Colostrogenesis: Role and Mechanism of the Bovine Fc Receptor of the Neonate (FcRn)

Baumrucker, Craig R.; Macrina, A.L.; Bruckmaier, Rupert M.

doi:10.1007/s10911-021-09506-2

Cited by 18 publications

(11 citation statements)

References 346 publications

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“…B2M, initially isolated from bovine milk as the minor whey protein lactollin ( Groves et al. 1963 ; Groves and Greenberg 1977 ), is the light chain component of the neonatal Fc receptor (FcRn) heterodimer that binds, transports, and protects IgG and serum albumin from degradation ( Baumrucker et al. 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Key changes in bovine milk immunoglobulin G during lactation: NeuAc sialylation is a hallmark of colostrum immunoglobulin GN-glycosylation

et al. 2023

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We monitored longitudinal changes in bovine milk IgG in samples from four cows at 9 time points in between 0.5–28 days following calving. We used peptide-centric LC–MS/MS on proteolytic digests of whole bovine milk, resulting in the combined identification of 212 individual bovine milk protein sequences, with IgG making up >50 percent of the protein content of every 0.5 d colostrum sample, which reduced to ≤3 percent in mature milk. In parallel, we analysed IgG captured from the bovine milk samples to characterise its N-glycosylation, using dedicated methods for bottom-up glycoproteomics employing product ion-triggered hybrid fragmentation; data are available via ProteomeXchange with identifier PXD037755. The bovine milk IgG N-glycosylation profile was revealed to be very heterogeneous, consisting of >40 glycoforms. Furthermore, these N-glycosylation profiles changed substantially over the period of lactation, but consistently across the four individual cows. We identified NeuAc sialylation as the key abundant characteristic of bovine colostrum IgG, significantly decreasing in the first days of lactation, and barely detectable in mature bovine milk IgG. We also report, for the first time to our knowledge, the identification of subtype IgG3 in bovine milk, alongside the better-documented IgG1 and IgG2. The detailed molecular characteristics we describe of the bovine milk IgG, and their dynamic changes during lactation, are important not only for the fundamental understanding of the calf’s immune development, but also for understanding bovine milk and its bioactive components in the context of human nutrition.

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Section: Discussionmentioning

confidence: 99%

Key changes in bovine milk immunoglobulin G during lactation: NeuAc sialylation is a hallmark of colostrum immunoglobulin GN-glycosylation

et al. 2023

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“…IgG1 and IgG2 are the most abundant subclass in ungulate blood serum, but only IgG1 is selectively transported to colostrum because of its unique structure. All these differences are related to placental and mammary immunoglobulin transport mechanisms ( Butler and Kehrli, 2005 ; Baumrucker et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“… Data from Baumrucker et al, 2021 ; * unpublished data (Baumrucker & Macrina, 2023). a Blood concentration at week before birth …”

Section: Introductionmentioning

confidence: 99%

“…However, it is not concentrated in colostrum. In addition, we have added lactoferrin to Table 1 because it has a strong positive relationship with IgG1 concentration and mass in the first-milked colostrum ( Baumrucker et al, 2021 ). Lactoferrin is synthesized in mammary cells and secreted into colostrum and therefore a milk/blood ratio is not listed ( Table 1 ).…”

Section: Introductionmentioning

confidence: 99%

“…During the colostrogenesis phase of mammary development, there is a selective transfer, termed transcytosis, but only IgG1 is transfered to the forming colostrum while IgG2 and BSA are recycled. Recently, Baumrucker et al (2021) provided a hypothesis that the FcRn transcytosis of IgG1 and recycling of IgG2 occurs with very slight, but significant differences in the amino acid structure of the two immunoglobulins.…”

Section: Introductionmentioning

confidence: 99%

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Short communication: The biological value of transition milk: analyses of immunoglobulin G, IGF-I and lactoferrin in primiparous and multiparous dairy cows

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Colostrogenesis: Role and Mechanism of the Bovine Fc Receptor of the Neonate (FcRn)

Cited by 18 publications

References 346 publications

Key changes in bovine milk immunoglobulin G during lactation: NeuAc sialylation is a hallmark of colostrum immunoglobulin GN-glycosylation

Key changes in bovine milk immunoglobulin G during lactation: NeuAc sialylation is a hallmark of colostrum immunoglobulin GN-glycosylation

The importance of colostrum in maternal care and its formation in mammalian species

Short communication: The biological value of transition milk: analyses of immunoglobulin G, IGF-I and lactoferrin in primiparous and multiparous dairy cows

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