Colorectal polyp diagnosis: results with the second‐generation colon capsule (<scp>CCE</scp>‐2)

Rondonotti, Emanuele; Pennazio, Marco

doi:10.1111/codi.12819

Cited by 3 publications

(3 citation statements)

References 28 publications

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“…Capsule colonoscopy will be evaluated against optical colonoscopy and other non-invasive approaches, such as CT colonography and stool-based tests (eg, faecal immunochemical test (FIT) and DNA assays). 8 20 26 27 Currently, the niche for capsule colonoscopy in the US includes patients who are at elevated risk of complications from or decline standard screening, or who have had an incomplete colonoscopy—which may expand the pool of those screened for colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Initial US evaluation of second-generation capsule colonoscopy for detecting colon polyps

Morgan

Malik

Romeo

et al. 2016

BMJ Open Gastroenterol

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ObjectivesCapsule colonoscopy is an additional screening modality for colorectal cancer. Second-generation capsule colonoscopy (CC2) may have improved efficacy in the detection of colon adenomas as compared with prior devices. The purpose of this study was to evaluate the performance of CC2 in the detection of polyps in symptomatic and screening patients in the USA.DesignProspective, multicentre study.Setting and participantsTwo academic medical centres and two private practice facilities, evaluating patients with indications for colonoscopy.MethodsPatients underwent capsule colonoscopy procedure using magnesium citrate as a boost, followed by colonoscopy on the same day. The main outcome measurement was accuracy of CC2 for the detection of colorectal polyps ≥6 and ≥10 mm as compared with conventional colonoscopy.Results51 patients were enrolled, 50 of whom had CC2 and colonoscopy examinations and were included in the accuracy analysis. 30% and 14% of patients had polyps ≥6 and ≥10 mm, respectively. For lesions ≥10 mm identified on conventional colonoscopy, CC2 sensitivity was 100% (95% CI 56.1% to 100%) with a specificity of 93.0% (79.9% to 98.2%). For polyps ≥6 mm, the CC2 sensitivity was 93.3% (66.0% to 99.7%) and the specificity was 80.0% (62.5% to 90.9%). There was a 61% adequate cleansing rate with 64% of CC2 procedures being complete.ConclusionsIn the initial US experience with CC2 there was adequate sensitivity for detecting patients with polyps ≥6 mm in size. Magnesium citrate was inadequate as a boost agent.Trial registration numberNCT01087528.

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Section: Discussionmentioning

confidence: 99%

Initial US evaluation of second-generation capsule colonoscopy for detecting colon polyps

Morgan

Malik

Romeo

et al. 2016

BMJ Open Gastroenterol

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“…[1][2][3] Most studies on CCE have focused on its accuracy in comparison to the gold standard colonoscopy and on bowel preparation regimens. [1][2][3][4][5][6][7][8] These studies indicate that the accuracy of polyp detection in CCE is comparable to that of colonoscopy. In a recent clinical trial comparing the accuracy of CCE to colonoscopy 53 participants (21%) underwent a second colonoscopy to investigate 'false positive' polyps in CCE.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years colon capsule endoscopy (CCE) has emerged as a promising diagnostic technique to assess the colonic and rectal mucosa, for example as a possible filter test in colorectal cancer screening 1–3 . Most studies on CCE have focused on its accuracy in comparison to the gold standard colonoscopy and on bowel preparation regimens 1–8 . These studies indicate that the accuracy of polyp detection in CCE is comparable to that of colonoscopy.…”

Section: Introductionmentioning

confidence: 99%

Intra and inter‐observer agreement on polyp detection in colon capsule endoscopy evaluations

et al. 2018

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Background Colon capsule endoscopy is a promising technique for evaluation of the colon, but its reproducibility is still unknown. Objective This study assesses intra and inter-observer agreement in evaluations of colon capsule endoscopy videos. Methods Forty-two complete colon capsule endoscopy investigations were analysed by three experts and two beginners. Intra-observer agreement was assessed in paired readings of two experts and two beginners. Agreement was determined by the intraclass correlation coefficient: poor (<0.5), moderate (0.5–0.75), good (0.75–0.9) and excellent (>0.9). Results Agreement on ‘indication for a following colonoscopy’ based on the number and size of detected polyps and bowel cleansing quality was poor among all observers. Agreement among experts on the detection of large polyps and number of polyps was moderate, but agreement on bowel cleansing quality was poor. Beginners were in moderate agreement with the experts on polyp detection. Intra-observer agreement in experts was moderate to excellent for the detection of large polyps (≥10 mm), excellent for the number of polyps, and poor to moderate for bowel cleansing quality. Intra-observer agreement in beginners was poor to moderate for all variables. Conclusions This study shows a poor agreement on ‘indication for a following colonoscopy’, but a high intra and inter-observer agreement for polyp detection among experts, as well as a moderate agreement between beginners and experts. Trial registration: NCT02303756.

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Review: capsule colonoscopy—a concise clinical overview of current status

Yung¹,

Rondonotti²,

Koulaouzidis³

2016

Ann. Transl. Med.

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Abstract:The colon capsule endoscopy (CCE) was first introduced in 2007. Currently, the main clinical indications for CCE are completion of incomplete colonoscopy, polyp detection and investigation of inflammatory bowel disease (IBD). Although conventional colonoscopy is the gold standard in bowel cancer screening, incomplete colonoscopy remains a problem as lesions are missed. CCE compares favourably to computer tomography colonography (CTC) in adenoma detection and has therefore been proposed as a method for completing colonoscopy. However the data on CCE remains sparse and current evidence does not show its superiority over CTC or conventional colonoscopy in bowel cancer screening. CCE also seems to show good correlation with conventional colonoscopy when used to evaluate IBD, but there are not many published studies at present. Other significant limitations include the need for aggressive bowel preparation and the labour-intensiveness of CCE reading. Therefore, much further software and hardware development is required to enable CCE to fulfill its potential as a minimally-invasive and reliable method of colonoscopy.

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Colorectal polyp diagnosis: results with the second‐generation colon capsule (CCE‐2)

Cited by 3 publications

References 28 publications

Initial US evaluation of second-generation capsule colonoscopy for detecting colon polyps

Initial US evaluation of second-generation capsule colonoscopy for detecting colon polyps

Intra and inter‐observer agreement on polyp detection in colon capsule endoscopy evaluations

Review: capsule colonoscopy—a concise clinical overview of current status

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