Colostrum source and passive immunity transfer in dairy bull calves

Hue, Do T.; Skirving, Rebel; Chen, Tong; Williams, J. L.; Bottema, Cynthia D.K.; Petrovski, Kiro

doi:10.3168/jds.2020-19318

Cited by 15 publications

(14 citation statements)

References 49 publications

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“…In this study, we provided evidence that the expression of FcRn in the gut of piglets peaked on postnatal d 1, and thereafter FcRn expression gradually decreased with the piglets age, consistent with previous studies ( Mayer et al, 2002 ). On the other hand, the IgG content of breast milk changed rapidly with the passage of postpartum time, decreasing by 30% within 3 h after delivery and by nearly 90% at 24 h after delivery ( Kielland et al, 2015 ; Hue et al, 2021 ). Therefore, targeted regulation of FcRn molecule during the IgG-rich period of breast milk may be an effective measure to improve IgG absorption efficiency in piglets.…”

Section: Discussionmentioning

confidence: 99%

Early flora colonization affects intestinal immunoglobulin G uptake in piglets, which may be mediated by NF-κB-FcRn pathway

Peng

Zhang²,

He³

et al. 2023

Front. Microbiol.

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IntroductionThe passive immunity of newborn piglets is mainly derived from immunoglobulin G (IgG) in breast milk, and the incomplete transfer of passive immune is considered to be an important cause of piglet death. This study was conducted to investigate the effect of early intestinal flora colonization on IgG uptake and its possible mechanism.MethodsThe newborn piglets and IPEC-J2 cells were used to investigate the possible factors and regulatory mechanisms affecting intestinal IgG uptake. In vivo, all 40 piglets were euthanized on postnatal d 0, 1, 3, and 7, with 10 piglets per time. The blood sample, gastric contents, jejunal contents and mucosa were collected for analysis. In vitro, IPEC-J2 cells transwell culture system was used to establish the IgG transporter model to explore the specific regulatory mechanism of IgG transport.ResultsOur results demonstrated that the intestinal IgG uptake was positively correlated with the expression of Neonatal Fc receptor (FcRn). With the increase of age, the intestinal flora of newborn piglets was gradually enriched. The function of intestinal genes also changes with the colonization of intestinal flora. We found that the expression trend of TLR2, TLR4 and NF-κB (P65) in intestine was consistent with that of FcRn. Furthermore, the in vitro results demonstrate that the NF-κB signaling pathway is involved in regulating FcRn-mediated IgG transmembrane transport.DiscussionEarly flora colonization affects intestinal IgG uptake in piglets, which may be mediated by NF-κB-FcRn pathway.

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Section: Discussionmentioning

confidence: 99%

Early flora colonization affects intestinal immunoglobulin G uptake in piglets, which may be mediated by NF-κB-FcRn pathway

Peng

Zhang²,

He³

et al. 2023

Front. Microbiol.

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“…To validate the accuracy of refractometry results, a portion of the frozen serum samples ( n = 132) were selected at random for bovine IgG ELISA testing, following procedures described by Hue et al (2021) [ 46 ]. The total soluble protein concentration was then compared to the ELISA IgG results, using the categories from the review by Lombard et al (2020) [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

Incidence of Inadequate Transfer of Passive Immunity in Dairy Heifer Calves in South Australia

Skirving

Bottema

Laven

et al. 2022

Animals

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The objective of this observational study was to estimate the incidence of inadequate transfer of passive immunity (ITPI) on five pasture-based dairy farms in South Australia. Heifer calf uptake of colostrum was evaluated within the first 1–7 days of age (n = 2638) using a digital refractometer to estimate each calf’s serum total protein concentration, as an indicator of colostrum uptake. Results of <51 g/L indicated inadequate transfer of passive immunity (ITPI). The data showed that the incidence of ITPI on the farms was 6.5%, 31.3%, 48.8%, 49.7% and 52.4%. The incidence of ITPI was calculated in relation to the age of the calf at testing and the breed of calf, and no significant differences were found. A significant difference was found in the incidence of ITPI when comparing the calf’s first feed after separation from the dam (colostrum versus a colostrum-transition milk mixture). The farm with the lowest incidence of ITPI collected calves twice a day, measured colostrum quality on farm with a Brix refractometer and ensured that each calf received an appropriate amount of high-quality colostrum soon after collection. Further studies are required to establish the risk factors of ITPI in South Australian dairy heifers.

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“…Therefore, employing management practices to ensure that calves receive a sufficient volume of high-quality colostrum on their first day of life is critically important for calf health and future production (HUE et al, 2021). On this basis, colostrum is routinely stored before feeding, in which colostrum is kept in a refrigerator or freezer or at ambient temperatures for an extended period of time (CUMMINS et al, 2016b).…”

Section: úSuga Et Almentioning

confidence: 99%

Effect of three storage methods on physical and chemical properties of colostrum from Bos indicus cows

et al. 2022

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Maternal colostrum provides the neonate with immunoglobulins, essential for passive immunity. However, storage and handling of colostrum can alter its physical and nutritional characteristics. The aim of this study was to evaluate the effects of three conservation methods on colostrum density, pH, total antioxidant capacity (TAC), protein (PP) and lipid peroxidation (LP). Colostrum samples were collected from 15 Bos indicus cows, and divided into three aliquots for storage using three methods: refrigeration at 4°C, freezing at -20°C, and lyophilization. For each method, four evaluation times were performed: day (d) 5, 10, 15, and 20 for refrigeration and d 15, 30, 45, and 60 for freezing and lyophilization. pH and density analyses were performed at each evaluation time for each method. On d 0 and 15 of storage, TAC, LP, and PP analyses were performed. A generalized linear model, Tukey’s test for means comparisons, and a Pearson correlation analysis were conducted. A decrease in refrigerated colostrum pH was observed on d 15. Density of the lyophilized colostrum decreased, as compared with that of frozen colostrum. Lyophilization exhibited the lower PP values of samples, whereas refrigeration presented the highest values of LP and PP. No differences in colostrum TAC were observed between storage methods. A positive correlation between PP and colostrum density and a negative correlation between colostrum density and TAC were found. It was concluded that both freezing and lyophilization are suitable storage methods for bovine colostrum, as they limit proteins and lipids oxidation, and maintain the TAC of fresh colostrum.

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Colostrum source and passive immunity transfer in dairy bull calves

Cited by 15 publications

References 49 publications

Early flora colonization affects intestinal immunoglobulin G uptake in piglets, which may be mediated by NF-κB-FcRn pathway

Early flora colonization affects intestinal immunoglobulin G uptake in piglets, which may be mediated by NF-κB-FcRn pathway

Incidence of Inadequate Transfer of Passive Immunity in Dairy Heifer Calves in South Australia

Effect of three storage methods on physical and chemical properties of colostrum from Bos indicus cows

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