Colorless Multifunctional Coatings Inspired by Polyphenols Found in Tea, Chocolate, and Wine

Sileika, Tadas S.; Barrett, Devin G.; Zhang, Ran; Lau, King Hang Aaron; Messersmith, Phillip B.

doi:10.1002/anie.201304922

Cited by 777 publications

(794 citation statements)

References 25 publications

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“…Polyphenols (PPs), which are commonly distributed in plant tissues to serve diverse biological roles, represent a wide range of physicochemical natures and thereby give rise to broad chemical versatility in industrial, pharmacological, biomedical, and food additive applications. 16,17 The dominant constituents for virtually all PPs are catechol and galloyl, which are known to possess strong metal chelation ability and materials surface binding affinity. 18,19 Recently, researchers found that catechol units and catechol ferric ion complexes in adhesive proteins greatly account for the excellent adhesive ability of marine mussels.…”

mentioning

confidence: 99%

Enhanced catalytic application of Au@polyphenol-metal nanocomposites synthesized by a facile and green method

et al. 2014

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Development of novel nanostructure gold-based catalysts with high performance and low cost is of a great scientific interest. Here, a new controllable coordination coating was facilely integrated onto gold nanoparticles (Au NPs) using low-cost natural polyphenols and ferric ions. Heat treatment, organic solvents, special instruments, or additive chemicals were not involved in the whole synthetic procedure. Due to the presence of the unique polyphenol-Fe 3+ shell, the as-prepared catalyst showed an improved catalytic performance, pH-responsive character and good stability towards the reduction of 4-NP.Noble metal NPs have received enormous interest in a wide variety of applications, especially in heterogeneous catalysis owing to their large specic surface areas and increased number of exposed metal atoms, which greatly change their catalytic and physicochemical properties. 1,2 Among them, Au NPs have been proved to exhibit extraordinary performance in a number of oxidation and reduction reactions.3-5 However, Au NPs in catalytic reactions oen show a strong tendency to aggregate because of their high surface energies, leading to the loss of their initial activities.6 Hence, core-shell architectures with a noble metal core preserved by an outer shell have recently attracted a great deal of attention for catalysis due to the following structural advantages: (a) the shell can hinder the aggregation of neighboring cores 7,8 and (b) remarkable catalytic activity may be achieved due to the unique identity of the shell or the interaction of the shell and the core.9,10 Over the years, a series of intriguing materials have been put into the design of such core-shell nanocatalyst systems with some specic merits.11,12 To name a few, wrapping Au NPs within mesoporous silica shells to endow them with high activity and outstanding stability even under harsh conditions; 13 coating metal-organic frameworks onto the surface of Au NPs to enhance the catalytic activity through a synergistic effect;14 encapsulating Au NPs within stimuli-responsive polymers to tune the mass transport of reactants and thus modulate the catalytic process.15 However, the above-mentioned synthetic procedures oen suffer from sophisticated and time-consuming steps and requirement of various toxic reagents, which may be impediments for some practical applications. Accordingly, a concise, facile and environmentally friendly approach should be developed to obtain a novel core-shell Au catalytic system with distinct performance. Polyphenols (PPs), which are commonly distributed in plant tissues to serve diverse biological roles, represent a wide range of physicochemical natures and thereby give rise to broad chemical versatility in industrial, pharmacological, biomedical, and food additive applications. 16,17 The dominant constituents for virtually all PPs are catechol and galloyl, which are known to possess strong metal chelation ability and materials surface binding affinity. 18,19 Recently, researchers found that catechol units and catechol ferric ion co...

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confidence: 99%

Enhanced catalytic application of Au@polyphenol-metal nanocomposites synthesized by a facile and green method

et al. 2014

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“…[35][36][37] The formation and cleavage of coordination bonds between TA and metal ions are pH dependent. 38 Herein, we engineered a kind of drug delivery system based on metal-TA films on zein/CMCS NPs, and the coated NPs exhibited controllable pH-dependent intracellular drug release (Scheme 1).…”

Section: Resultsmentioning

confidence: 99%

“…The metal-ligand films had controllable pH-dependent degradability, which led to an association of DOX release profile with the film degradation kinetics. [35][36][37]49 When the amount of Cu 2+ was increased, the onset of responsive pH dramatically reduced due to the high stability of the , which resulted in the fast release of DOX.…”

Section: In Vitro Drug Releasementioning

confidence: 99%

Tailoring stimuli-responsive delivery system driven by metal–ligand coordination bonding

Liang¹,

Zhou²,

He³

et al. 2017

IJN

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In this study, a novel coordination bonding system based on metal–tannic acid (TA) architecture on zein/carboxymethyl chitosan (CMCS) nanoparticles (NPs) was investigated for the pH-responsive drug delivery. CMCS has been reported to coat on zein NPs as delivery vehicles for drugs or nutrients in previous studies. The cleavage of either the “metal–TA” or “NH 2 –metal” coordination bonds resulted in significant release of guest molecules with high stimulus sensitivity, especially in mild acidic conditions. The prepared metal–TA-coated zein/CMCS NPs (zein/CMCS-TA/metal NPs) could maintain particle size in cell culture medium at 37°C, demonstrating good stability compared with zein/CMCS NPs. In vitro release behavior of doxorubicin hydrochloride (DOX)-loaded metal–TA film-coated zein/CMCS NPs (DOX-zein/CMCS-TA/metal NPs) showed fine pH responsiveness tailored by the ratio of zein to CMCS as well as the metal species and feeding concentrations. The blank zein/CMCS-TA/metal NPs (NPs-TA/metal) were of low cytotoxicity, while a high cytotoxic activity of DOX-zein/CMCS-TA/metal NPs (DOX-NPs-TA/metal) against HepG2 cells was demonstrated by in vitro cell assay. Confocal laser scanning microscopy (CLSM) and flow cytometry were combined to study the uptake efficiency of DOX-NPs or DOX-NPs-TA/metal. This system showed significant potential as a highly versatile and potent platform for drug delivery.

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“…Messersmith is looking beyond DOPA to sticky chemicals known as polyphenols, found in cacao, green tea and red wine 3 . Such compounds have similar chemical properties to DOPA and can be more cheaply extracted, he says.…”

Section: Climbers and Creepersmentioning

confidence: 99%

Synthetic coatings: Super surfaces

Savage¹

2015

Nature

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Colorless Multifunctional Coatings Inspired by Polyphenols Found in Tea, Chocolate, and Wine

Cited by 777 publications

References 25 publications

Enhanced catalytic application of Au@polyphenol-metal nanocomposites synthesized by a facile and green method

Enhanced catalytic application of Au@polyphenol-metal nanocomposites synthesized by a facile and green method

Tailoring stimuli-responsive delivery system driven by metal–ligand coordination bonding

Synthetic coatings: Super surfaces

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Colorless Multifunctional Coatings Inspired by Polyphenols Found in Tea, Chocolate, and Wine

Cited by 777 publications

References 25 publications

Enhanced catalytic application of Au@polyphenol-metal nanocomposites synthesized by a facile and green method

Enhanced catalytic application of Au@polyphenol-metal nanocomposites synthesized by a facile and green method

Tailoring stimuli-responsive delivery system driven by metal&ndash;ligand coordination bonding

Synthetic coatings: Super surfaces

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Tailoring stimuli-responsive delivery system driven by metal–ligand coordination bonding