Colorectal tubulovillous adenomas identified on fluoro‐2‐deoxy‐<scp>d</scp>‐glucose positron emission tomography/computed tomography scans

Hemandas, Anil; Robson, Nicola; Hickish, Tamas; Talbot, R. W.

doi:10.1111/j.1463-1318.2007.01261.x

Cited by 11 publications

(8 citation statements)

References 14 publications

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“…[1], which assessed incidental colorectal tumours on positron emission tomography/computed tomography (PET/CT) scans with 2‐fluoro‐2‐deoxyglucose (FDG), is highly commendable. It supports the established principles and practice regarding lesions incidentally discovered on PET/CT scans of malignant [2] and premalignant [3] origin.…”

supporting

confidence: 74%

Predictive value according to location of incidental focal colorectal fluorodeoxyglucose uptake on positron emission tomography scans

2012

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supporting

confidence: 74%

Predictive value according to location of incidental focal colorectal fluorodeoxyglucose uptake on positron emission tomography scans

2012

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“…The sensitivity of PET/CT in visualising polyps ≤10 mm is only 21% (46 out of 219), and the 66% (163 out of 247) sensitivity in detecting masses >10 mm is disappointing compared with that of CT colonography (sensitivity 94%) [24, 27, 30, 47–49]. Despite the high molecular sensitivity of PET for the tracer (10 −11 –10 −12 mole/L), smaller polyps can be negative on PET if their signal is spatially and temporally averaged to normal in the 5 mm 3 image voxel and 3-min acquisition time per bed position (partial volume artefact).…”

Section: Discussionmentioning

confidence: 99%

Detection of relevant colonic neoplasms with PET/CT: promising accuracy with minimal CT dose and a standardised PET cut-off

et al. 2010

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Objective:To determine the performance of FDG-PET/CT in the detection of relevant colorectal neoplasms (adenomas ≥10 mm, with high-grade dysplasia, cancer) in relation to CT dose and contrast administration and to find a PET cut-off.Methods:84 patients, who underwent PET/CT and colonoscopy (n = 79)/sigmoidoscopy (n = 5) for colonic segments, were included in a retrospective study. The accuracy of low-dose PET/CT in detecting mass-positive segments was evaluated by ROC analysis by two blinded independent reviewers relative to contrast-enhanced PET/CT. On a per-lesion basis characteristic PET values were tested as cut-offs.Results:Low-dose PET/CT and contrast-enhanced PET/CT provide similar accuracies (area under the curve for the average ROC ratings 0.925 vs. 0.929, respectively). PET demonstrated all carcinomas (n = 23) and 83% (30/36) of relevant adenomas. In all carcinomas and adenomas with high-grade dysplasia (n = 10) the SUVmax was ≥5. This cut-off resulted in a better per-segment sensitivity and negative predictive value (NPV) than the average PET/CT reviews (sensitivity: 89% vs. 82%; NPV: 99% vs. 98%). All other tested cut-offs were inferior to the SUVmax.Conclusion:FDG-PET/CT provides promising accuracy for colorectal mass detection. Low dose and lack of iodine contrast in the CT component do not impact the accuracy. The PET cut-off SUVmax ≥ 5 improves the accuracy.

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“…In several studies, 18 F-FDG PET scans were retrospectively reviewed for abnormal colonic foci. If scan results were positive, a dysplastic adenoma was found in 32%-70% of patients by subsequent diagnostic colonoscopy, indicating that abnormal colonic hot spots at the 18 F-FDG PET scan frequently reflect adenomas (10,15,16). In rats, only 2 small studies have been performed assessing the role of 18 F-FDG PET in adenoma detection.…”

Section: Discussionmentioning

confidence: 99%

“…18 F-FDG is actively taken up and accumulates in tumor cells (7). In humans, colorectal adenomas are detected by 18 F-FDG PET to a variable extent depending on adenoma characteristics (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). 18 F-FDG PET in a mouse model of intestinal adenomas has not been reported.…”

mentioning

confidence: 99%

Total Abdominal ¹⁸F-FDG Uptake Reflects Intestinal Adenoma Burden in Apc Mutant Mice

et al. 2011

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Apc mutant (Apc Min ) mice develop multiple adenomas in their intestines and are widely used to study colorectal carcinogenesis and chemopreventive approaches. Molecular imaging of intestinal adenomas could potentially provide noninvasive longitudinal evaluation of these lesions in living mice. Therefore, the aim of this study was to investigate the role of 18 F-FDG PET in the Apc Min mouse model. Methods: Apc Min mice (n 5 8) fed a purified diet were imaged serially after injection of 18 F-FDG at age 9 and 12 wk using a small-animal PET scanner. Abdominal uptake of the tracer was quantified. After dissection, intestines were imaged separately, and intestinal tracer uptake was quantified. Tracer distribution was compared with results from microscopic examination regarding adenoma number and size. Thereafter, findings were validated serially in 20 Apc Min mice aged 6, 8, 10, and 12 wk that received standard chow to increase adenoma numbers. In vivo abdominal 18 F-FDG uptake was correlated with microscopy results. Results: Microscopic examination showed that the mice developed 25-35 intestinal adenomas at age 12 wk. Ex vivo 18 F-FDG PET of the dissected intestines visualized all large adenomas and most small adenomas. Ex vivo total intestinal 18 F-FDG uptake correlated with in vivo total abdominal uptake and with the number of large adenomas at age 9 and 12 wk. At 12 wk, there was a clear correlation between in vivo abdominal tracer uptake and the number of large adenomas but not the total number of lesions. Conclusion: Intestinal adenomas in Apc Min mice are metabolically active lesions that take up 18 F-FDG. Abdominal 18 F-FDG uptake at age 12 wk serves as a readout modality for large intestinal adenomas.

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Colorectal tubulovillous adenomas identified on fluoro‐2‐deoxy‐d‐glucose positron emission tomography/computed tomography scans

Abstract: Benign colonic polyps produce high-intensity focal FDG uptake in large bowel. Endoscopic evaluation is recommended before curative resectional surgery of the presenting cancer where appropriate.

Cited by 11 publications

References 14 publications

Predictive value according to location of incidental focal colorectal fluorodeoxyglucose uptake on positron emission tomography scans

Predictive value according to location of incidental focal colorectal fluorodeoxyglucose uptake on positron emission tomography scans

Detection of relevant colonic neoplasms with PET/CT: promising accuracy with minimal CT dose and a standardised PET cut-off

Total Abdominal ¹⁸F-FDG Uptake Reflects Intestinal Adenoma Burden in Apc Mutant Mice

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Colorectal tubulovillous adenomas identified on fluoro‐2‐deoxy‐d‐glucose positron emission tomography/computed tomography scans

Abstract: Benign colonic polyps produce high-intensity focal FDG uptake in large bowel. Endoscopic evaluation is recommended before curative resectional surgery of the presenting cancer where appropriate.

Cited by 11 publications

References 14 publications

Predictive value according to location of incidental focal colorectal fluorodeoxyglucose uptake on positron emission tomography scans

Predictive value according to location of incidental focal colorectal fluorodeoxyglucose uptake on positron emission tomography scans

Detection of relevant colonic neoplasms with PET/CT: promising accuracy with minimal CT dose and a standardised PET cut-off

Total Abdominal 18F-FDG Uptake Reflects Intestinal Adenoma Burden in Apc Mutant Mice

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Total Abdominal ¹⁸F-FDG Uptake Reflects Intestinal Adenoma Burden in Apc Mutant Mice