Colorimetric evaluation after in-office tooth bleaching with violet LED: 6- and 12-month follow-ups of a randomized clinical trial

Kury, Matheus; Wada, Erica Eiko; Palandi, Samuel da Silva; Picolo, Mayara Zaghi Dal; Giannini, Marcelo; Cavalli, Vanessa

doi:10.1007/s00784-021-04062-9

Cited by 28 publications

(18 citation statements)

References 42 publications

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“…Thus, the nal color assessment had to be done 2 to 6 months after bleaching for some patients. Still, it is unlikely to have introduced bias because the comparison of the immediate results (approximately 30 days after bleaching) and those obtained 3 to 12 months after bleaching did not report any statistical and clinical differences between these assessment periods [46][47][48][49][50].…”

Section: Discussionmentioning

confidence: 99%

Effect of an experimental desensitizing gel on bleaching-induced tooth sensitivity after in-office bleaching - a double-blind, randomized controlled trial

Vochikovski

Favoreto

Rezende³

et al. 2022

Preprint

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Objectives: To evaluate the risk and intensity of tooth sensitivity (TS), and the efficacy of in-office bleaching after applying an experimental desensitizing gel composed of 10% calcium gluconate, 0.1% dexamethasone acetate, 10% potassium nitrate, and 5% glutaraldehyde.Material and Methods: In a split-mouth, double-blind, placebo-controlled study, 50 participants had their upper hemiarches randomized into experimental and placebo groups. Desensitizing and placebo gels were applied for 10 min before in-office bleaching (35% hydrogen peroxide, 1x50 min; two bleaching sessions; one-week interval). TS was recorded immediately after bleaching, 1, 24, and 48 h after each session, with a 0-10 visual analogue scale (VAS) and a five-point numerical rating scale (NRS). The color was recorded at baseline, one week after each session, and one month after the end of bleaching using shade guide units (ΔSGUs) and a spectrophotometer (ΔEab, ΔE00, and ΔWID). Results: Most participants (96%) felt some discomfort during treatment regardless of the study group. The odds ratio for pain was 0.65 (95% CI 0.1 to 4.1; p = 1.0). The intensity of TS did not differ between groups (p > 0.31), and it was only 0.34 VAS units lower in the experimental group. A significant color change occurred in all groups regardless of the group.Conclusions: The desensitizing experimental gel applied before in-office bleaching did not reduce the risk and the intensity of TS and did not affect color change.Clinical Relevance: Although the experimental desensitizing agent with varying mechanisms of action did not jeopardize the color change, it did not reduce the risk or intensity of in-office bleaching. Clinical Trial Registration Number: RBR-7T7D4D

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Section: Discussionmentioning

confidence: 99%

Effect of an experimental desensitizing gel on bleaching-induced tooth sensitivity after in-office bleaching - a double-blind, randomized controlled trial

Vochikovski

Favoreto

Rezende³

et al. 2022

Preprint

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“…Since the vast majority of clinical bleaching procedures still employs HP independently of the application regimen, [40][41][42][43] the evaluation of the real necessity for the gel's renewal might add valuable information in terms of protocols' efficacy, safety, and cost-effectiveness. The present data suggests that the renewal of bleaching gels during the in-office bleaching session would not be necessary, thereby representing a decrease in the total time of the appointment itself and in the materials' costs, followed by the maintenance of the level of esthetic outcomes.…”

Section: Discussionmentioning

confidence: 99%

The influence of the renewal or the single application of the peroxide gel on the efficacy and tooth sensitivity outcomes of in‐office bleaching—A systematic review and meta‐analysis

Kury

Lins

Resende

et al. 2021

J Esthet Restor Dent

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Objective To answer the question: “Does the peroxide gel application regimen (single application vs. renewal) influence the efficacy and the tooth sensitivity outcomes of in‐office tooth bleaching?” Methods The search was done in Pubmed, Cochrane, LILACS, Scopus, Web of Science, and EMBASE in February 2021 (updated in July 2021). Randomized clinical trials (RCT) comparing the single application vs. the renewal protocols of HP were included. The meta‐analyses were performed for the objective (ΔEab), subjective (ΔSGU) color changes, and absolute risk of tooth sensitivity (TS). Heterogeneity was evaluated using Q test (I2). Cochrane Collaboration tool assessed the risk of bias (RoB). The GRADE evaluated the certainty of evidence. Results Five RCT studies remained. Two studies showed high RoB, and three presented some concerns. No significant differences were observed between the protocols in terms of the ΔEab, ΔSGU, and TS. ΔEab exhibited substantial heterogeneity (I2 = 87%), while ΔSGU (I2 = 60%) and the TS (I2 = 62%) presented a moderate one. The certainty of evidence was considered low or very low, depending on the variable response and the evaluation time. Conclusion The application regimen (single vs. renewal of HP) did not impact color change or the absolute risk of TS. Clinical significance The renewal of bleaching gel during the in‐office appointment may not be necessary. However, there is at least a low certainty of evidence. Because of this, further randomized clinical trials with appropriate methodology on this topic are encouraged.

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“…Immediately before utilization, experimental gels (either 1 g or 1.5 g, depending on the H 2 O 2 :polymer ratio) with or without NP (either 5% or 10%) were manually mixed (1:2 (6% or 15% H 2 O 2 ) or 2:3 (35% H 2 O 2 )) with 1 mL of hydrogen peroxide following previously published protocols ( Figure 1 ) [ 10 , 19 ]. The rationale for the utilization of two distinct H 2 O 2 :polymer ratios was based on the need to achieve comparable viscosities for all experimental materials investigated.…”

Section: Methodsmentioning

confidence: 99%

“…The experimental bleaching protocols investigated consisted of 3 sessions (T 1 = first bleaching session, T 2 = second bleaching session, and T 3 = third bleaching session) 7 days apart. Each 30 min session was based on a single application of the proper experimental gel (with or without nanoparticles), combined or not, with continuously visible light irradiation (20 cycles of 1 min, 30 s intervals between irradiation cycles [ 19 ]; 405 ± 15 nm, 1.2 W/cm 2 , emission window area = 10.7 cm 2 , Bright Max Whitening, MMO, São Carlos, SP, Brazil) according to experimental groups (G1 to G20; see group descriptions in Section 2.2 . Specimen Preparation and Experimental groups ).…”

Section: Methodsmentioning

confidence: 99%

“…Even though the reported results have demonstrated that adverse effects such as decreased enamel microhardness and rougher surfaces were less pronounced with the utilization of calcium- or fluorine-containing gels [ 8 ], subsequent studies have shown that the promising results initially reported were limited to the outermost layers of enamel and did not prevent the loss of minerals at subsurface levels, thereby restricting the therapeutic effect of the novel formulations proposed [ 9 ]. Follow-up studies investigated the efficacy of experimental protocols modulated by low-concentrated bleaching gels (6–15%) and near-UVA wavelengths (405 ± 15 nm) as an alternative approach to reducing the incidence of dentin hypersensitivity while trying to achieve desirable whitening outcomes [ 19 , 20 , 21 ]. Even though the utilization of low-concentrated bleaching gels resulted in lower incidences of DH, the bleaching efficacies reported (in terms of ΔE and whitening index (WI)) were considered poor because the outcomes were much less intense and durable as compared to those attained with gels containing high HP concentrations.…”

Section: Introductionmentioning

confidence: 99%

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Novel Experimental In-Office Bleaching Gels Containing Co-Doped Titanium Dioxide Nanoparticles

et al. 2022

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The present study reports on the development and testing of novel bleaching agents containing co-doped metaloxide nanoparticles (NP; 0%, 5%, 10% v/w) and hydrogen peroxide (HP, 0%, 6%, 15%, and 35%). Bovine blocks (n = 200, A = 36 mm2) were obtained and randomly distributed into experimental groups (n = 10/group). NPs were incorporated into gels before bleaching (3 sessions, 7 days apart, 30 min/session, irradiated with violet light-LT). Color changes (ΔE00, ΔWID), mineral content (CO32−, PO43−), and topography were assessed (spectrophotometer, ATR-FTIR, and AFM) before and after bleaching procedures (14 days). Metabolic status and three-dimensional components of non-disrupted Streptococcus mutans biofilms were investigated using a multimode reader and confocal microscopy. The results indicate that ΔE00 and ΔWID significantly increased with NPs’ concentrations and LT. The enamel’s mineral ratio was adversely impacted by HP, but alterations were less pronounced when using NP-containing gels. The enamel’s topography was not damaged by the bleaching protocols tested. The bioluminescence results show that bleaching protocols do not render latent antibacterial properties to enamel, and the confocal microscopy results demonstrate that the 3-dimensional distribution of the components was affected by the protocols. The proposed nanotechnology improved the bleaching efficacy of experimental materials independent of hydrogen peroxide or irradiation and did not adversely impact the enamel’s surface properties or its chemical content.

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Colorimetric evaluation after in-office tooth bleaching with violet LED: 6- and 12-month follow-ups of a randomized clinical trial

Cited by 28 publications

References 42 publications

Effect of an experimental desensitizing gel on bleaching-induced tooth sensitivity after in-office bleaching - a double-blind, randomized controlled trial

Effect of an experimental desensitizing gel on bleaching-induced tooth sensitivity after in-office bleaching - a double-blind, randomized controlled trial

The influence of the renewal or the single application of the peroxide gel on the efficacy and tooth sensitivity outcomes of in‐office bleaching—A systematic review and meta‐analysis

Novel Experimental In-Office Bleaching Gels Containing Co-Doped Titanium Dioxide Nanoparticles

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