2022
DOI: 10.1177/08903344221087967
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Colostrum Use and the Immune System of Premature Newborns: A Systematic Review and Meta-Analysis

Abstract: Background: Human colostrum has been used in a number of investigations when preterm human infants cannot, for any reason, breastfeed directly from their mothers. One of the growing fields in these investigations is colostrum therapy, which consists of exposing the oropharyngeal mucosa of these preterm newborns to small amounts of raw colostrum. Research Aim: To critically review the scientific evidence about colostrum therapy in premature infants and to explore its influences on the immune system. Methods: Th… Show more

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“…This may relate to maternal immunity level. Because, when the gestational weeks increase the protective maternal antibodies and the neutrophil-mediated defenses decrease (Colonetti et al, 2022).…”
Section: Discussionmentioning
confidence: 99%
“…This may relate to maternal immunity level. Because, when the gestational weeks increase the protective maternal antibodies and the neutrophil-mediated defenses decrease (Colonetti et al, 2022).…”
Section: Discussionmentioning
confidence: 99%
“…An infant requires small volumes of colostrum (approximately mean 29 ml; SD 24 ml) over a 24-hour period in the days after birth until secretory activation occurs ( Perrella et al, 2021 ). Colostrum is nutrient-dense, rich in antibodies, and contains high levels of secretory Immunoglobulin A (IgA; Yang et al, 2018 ), which plays an important role in protecting infants from infection and providing immunity ( Colonetti et al, 2022 ) due to immature immune systems present in the infant at birth. There is currently inadequate research on the potential effect of early secretory activation on infant health.…”
Section: Discussionmentioning
confidence: 99%