of miR-217 compared with high-grade CRC (P<0.05). Kaplan-Meier survival and Cox regression analyses revealed that overall survival rates were significantly poorer in the low-expression group relative to the high-expression group (P<0.005). Next, a potential miR-217 target, mitogen-activated protein kinase (MAPK) 1, was identified. Upregulation of miR-217 could significantly downregulate MAPK1 expression. CRC cells overexpressing miR-217 exhibited cell growth inhibition by significant enhancement of apoptosis in vitro. The present study further investigated the MAPK signaling pathway to verify the mechanisms, and revealed that KRAS and Raf-1 expression was downregulated in miR-217-overexpressing RKO cells. Taken together, our results revealed that miR-217 inhibits tumor growth and enhances apoptosis in CRC, and that this is associated with the downregulation of MAPK signaling. These results indicate that miR-217 is a promising therapeutic target for the treatment of CRC.

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Colorectal Cancer Screening in an Equal Access Healthcare System

Cited by 22 publications

References 95 publications

Racial disparities in healthy behaviors and cancer screening among breast cancer survivors and women without cancer: National Health Interview Survey 2005

Racial disparities in healthy behaviors and cancer screening among breast cancer survivors and women without cancer: National Health Interview Survey 2005

Abrogation of MUC5AC Expression Contributes to the Apoptosis and Cell Cycle Arrest of Colon Cancer Cells

miR-217 regulates tumor growth and apoptosis by targeting the MAPK signaling pathway in colorectal cancer

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