Columnar cell carcinoma of the thyroid: MIB-1 immunoreactivity as a prognostic factor

Abstract

We report a case of columnar cell carcinoma of the thyroid. A 47-year-old Japanese man had a nonencapsulated thyroid mass that infiltrated the surrounding tissues extensively. Seventeen months after thyroidectomy he died of respiratory failure resulting from tracheal invasion. An autopsy showed distant metastases to the liver, lung, esophagus, and pancreas. Histologically, the thyroid mass consisted of tall columnar atypical cells with marked nuclear stratification, About one-fifth of tumor cells were immunopositive for M18-1. The MIB-1 -positive index of our case was extremely high, compared with that of ordinary papillary carcinoma. This case indicates that biological growth activity in columnar cell carcinoma may be similar to that of undifferentiated carcinoma of the thyroid, since the MIB-1 -positive index is close to each other.

Oncocytic papillary carcinoma with lymphoid stroma (Warthin‐like tumour) of the thyroid: a distinct entity with favourable prognosis

“…The MIB-1 index in our series is much lower than that in the aggressive variant of PC reported by Katoh et al 32,33 Our pathological findings (lymphoid stroma, low proliferative activity, S100 protein-positive dendritic/Langerhans cells) are compatible with the previously reported data associated with favourable biological behaviour of PC. [30][31][32][33] On the other hand, the strong membrane positivity of Leu-M1 in the neoplastic cells of all our cases must be taken into consideration. Schröder et al reported a strong correlation between Leu-M1 positivity in thyroid PC and its advanced clinical stage.…”

“…The average MIB‐1 index in our cases was approximately 3.5%, thus not differing significantly (analysis of variant test ( ANOVA ), P < 0.05) from the average MIB‐1 index in classical PC (3.9%) which we had found in a previous study of classical PC (unpublished data). The MIB‐1 index in our series is much lower than that in the aggressive variant of PC reported by Katoh et al 32 , 33 . Our pathological findings (lymphoid stroma, low proliferative activity, S100 protein‐positive dendritic/Langerhans cells) are compatible with the previously reported data associated with favourable biological behaviour of PC 30–33 .…”

“…Katoh et al . reported the MIB‐1 index of classical PC to be 1.83%, while identifying values of up to 20% in columnar cell carcinoma 32 , 33 . The average MIB‐1 index in our cases was approximately 3.5%, thus not differing significantly (analysis of variant test ( ANOVA ), P < 0.05) from the average MIB‐1 index in classical PC (3.9%) which we had found in a previous study of classical PC (unpublished data).…”

Clinicopathological and molecular characterization of nine cases of columnar cell variant of papillary thyroid carcinoma

“…Previous reports have documented an elevated mitotic index of 2-13 per 10 HPF and a Ki-67 labeling index of approximately 20% in aggressively behaving columnar cell carcinomas. 3,6,34,36,47 In this study, the overall Ki-67 index in columnar cell carcinoma was greater than that previously reported in conventional papillary thyroid carcinomas. 59,68 However, Ki-67 labeling of neoplasms presenting at low and high tumor staging was widely variable and overlapping; indolent tumors exhibited Ki-67 proliferation indices of up to 30%, whereas an aggressive tumor displayed a Ki-67 index of less than 5%.…”

“…Because previous studies of these neoplasms have been largely limited to case studies, we reviewed reports in the English literature to date to better define the clinicopathological characteristics of these rare neoplasms. [1][2][3][4][5][6][7][8][9][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48] The 48 reported cases consisted of 15 men and 33 women. Men ranged in age from 29 to 77 years (mean 49.5 years, median 47 years) and women from 16 to 83 years (mean 49 years, median 50 years).…”