Colorectal carcinoma in indeterminate colitis

Branco, Bernardino C.; Harpaz, Noam; Sachar, David B.; Greenstein, Alexander J.; Tabrizian, Parissa; Bauer, Joel J.; Greenstein, Adrian J.

doi:10.1002/ibd.20865

Cited by 12 publications

(7 citation statements)

References 33 publications

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“…A diagnosis of IBDU was considered when the morphology included overlapping features of ulcerative colitis (UC) and Crohn's disease (CD) regarded as inconsistent with either diagnosis (Branco et al, 2009), and all such cases were confirmed after discussions by pathologists, endoscopists, and clinicians. In this series, 261 cases were classified as UC, 189 cases as CD, and 27 cases as IBDU.…”

Section: Methodsmentioning

confidence: 99%

Inflammatory bowel disease unclassified

Zhou

Chen

et al. 2011

J. Zhejiang Univ. Sci. B

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Abstract:Objective: Inflammatory bowel diseases (IBDs) are idiopathic, chronic, and inflammatory intestinal disorders. The two main types, ulcerative colitis (UC) and Crohn's disease (CD), sometimes mimic each other and are not readily distinguishable. The purpose of this study was to present a series of hospitalized cases, which could not initially be classified as a subtype of IBD, and to try to note roles of the terms indeterminate colitis (IC) and inflammatory bowel disease unclassified (IBDU) when such a dilemma arises. Methods: Medical records of 477 patients hospitalized due to IBD, during the period of January 2002 to April 2009, were retrospectively studied in the present paper. All available previous biopsies from endoscopies of these patients were reanalyzed. Results: Twenty-seven of 477 IBD patients (5.7%) had been initially diagnosed as having IBDU. Of them, 23 received colonoscopy and histological examinations in our hospital. A total of 90% (9/10) and 66.7% (4/6) of patients, respectively, had a positive finding via wireless capsule endoscopy (CE) and double-balloon enteroscopy (DBE). The barium-swallow or small bowel follow-through (SBFT) was performed on 11 patients. Positive changes were observed under computer tomographic (CT) scanning in 89.5% (17/19) of patients. Reasonable treatment strategies were employed for all patients. Conclusions: Our data indicate that IBDU accounts for 5.7% of initial diagnoses of IBD. The definition of IBDU is valuable in clinical practice. For those who had no clear clinical, endoscopic, histological, or other features affording a diagnosis of either UC or CD, IBDU could be used parenthetically.

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Section: Methodsmentioning

confidence: 99%

Inflammatory bowel disease unclassified

Zhou

Chen

et al. 2011

J. Zhejiang Univ. Sci. B

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“…It is evident that the variations in the definitions for IBDU can be either too stringent or all encompassing, including as many permutations of the various features that cannot be classified as either UC or CD. [16][17][18] With such a varying background, it is not surprising that the mechanism of this conversion of IBDU to CD remains elusive and difficult to investigate. Finally, our results may reflect that as an IBD surgery team, we may be more aggressive in performing IPAA for IBDU as compared with other institutions especially because we did demonstrate that the long-term outcomes of the ileal pouch were similar in patients with UC or IBDU who underwent IPAA.…”

Section: Discussionmentioning

confidence: 98%

“…Referral center bias must be considered, and also our definition of patients with IBDU may differ from other IBD centers, which had reported different results. 14 We acknowledge the inherent problem of the lack of consensus on the definition of IBDU as a disease entity, [16][17][18][19] but as a tertiary IBD center, we have consistently used the above definition for our practice. In patients with a preoperative diagnosis of IBDU, it would not be unexpected that the rate of developing CD be higher than the estimated 1% to 10% reported in other series of patients that included both UC and IB-DU.…”

Section: Discussionmentioning

confidence: 99%

Clinical Factors Associated with the Development of Crohnʼs Disease in Inflammatory Bowel Disease-unclassified Patients Undergoing Ileal Pouch–anal Anastomosis

Koh

Zaghiyan

et al. 2016

Inflammatory Bowel Diseases

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“…They complaining from overlapping features of inflammatory bowel disease like Ulcerative Colitis (UC) and Crohn's Disease (CD) and confirmed by pathologists, endoscopists, and clinicians as non specific colitis. 10 Colonoscopy, upper gastrointestinal endoscopy, biopsies, serological tests, radiography, and other scanning procedures used for confirming diagnosis. The exclusion criteria were patients with proved UC, CD, malignancy and infectious colitis.…”

Section: Methodsmentioning

confidence: 99%

Obesity and helicobacter pylori infection in adults with non specific colitis

S.H.Al-Khalidy

2020

Journal of Coloproctology

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Background Non specific colitis is defined as inflammatory condition of the colon that when examined microscopically lacks any characteristic features of any specific form of colitis and is commonly seen in reports of colonoscopy biopsies. There are many factors that cause it like obesity and H pylori . Aim of the study To determine the association of obesity and H pylori as contributory factors to this disease. Patients and methods This is a case-controlled study was carried out in Al-Kindy College of Medicine from January 2017 to June 2018. Sixty individuals were included; forty of them had non specific colitis. The rest were healthy control group. Demographic information's were taken like age and sex. Anthropometric measurement like weight in kilograms (kg), height in meters (m), waist circumference in centimeters (cm), and body mass index was done. H pylori IgG was done to both groups. Results Study results indicated that this disease was more common with increasing age, there is a significant difference (p = 0.002) between patients (48.12 ± 1.50) and control group (41.00 ± 1.10) regarding age. BMI of the patients is significantly higher in patients group (29.21 ± 0.41; p = 0.000) than the control (22.23 ± 0.41). Patients with non specific colitis showed significant (p = 0.000) increased in H pylori infection 33 (82.5%) compared with control group 2 (10%). Conclusions Obesity and infection with H pylori may predispose to non specific colitis.

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Colorectal carcinoma in indeterminate colitis

Abstract: CRC in IC shares most of the clinical and pathologic features as well as survival outcomes with CRC that occurs in the most prevalent forms of inflammatory bowel disease (IBD), UC and CD. Surveillance regimens currently used in the other forms of IBD seem applicable to IC patients as well.

Cited by 12 publications

References 33 publications

Inflammatory bowel disease unclassified

Inflammatory bowel disease unclassified

Clinical Factors Associated with the Development of Crohnʼs Disease in Inflammatory Bowel Disease-unclassified Patients Undergoing Ileal Pouch–anal Anastomosis

Obesity and helicobacter pylori infection in adults with non specific colitis

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