Combating antibiotic resistance, mitigating future threats and ongoing initiatives

Velez, Roseann; Sloand, Elizabeth

doi:10.1111/jocn.13246

Cited by 30 publications

(15 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antimicrobial drug therapy is frequently associated with the emergence of resistance resulting in morbidity and mortality worldwide [1]. The difficult-to-treat multidrug resistance most commonly leads to a state of economic stress on the healthcare providers that indulge them to use broad spectrum antibiotics which is often unwarranted [2].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Anti-Microbial Effects of Low-Level Laser Irradiation and Microwave Diathermy on Gram-Positive and Gram-Negative Bacteria in an In Vitro Model

et al. 2019

View full text Add to dashboard Cite

Background and Objectives: The aim of this study was to compare the effects of low-level laser therapy and continuous microwave diathermy on the growth of Gram-negative and Gram-positive bacteria and to establish their efficacy as an alternative therapeutic modality. Materials and methods: Laser fluence of 13 Joules (J)/cm2, 18 J/cm2 and 30 J/cm2 were used against several bacterial strains. Microwave dosages of 25, 50 and 100 watts (W) were used, respectively. Results: A significant difference between the three groups was observed using repeated analysis of variance (RANOVA) (F value: 0.74, and p value: 0.001). The Greenhouse–Geisser correction (GG) revealed significant results for laser irradiation alone. However, effect size calculation showed effects with microwave diathermy as well as laser fluence. Conclusions: Low-level laser therapy appears to be an effective modality of treatment when compared with continuous microwave diathermy on the Gram-negative and the Gram-positive bacterial strains tested. Microwave diathermy revealed large and medium effects on the bacterial cell counts with dominant effects on Gram-negative strains.

show abstract

Section: Introductionmentioning

confidence: 99%

Comparison of Anti-Microbial Effects of Low-Level Laser Irradiation and Microwave Diathermy on Gram-Positive and Gram-Negative Bacteria in an In Vitro Model

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Antibiotic resistance causes prolonged illness, excess mortality, and higher costs for patients and health systems [ 7 , 8 , 9 ]. Despite increased warnings and numerous efforts to contain it, antibiotic resistance has been increasing [ 10 , 11 , 12 , 13 ]. At the recent United Nations general assembly, it was highlighted that antibiotic resistance is among the greatest global health risks, requiring urgent attention [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Antibiotic Resistance and Antibiotic Resistance Genes in Escherichia coli Isolates from Hospital Wastewater in Vietnam

Lien

Lan

Chúc

et al. 2017

IJERPH

View full text Add to dashboard Cite

The environmental spread of antibiotic-resistant bacteria has been recognised as a growing public health threat for which hospitals play a significant role. The aims of this study were to investigate the prevalence of antibiotic resistance and antibiotic resistance genes (ARGs) in Escherichia coli isolates from hospital wastewater in Vietnam. Wastewater samples before and after treatment were collected using continuous sampling every month over a year. Standard disk diffusion and E-test were used for antibiotic susceptibility testing. Extended-spectrum beta-lactamase (ESBL) production was tested using combined disk diffusion. ARGs were detected by polymerase chain reactions. Resistance to at least one antibiotic was detected in 83% of isolates; multidrug resistance was found in 32%. The highest resistance prevalence was found for co-trimoxazole (70%) and the lowest for imipenem (1%). Forty-three percent of isolates were ESBL-producing, with the blaTEM gene being more common than blaCTX-M. Co-harbouring of the blaCTX-M, blaTEM and qepA genes was found in 46% of isolates resistant to ciprofloxacin. The large presence of antibiotic-resistant E. coli isolates combined with ARGs in hospital wastewater, even post-treatment, poses a threat to public health. It highlights the need to develop effective processes for hospital wastewater treatment plants to eliminate antibiotic resistant bacteria and ARGs.

show abstract

“…Antimicrobial resistance is increasingly a threat to global public health [1]. AMR-related infections limit the efficacy of lifesaving antibiotic therapy necessary for the treatment of infectious disease and limit the success of advanced surgical procedures like organ transplants [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Similarly, it is estimated that 426,000 infections and 33,000 deaths from antimicrobial resistant microorganisms occur in the European Union every year [5]. Furthermore, AMR places a considerable medical and financial burden on global societies and health care systems as a whole [1,3,[6][7][8]. It is therefore essential to develop a better understanding of the cause and spread of AMR around the world.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Incidents and Trends of Antimicrobial Resistance in Foodborne Pathogens in Eight Countries from Historical Sample Data

Yang

Wang

et al. 2020

IJERPH

View full text Add to dashboard Cite

Antimicrobial resistance (AMR) causes millions of illnesses every year, threatening the success of lifesaving antibiotic therapy and, thus, public health. To examine the rise and spread of antimicrobial resistance around the world, our study performs a multivariate statistical analysis of antimicrobial resistance gene data from eight different countries: the US, the UK, China, Brazil, Mexico, Canada, Australia, and South Africa. Multi-dimensional data points were projected onto a two-dimensional plane using principal component analysis and organized into a dendrogram utilizing hierarchical clustering to identify significant AMR genes and pathogens. Outlier genes/pathogens were typically involved in high occurrences of antimicrobial resistance, and they were able to indicate the trend of antimicrobial resistance in the future. Statistical analysis of the data identified: (1) tet(A), aph(3″)-Ib, aph(6)-Id, blaEC, blaTEM-1, qacEdelta1, sul1, sul2, and aadA1 as the nine most common AMR genes among the studied countries; (2) Salmonella enterica and E. coli and Shigella as the most common AMR foodborne pathogens; and (3) chicken as the most prevalent meat carrier of antimicrobial resistance. Our study shows that the overall number of reported antimicrobial resistance cases in foodborne pathogens is generally rising. One potential contributing factor for this is the increasing antimicrobial usage in the growing livestock industry.

show abstract

Combating antibiotic resistance, mitigating future threats and ongoing initiatives

Abstract: This article emphasises the complexity of antibiotic resistance and highlights the need for a multifaceted approach to improve health care outcomes.

Cited by 30 publications

References 15 publications

Comparison of Anti-Microbial Effects of Low-Level Laser Irradiation and Microwave Diathermy on Gram-Positive and Gram-Negative Bacteria in an In Vitro Model

Comparison of Anti-Microbial Effects of Low-Level Laser Irradiation and Microwave Diathermy on Gram-Positive and Gram-Negative Bacteria in an In Vitro Model

Antibiotic Resistance and Antibiotic Resistance Genes in Escherichia coli Isolates from Hospital Wastewater in Vietnam

Investigation of Incidents and Trends of Antimicrobial Resistance in Foodborne Pathogens in Eight Countries from Historical Sample Data

Contact Info

Product

Resources

About