Colorectal Cancer Screening With Repeated Fecal Immunochemical Test Versus Sigmoidoscopy: Baseline Results From a Randomized Trial

Comparative Effectiveness of Fecal Immunochemical Tests versus Flexible Sigmoidoscopy for Colorectal Cancer Screening: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

“…All the studies were randomized, population-based clinical trials. The cut-offs for FIT positivity varied across the studies: 100 μg/g for Segnan et al [18], 20 μg/g for Hol et al [19], 15 μg/g for Castells et al [20] & Randel et al [22] and 10 μg/g for Grobbee et al [21]. The characteristics of the included studies are shown in Table I.…”

“…Blinding of participants and personnel was not possible, which is usually the scenario in endoscopy studies, and therefore could lead to performance bias. All the studies had low risk of attrition bias except for Randel et al [22]. Castells et al [20] extrapolated sigmoidoscopy results from colonoscopy.…”

“…However, the analysis was limited by a large number of studies utilizing gFOBT which has largely been replaced by FIT now. Several studies have since then evaluated FIT and compared it to flexible sigmoidoscopy as a screening technique for CRC [18][19][20][21][22]. We hereby present a systematic review and meta-analysis of randomized trials comparing detection and participation rates of FIT and flexible sigmoidoscopy in CRC screening.…”

Cancer screening at the level of state programs: review, recommendations and management

“…Колоноскопия в качестве первичного метода скрининга сейчас изучается в нескольких рандомизированных исследованиях, где она сравнивается с тестом на скрытую кровь в кале. Сигмоскопия больше распространена в Скандинавских странах, однако последнее исследования показало, что с точки зрения приверженности скринингу тест на скрытую кровь эффективнее сигмоскопии [22]. Также было отмечено, что при повторном исследовании по результатам теста Раннее выявление заболеваний на скрытую кровь в кале выявляется больше полипов.…”

Merits, Challenges, and Limitations of Randomized Trials on Colorectal Cancer Screening Effectiveness

“…In this issue of Gastroenterology, results are presented from a Norwegian RCT including almost 140,000 participants that was designed to directly compare, for the first time, the effectiveness of FIT-based screening (4 biennial rounds of FIT) with once-only FS screening with respect to reduction of CRC mortality. 5 This Norwegian trial will provide most welcome and long-awaited evidence on the comparative performance of these 2 widely used screening strategies for CRC. In the design and sample size calculation, a decrease in CRC mortality (the primary end point) was assumed to be twice as great in the FS arm (30%) than in the FIT arm (15%).…”