Colostrum and severe gut GVHD

Inoue, Masami; Okamura, Takayuki; Sawada, Akihisa; Kawa, Keisei

doi:10.1038/sj.bmt.1701369

Cited by 8 publications

(5 citation statements)

References 1 publication

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“…Bioactive factors in milk have previously been reported to ameliorate mucosal toxicity after administering chemotherapeutic agents to rats and hamsters, and there is also some evidence for beneficial effects in human chemotherapy patients (11,14,15,22,23,44,59). Such effects include reducing bacterial translocation across the gut mucosa in patients after abdominal surgery (9) and reducing intestinal permeability caused by nonsteroidal anti-inflammatory drugs that facilitate bacterial translocation to the mesenteric lymph nodes, liver, spleen, and peripheral blood (29,30).…”

Section: Discussionmentioning

confidence: 99%

Milk diets influence doxorubicin-induced intestinal toxicity in piglets

Shen

Pontoppidan

Rathe

et al. 2016

American Journal of Physiology-Gastrointestinal and Liver Physi

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Chemotherapy-induced gastrointestinal (GI) toxicity is a common adverse effect of cancer treatment. We used preweaned piglets as models to test our hypothesis that the immunomodulatory and GI trophic effects of bovine colostrum would reduce the severity of GI complications associated with doxorubicin (DOX) treatment. Five-day-old pigs were administered DOX (1 × 100 mg/m(2)) or an equivalent volume of saline (SAL) and either fed formula (DOX-Form, n = 9, or SAL-Form, n = 7) or bovine colostrum (DOX-Colos, n = 9, or SAL-Colos, n = 7). Pigs were euthanized 5 days after initiation of chemotherapy to assess markers of small intestinal function and inflammation. All DOX-treated animals developed diarrhea, growth deficits, and leukopenia. However, the intestines of DOX-Colos pigs had lower intestinal permeability, longer intestinal villi with higher activities of brush border enzymes, and lower tissue IL-8 levels compared with DOX-Form (all P < 0.05). DOX-Form pigs, but not DOX-Colos pigs, had significantly higher plasma C-reactive protein, compared with SAL-Form. Plasma citrulline was not affected by DOX treatment or diet. Thus a single dose of DOX induces intestinal toxicity in preweaned pigs and may lead to a systemic inflammatory response. The toxicity is affected by type of enteral nutrition with more pronounced GI toxicity when formula is fed compared with bovine colostrum. The results indicate that bovine colostrum may be a beneficial supplementary diet for children subjected to chemotherapy and subsequent intestinal toxicity.

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Section: Discussionmentioning

confidence: 99%

Milk diets influence doxorubicin-induced intestinal toxicity in piglets

Shen

Pontoppidan

Rathe

et al. 2016

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…A small case series describes the use of colostrums obtained from humans in children undergoing bone marrow transplantation (Inoue et al 1998 ) ; however the safety of its use is unclear in children with cancer. Colostrum has been administered to infants for the management of diarrhea (Sarker et al 1998 ;Szajewska and Mrukowicz 2001 ;Tawfeek et al 2003 ) .…”

Section: Diarrheamentioning

confidence: 99%

“…Colostrum is the milk secreted by mammals within the fi rst few days after giving birth and contains high concentrations of antibodies (IgG, IgM, and IgA), cytokines (interleukin-1 beta, interleukin-6, tumor necrosis factor-alpha, and interferon-gamma), growth factors (insulin-like growth factor I and II, transforming growth factor-beta, epidermal growth factor), lactoperoxidase, and lactoferrin (Inoue et al 1998 ) . A small case series describes the use of colostrums obtained from humans in children undergoing bone marrow transplantation (Inoue et al 1998 ) ; however the safety of its use is unclear in children with cancer.…”

Section: Diarrheamentioning

confidence: 99%

Integrative Nutrition and Nutrition/Herbal Supplements

Ladas

2012

Integrative Pediatric Oncology

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“…In an application for approval from the Ministry of Health, Labour and Welfare, the preliminary results of an additional prospective study for MSC have also been presented [134]. Pilot studies have been performed to assess the feasibility of colostrum obtained from random donors [135], betamethasone enemas [136], infliximab [137], and narrowband ultraviolet B phototherapy [138].…”

Section: Second-line Therapy Of Acute Gvhdmentioning

confidence: 99%