Columnar cuff cancer after restorative proctocolectomy for familial adenomatous polyposis

Vuilleumier, Henri

doi:10.1136/gut.47.5.732

Cited by 36 publications

(23 citation statements)

References 15 publications

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“…There have already been three reported cases of cuff cancer in patients with FAP [9][10][11] . Regarding the anal transitional zone, two cancer cases have been reported [1] .…”

Section: Discussionmentioning

confidence: 99%

Development of Two Cancers in the Same Patient after Ileorectal and Ileal Pouch Anal Anastomosis for Familial Adenomatous Polyposis

Ulaş¹,

Neşşar²,

Bostanoğlu³

et al. 2005

Med Princ Pract

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Objective: To report a case of a patient with familial adenomatous polyposis. Clinical Presentation and Intervention: A 36-year-old male patient who suffered from rectal bleeding was treated with colectomy and ileorectal anastomosis for familial adenomatous polyposis (FAP) in 1974. After 19 years, in situ adenocarcinoma was detected in the rectal stump. Completion proctectomy, mucosectomy, and hand-sewn ileal pouch anal anastomosis with protective ileostomy were performed. In 2002, a metachronous cancer was detected at the anastomosis and abdominoperineal resection of the pouch and end ileostomy were performed. Later on, the perineum was excised locally because of cancer recurrence. Conclusion: This case shows that lifetime surveillance of the FAP patients after surgery is crucial.

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“…There have already been three reported cases of cuff cancer in patients with FAP [9][10][11] . Regarding the anal transitional zone, two cancer cases have been reported [1] .…”

Section: Discussionmentioning

confidence: 99%

Development of Two Cancers in the Same Patient after Ileorectal and Ileal Pouch Anal Anastomosis for Familial Adenomatous Polyposis

Ulaş¹,

Neşşar²,

Bostanoğlu³

et al. 2005

Med Princ Pract

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Section: Discussionmentioning

confidence: 99%

“…Seven of these pouches were performed for UC [1, 2, 3, 4, 5, 6, 7]and 3 for FAP [8, 9, 10]. The resultant cancer was histologically categorized as adenocarcinoma in 9 patients [1, 2, 3, 4, 6, 7, 8, 9, 10]and lymphoma in 1 [5]. The surgical technique in 8 cases was rectal mucosectomy with endorectal IPAA [1, 2, 3, 4, 5, 7, 8, 9]and non-mucosectomy stapled IPAA in 2 cases [6, 10].…”

Section: Discussionmentioning

confidence: 99%

Carcinoma of Pelvic Pouch following Restorative Proctocolectomy: Report of a Case and Review of the Literature

Negi¹,

Chaudhary²,

Gondal

2003

Dig Surg

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One of the possible long-term complications following an ileoanal pouch procedure is the development of malignancy in the mucosa of the rectal stump. Only 10 such cases have been reported so far. We report the case of a 23-year-old male who had ulcerative colitis with high-grade dysplasia and underwent an ileoanal pouch procedure. He was found to have a malignancy in the rectal stump 5 years after surgery. The malignancy presented with symptoms of refractory pouchitis. Pouch excision was performed. The risk of developing malignancy in the rectal mucosa after an ileoanal pouch procedure mandates regular follow-up in these patients, with a high index of suspicion especially in patients with delayed onset pouchitis.

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“…No obstante, tiene una tasa global de complicaciones del 24%, entre las que se describen la obstrucción de intestino delgado, la sepsis pélvica, la disfunción sexual masculina y femenina, el fallo del reservorio y la reservoritis (21-29) y no es desdeñable el riesgo de desarrollar pólipos neoplásicos y cáncer en el reservorio o en islotes de mucosa rectal retenidos, de los que hay ya numerosos casos descritos (9,(30)(31)(32)(33)(34)(35)(36)(37)(38).…”

Section: Discussionunclassified

Seguimiento posquirúrgico de los pacientes con poliposis adenomatosa familiar: resultados en una población del sur de España

Fernández

Moreno

Benavides

et al. 2007

Rev. esp. enferm. dig.

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INTRODUCCIÓNLa poliposis adenomatosa familiar (PAF) es una enfermedad hereditaria de carácter autosómico dominante, causada por una mutación en la línea germinal del gen APC (gen de la poliposis cólica), situado en el cromosoma 5q21 (1). Clásicamente la PAF se ha caracterizado por la presencia de más de 100 pólipos en el colon y recto, que de forma natural evolucionan indefectiblemente a carcinoma alrededor de la cuarta década de la vida.Para prevenir el desarrollo del cáncer sería necesario extirpar la mucosa del colon y recto en su totalidad. No existe actualmente un proceder único para lograr ese ob- RESUMENObjetivo: analizar la evolución de la mucosa rectal y del reservorio así como idoneidad de los intervalos de seguimiento y del tratamiento realizado para evitar la aparición del cáncer, en una serie de pacientes con poliposis adenomatosa familiar (PAF), intervenidos.Método: estudio prospectivo de 28 pacientes con PAF intervenidos mediante anastomosis íleo-rectal (20 pacientes) y anastomosis íleo-anal con reservorio (8 pacientes). A todos se les había realizado un control endoscópico dos veces al año y análisis del número y características macroscópicas e histológicas de los póli-pos antes y después de la cirugía así como del tratamiento realizado, de sus complicaciones y de la adecuación del intervalo de seguimiento. El seguimiento medio fue de 6,47 años (DE = 4,59; rango = 0,72-16,75 años).Resultados: ninguno de los 26 pacientes que cumplimentaron correctamente el protocolo de seguimiento desarrolló cáncer. Sólo dos pacientes lo desarrollaron al 1,75 y los 3 años, respectivamente del abandono del protocolo. Los pacientes que desarrollaron adenomas durante el seguimiento fueron tratados con éxito mediante polipectomía endoscópica, salvo en dos casos que se indicó cirugía.Conclusiones: en nuestra serie, el incumplimiento de las revisiones ha sido el factor que ha condicionado la aparición de cáncer.Palabras clave: Poliposis adenomatosa familiar. Anastomosis íleo-rectal. Anastomosis íleo-anal con reservorio ileal. Adenomas de colon. Seguimiento posquirúrgico. ABSTRACTObjective: the study was to assess changes in the rectal mucosa and pouch in a series of patients with familial adenomatous polyposis (FAP) who underwent either subtotal colectomy and ileorectal anastomosis (IRA) or proctocolectomy and ileal pouchanal anastomosis (IPAA), and to evaluate the suitability of the follow-up interval and postoperative treatment employed to prevent the development of cancer.Method: this study involved 28 patients with FAP who underwent IRA (n=20) or IPAA (n=8), and were followed endoscopically over a mean period of 7.47 years. The number and both macroscopic and histological features of polyps before and after surgery, the treatment, and complications were all analyzed. The suitability of the follow-up interval was assessed.Results: none of the 26 patients who complied with follow-up developed rectal cancer. Two patients developed rectal cancer at 21 and 36 months after withdrawing from the protocol. Except in two cas...

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Columnar cuff cancer after restorative proctocolectomy for familial adenomatous polyposis

Cited by 36 publications

References 15 publications

Development of Two Cancers in the Same Patient after Ileorectal and Ileal Pouch Anal Anastomosis for Familial Adenomatous Polyposis

Development of Two Cancers in the Same Patient after Ileorectal and Ileal Pouch Anal Anastomosis for Familial Adenomatous Polyposis

Carcinoma of Pelvic Pouch following Restorative Proctocolectomy: Report of a Case and Review of the Literature

Seguimiento posquirúrgico de los pacientes con poliposis adenomatosa familiar: resultados en una población del sur de España

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