“…It is important to note that endoscopically obtained biopsy material is superficial and endometriosis usually involves the deeper layers of the bowel wall [3,10,11,12]. Tissue obtained by endoscopy often reflects chronic injury but may lack diagnostic endometriotic foci which could introduce the potential for misinterpretation and misdiagnosis [6,12,[13][14][15][16]. In addition, the endometriotic implants can promote secondary mucosal changes, which may resemble differential diagnoses, such as ischemic colitis, inflammatory bowel disease, or even neoplasm [4,12,16].…”