Colorectal Hamartomatous Polyposis and Ganglioneuromatosis in a Dog

Bemelmans, Ingrid; Küry, Sébastien; Albaric, Olivier; Hordeaux, Juliette; Bertrand, L; Nguyen, Françoise; Abadie, Jérôme

doi:10.1177/0300985810384411

Cited by 18 publications

(35 citation statements)

References 13 publications

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Section: Introductionmentioning

confidence: 99%

“…Ganglioneuromatosis has been described in few dogs in the intestinal tract [5][6][7][8] and in the wall of the gallbladder [9]. It has so far been mostly reported in puppies and juveniles [5][6][7], rarely in adult dogs [8,9]. Reported clinical signs of ganglioneuromatosis include persistent diarrhea, intermittent vomiting, poor appetite, depression and poor body condition in small intestinal ganglioneuromatosis [6,8] and tenesmus, hematochezia and rectal prolapse in colorectal ganglioneuromatosis [5,7].…”

Section: Introductionmentioning

confidence: 99%

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Small Intestinal Ganglioneuromatosis Accompanied by an Ulcer in a 13-Year Old Dog

2020

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Ganglioneuromatosis is a rare disorder characterized by hyperplasia of intestinal ganglia including myenteric plexus and enteric nerve fibers. This disorder is generally described in children, but sporadic cases have also been described in adults. Most human cases arise in the colon and rectum. The disorder has also been described in dogs, mostly juveniles, but rarely in mature dogs with the oldest dog reported with this change being 9 years old.We report the first case in an older dog from Croatia. A 13-year old female, mixed-breed dog had a history of diarrhea and weight loss. Ultrasound revealed focally-extensive markedly thickened small intestine. The changed part of the intestine, measuring 7 mm x 20 mm, was removed on laparotomy and delivered for histopathologic examination. Grossly, the intestine showed circumferential expansion of the intestinal wall, which was whitish in color. Microscopic findings included diffuse hyperplasia of the myenteric and submucous plexus. Focally in the affected tissue a subacute ulcer was evident, which was probably not the cause of intestinal signs, as it presented a localized lesion, while ganglioneuromatosis was a diffuse change in the affected tissue.So far, ganglioneuromatosis was reported in young dogs, rarely in adult dogs. Our report shows that ganglioneuromatosis can also be encountered in older dogs. Although the lesion presents a rare finding, it should be listed as a differential diagnosis in dogs where infectious and neoplastic etiology has been ruled out as cause of diarrhea.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Small Intestinal Ganglioneuromatosis Accompanied by an Ulcer in a 13-Year Old Dog

2020

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“…In a 5-month-old Great Dane bitch, a 10-cm section of colorectal polyposis was removed, and it turned out to be hamartoma. In that animal, a mutation of PTEN was found, which makes the disease similar to Cowden syndrome in humans (1). In a 4-month-old kitten, gingival hamartoma was diagnosed, and what is interesting, the lesion was accompanied by hyperglycemia, which resolved after surgical removal of the tumor along with a part of the jaw.…”

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confidence: 96%

Hamartoma: a rare developmental disorder

Bartyzel¹,

Max²,

Gruszczyńska³

et al. 2017

Medycyna Weterynaryjna

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SummaryHamartoma is a developmental disorder of various body parts and organs. It is characterized by a nonneoplastic growth of tissue with an uneven distribution and proportion of individual cells. Lesions progress for several years, but usually do not give clinical symptoms, and do not undergo malignant transformation. They occur alone or coexist with other defects, sometimes forming a characteristic clinical picture of a syndrome of congenital defects. Mutations in genes, such as PTEN, GLI3, SDH B/D, PIK3CA and ACT1, cause a dysfunction of the tumor suppressor gene and result in an increased neoplastic transformation. Hamartoma is a lesion between developmental disorders and benign tumors, which occurs frequently in humans, but is very rare in domestic animals. In a histopathological examination, however, it is diagnosed relatively often. In the veterinary literature, both hamartoma and choristoma are attributed mostly to errors in embryogenesis and are not considered as preneoplastic lesions.

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“…A case of colorectal hamartomatous polyposis and ganglioneuromatosis with PTEN duplication affecting a Great Dane puppy was recently documented. In this case, similar to what occurs in human Cowden syndrome, a possible mutation was investigated in the PTEN gene; however, such mutation was not proven [19].…”

Section: Discussionmentioning

confidence: 92%

Gastric Smooth Muscle Hamartomas Mimicking Polyps in a Dog: A Case Description and a Review of the Literature

Taulescu

Amorim

Gärtner

et al. 2013

Case Reports in Veterinary Medicine

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This report presents a case of two smooth muscle hamartomas of the stomach in a 10-year-old male Boxer. The clinical history of the animal was of chronic vomiting, weight loss, and intermittent gastric distension, and it died because of chronic and congestive heart failure. Gross, histology, and immunohistochemistry (IHC) exams were performed. On necropsy, in the pyloric region of the stomach, two closely related polypoid growths between 10 and 15 mm in diameter were identified. On the cut sections, both polyps presented white to gray color, with homogenous architecture and well-defined limits. The thickness of the submucosal layer was seen to be increased to 1 cm. No other gastric alterations were identified by the necropsy exam. Histologically, both masses growth consisted of hyperplastic glands lined by foveolar epithelium, arranged in a papillary or branching pattern, and supported by a core of well-vascularised and marked smooth muscle tissue interspersed between glands. No dysplastic cells and mitotic figures were observed in these lesions. Immunohistochemistry revealed a strong cytoplasm labelling for smooth muscle actin of the bundles around the mucosal glands. To our knowledge, this is the first report of smooth muscle hamartomas mimicking multiple gastric polyps in dogs.

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Colorectal Hamartomatous Polyposis and Ganglioneuromatosis in a Dog

Cited by 18 publications

References 13 publications

Small Intestinal Ganglioneuromatosis Accompanied by an Ulcer in a 13-Year Old Dog

Small Intestinal Ganglioneuromatosis Accompanied by an Ulcer in a 13-Year Old Dog

Hamartoma: a rare developmental disorder

Gastric Smooth Muscle Hamartomas Mimicking Polyps in a Dog: A Case Description and a Review of the Literature

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