Colostrum of Healthy Mothers Contains Broad Spectrum of Secretory IgA Autoantibodies

Přibylová, Jaroslava; Krausova, Klara; Kocourková, I; Rossmann, P; Klimešová, Klára; Kverka, Miloslav; Tlaskalová‐Hogenová, Helena

doi:10.1007/s10875-012-9733-9

Cited by 25 publications

(24 citation statements)

References 30 publications

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“…It is commonly classified into: colostrum, transitional milk and mature milk, with reference to a gradual adjustment process (Ballard and 6 Morrow, 2013). Colostrum is the secretion produced during the first few days after delivery, containing a wide array of proteins and growth factors, and it is rich in immunological components, such as immunoglobulins and leukocytes, which play a major role in building up the immune system in newborns (Gephart and Weller, 2014;Neville et al, 1988;Neville and Morton, 2018;Pang and Hartmann, 2007;Pribylova et al, 2012). Transitional milk is produced after colostrum and lasts for approximately two weeks.…”

Section: Lactation Stagesmentioning

confidence: 99%

Nutritional and immunological factors in breast milk: A role in the intergenerational transmission from maternal psychopathology to child development

Benedetto

Bottanelli

Cattaneo

et al. 2020

Brain, Behavior, and Immunity

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Perinatal psychopathologies affect more than 25% of women during and after their gestational period. These psychiatric disorders determine important biological variations in their organisms, affecting many different physiological and metabolic pathways. Of relevance, any of these changes occurring in the mother can alter the normal composition of breast milk, particularly the concentration of nutritional and inflammatory components, which play a role in child brain functioning and development. Indeed, there is evidence showing that changes in milk composition can contribute to cognitive impairments and alterations in mental abilities in children. This review aims to shed light on the unique intergenerational role played by breast milk composition, from maternal psychopathologies to child development.

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Section: Lactation Stagesmentioning

confidence: 99%

Nutritional and immunological factors in breast milk: A role in the intergenerational transmission from maternal psychopathology to child development

Benedetto

Bottanelli

Cattaneo

et al. 2020

Brain, Behavior, and Immunity

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“…5 Anti-a IIb b 3 antibody was also found in 1 control sample, which might be explained by the broad spectrum of IgA antibodies found in colostrum samples of healthy mothers, and was suggested to be important for the anti-idiotype network. 6 The primary mechanism for platelet destruction in ITP is thought to be autoantibody-dependent phagocytosis, especially in cases of antia IIb b 3 antibodies. 2,7 IgA, which interacts with FcaRI expressed on monocytes and macrophages, can initiate antibody-dependent cellmediated cytotoxicity.…”

Section: Representative Patientmentioning

confidence: 99%

Persistent neonatal thrombocytopenia can be caused by IgA antiplatelet antibodies in breast milk of immune thrombocytopenic mothers

Hauschner

Rosenberg

Seligsohn

et al. 2015

Blood

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Key Points• Persistent thrombocytopenia was observed in breastfed neonates of ITP women.• Breast milk of ITP women may contain immunoglobulin A antiplatelet antibodies, which target a IIb b 3 integrin.Immune thrombocytopenia (ITP) in pregnant women can cause neonatal thrombocytopenia by transport of antiplatelet autoantibodies across the placenta. Usually, an infant's platelet count normalizes within 2 months. We observed neonatal thrombocytopenia that persisted more than 4 months and disappeared following discontinuation of breastfeeding. The aim of our study was to discern whether breast milk of ITP mothers contained antiplatelet antibodies causing persistent thrombocytopenia. We collected milk samples from 3 groups of women: ITP group, 7 women who had ITP during pregnancy; R-ITP group, 6 women who recovered from ITP before pregnancy; and 9 healthy controls. We found increased levels of antiplatelet antibodies of the immunoglobulin A type in the milk of ITP patients compared with the other 2 groups. Similar increase was demonstrated for antibodies binding to a IIb b 3 expressed in cultured cells. Thus, transfer of antiplatelet antibodies from ITP mothers by breastfeeding can be associated with persistent neonatal thrombocytopenia. (Blood. 2015;126(5):661-664)

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“…The gradual maturation of the mucosa leads to improvement of its protective functions and gradual extinction of inflammation. The development of mucosal immune system might be modulated also by the presence of polyreactive natural IgA autoantibodies found in human colostrums [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

High Prevalence of Neutrophil Cytoplasmic Autoantibodies in Infants with Food Protein-Induced Proctitis/Proctocolitis: Autoimmunity Involvement?

Sekerkova

Fuchs²,

Cecrdlova

et al. 2015

Journal of Immunology Research

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Background. Food protein-induced proctitis/proctocolitis (FPIP) is the most common noninfectious colitis in children in the first year of life. Along with the overall clinical symptoms, diarrhoea and rectal bleeding are the main manifestations of the disease. There is no routine noninvasive test that would be specific for this type of colitis. The aim of our study was to find a noninvasive laboratory test or tests that may be helpful in differential diagnosis of food protein-induced proctitis/proctocolitis. Methods. ANA, ANCA, ASCA, a-EMA, a-tTg, specific IgE, total IgE, IgG, IgA, IgM, and concentration of serum calprotectin were measured in a group of 25 patients with colitis and 18 children with other diagnoses. Results. Atypical-pANCA antibodies of IgG isotype were detected in the sera of 24 patients by the method of indirect immunofluorescence, and 5 patients showed also the positivity of IgA isotype. In control samples these autoantibodies were not detected. Other autoantibodies were not demonstrated in either patient or control group. Conclusions. Of the parameters tested in noninfectious colitis, atypical-pANCA on ethanol-fixed granulocytes appears to be a suitable serological marker of food protein-induced proctitis/proctocolitis and suggests a possible involvement of an autoimmune mechanisms in the pathogenesis of this disease.

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Colostrum of Healthy Mothers Contains Broad Spectrum of Secretory IgA Autoantibodies

Cited by 25 publications

References 30 publications

Nutritional and immunological factors in breast milk: A role in the intergenerational transmission from maternal psychopathology to child development

Nutritional and immunological factors in breast milk: A role in the intergenerational transmission from maternal psychopathology to child development

Persistent neonatal thrombocytopenia can be caused by IgA antiplatelet antibodies in breast milk of immune thrombocytopenic mothers

High Prevalence of Neutrophil Cytoplasmic Autoantibodies in Infants with Food Protein-Induced Proctitis/Proctocolitis: Autoimmunity Involvement?

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