Colorimetric and Fluorescent Detecting Phosgene by a Second-Generation Chemosensor

Hu, Ying; Zhou, Xin; Jung, Hyeseung; Nam, Sang Jip; Kim, Myung Hwa; Yoon, Juyoung

doi:10.1021/acs.analchem.7b05011

Cited by 70 publications

(37 citation statements)

References 54 publications

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“…A number of novel reagents providing colored reaction products that exhibit visible, often predominating fluorescence were developed during the past decade. Examples include chemosensors based on pyronine, rhodamine, iminocoumarin, BODIPY, and other organic compounds [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. Their research is only at the laboratory stage, commercial evaluation is pending.…”

Section: Introductionmentioning

confidence: 99%

Second-Generation Phosgene and Diphosgene Detection Tube

et al. 2020

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We have developed a second-generation detection tube for colorimetric and fluorescence detection of phosgene and diphosgene in air. The tube is packed with pellets made of a mixture of microcrystalline cellulose and magnesium aluminum metasilicate treated with a suitable monoterpene (camphor, menthol) to increase porosity and specific surface area. We impregnated the pellets with a specific o-phenylenediamine-pyronin (PY-OPD) based reagent. The detector with this novel indication charge enables phosgene or diphosgene to be selectively and sensitively detected at concentrations lower than as would those posing acute health risk. Owing to the analytical colorimetric and, at the same time, fluorescence signal, the detector is very robust while featuring good sensitivity and variability. The colorimetric limits of detection were 0.3 mg/m3 (tristimulus colorimeter), resp. 5 mg/m3 (with the naked eye), fluorescence detection limits of 0.3 mg/m3 (with the naked eye), all at an air sample volume of 1 dm3. The response was practically immediate, acid vapors and gases, or diethyl chlorophosphate as a simulant of nerve warfare chemical agents, were disruptive.

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Section: Introductionmentioning

confidence: 99%

Second-Generation Phosgene and Diphosgene Detection Tube

et al. 2020

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“…The new rhodamine derivative 59 shows a distinct color change to dark pink and a 3.7-fold fluorescence enhancement at 578 nm when treated with phosgene. 90 The detection limit was calculated to be 3.2 ppb. Most importantly, unlike previously developed chemosensors, 55–58 , 59 reaction with phosgene does not produce HCl as a byproduct.…”

Section: Fluorescent Chemosensors For Various Analytesmentioning

confidence: 99%

Fluorescent Chemosensors for Various Analytes Including Reactive Oxygen Species, Biothiol, Metal Ions, and Toxic Gases

2018

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The development of fluorescent chemosensors for various analytes has been actively pursued by chemists. Since their inception, these efforts have led to many new sensors that have found wide applications in the fields of chemistry, biology, environmental science, and physiology. The search for fluorescent chemosensors was initiated by a few pioneering groups in the late 1970s and 1980s and blossomed during the last two decades to include more than hundreds of research groups around the world. The targets for these sensors vary from metal ions, anions, reactive oxygen/nitrogen species, biothiols, and toxic gases. Our group has made contributions to this area in last 18 years. In this perspective, we briefly introduce the history of chemosensors and review studies that we have carried out.

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“…Due to their low cost, specificity, high sensitivity, and ease of use, many fluorescent probes for phosgene have been reported [5] with two nucleophilic groups as the active site for the reaction, o ‐diamine (including one amine plus one o ‐aromatic nitrogen), [6a–y] one amine plus one o ‐hydroxy group, [7a–c] o ‐dihydroxy [8] group and others, [9a–l] and summarized in Table S1 in the Supporting Information. Among the largest class of probes, with o ‐phenylenediamine as the active site, would produce a similar fluorescence response to nitric oxide (NO), [6e, f] which induces o ‐phenylenediamine to form benzotriazole [10] …”

Section: Introductionmentioning

confidence: 99%

Sensitive and Visual Detection of Phosgene by a TICT‐Based BODIPY Dye with 8‐(o‐Hydroxy)aniline as the Active Site

Chong

et al. 2021

Chemistry A European J

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Phosgene and its substitutes (diphosgene and triphosgene) are widely utilized as chemical industrial materials and chemical warfare agents and pose a threat to public health and environmental safety due to their extreme toxicity. Research efforts have been directed to develop selective and sensitive detection methods for phosgene and its substitutes. In this paper, we have prepared two BODIPY‐based fluorescent probes, o‐Pah and o‐Pha, which are two isomers with different active sites, ortho‐aminohydroxy (3′,4′ or 4′,3′) phenyls at meso position of BODIPY, and compared their sensing performance toward triphosgene. The probe with o‐(4′‐amino‐3′‐hydroxyl), o‐Pha, exhibits better sensing performance over the o‐(3′‐amino‐4′‐hydroxyl), o‐Pah, for instance, a lower limit of detection (LOD) (0.34 nm vs. 1.2 nm), and more rapid response (10 s vs. 200 s). Furthermore, based on the above comparative studies, a red‐fluorescence probe o‐Phae has been constructed through extending 3,5‐conjugation of o‐Pha. The probe o‐Phae displays rapid response (60 s), high sensitivity to triphosgene (LOD=0.88 nm), and high selectivity for triphosgene over relevant analytes including nitric oxide. Finally, a facile test strip for phosgene was fabricated by immobilizing o‐Phae in a polyethylene oxide membrane for sensitive (<2 ppm) and selective detection of phosgene in the gas phase.

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Colorimetric and Fluorescent Detecting Phosgene by a Second-Generation Chemosensor

Cited by 70 publications

References 54 publications

Second-Generation Phosgene and Diphosgene Detection Tube

Second-Generation Phosgene and Diphosgene Detection Tube

Fluorescent Chemosensors for Various Analytes Including Reactive Oxygen Species, Biothiol, Metal Ions, and Toxic Gases

Sensitive and Visual Detection of Phosgene by a TICT‐Based BODIPY Dye with 8‐(o‐Hydroxy)aniline as the Active Site

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