Combating bacterial biofilms and related drug resistance: Role of phyto-derived adjuvant and nanomaterials

Kungwani, Neelam Amit; Panda, Jibanjyoti; Mishra, Awdhesh Kumar; Chavda, Nilam; Shukla, Sudhir; Vikhe, Kalyani; Sharma, Gunjan; Mohanta, Yugal Kishore; Sharifi-Rad, Majid

doi:10.1016/j.micpath.2024.106874

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Cited by 3 publications

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Intersection of artificial intelligence, microbes, and bone and joint infections: a new frontier for improving management outcomes

Imam,

Abdelrahman,

Zumla

et al. 2024

The Lancet Microbe

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Intersection of artificial intelligence, microbes, and bone and joint infections: a new frontier for improving management outcomes

Imam,

Abdelrahman,

Zumla

et al. 2024

The Lancet Microbe

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Combating dental biofilms using plant-derived flavonoids: a simple and potential therapeutic approach

Venkatesan,

Gunasekaran,

Sathishkumar

2024

Natural Product Research

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Functional Hydrogels Promote Chronic Infectious Wound Healing by Re-rousing Macrophage M1 and Inducing Bacterial Copper-Like Death

Xiang,

Pu,

Zhong

et al. 2024

Preprint

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Background: Traditional antibiotics are often ineffective against biofilm-associated infections, and biofilm-induced macrophage immune evasion directly halts the wound healing process. Disrupting biofilms and regulating macrophage immune functions are critical to improving wound healing. Results: In this study, we synthesized g-C3N4 with peroxidase (POD) enzyme activity via thermal polymerization and copper alginate microspheres (CAM) via gas cutting. These were co-encapsulated into GelMA hydrogels to form a functionalized wound repair system (GelMA/CAM@g-C3N4) with both anti-biofilm and local immune microenvironment remodeling capabilities. In vitro, this system exhibited excellent biocompatibility and promoted endothelial cell migration, vascular formation, and CD31 expression. It also polarized macrophages toward the M1 phenotype, restoring their pro-inflammatory functions, upregulating inflammatory cytokines (IL-1, IL-6, TNF-α), and inhibiting Staphylococcus aureus and Escherichia coli. In vivo, the system suppressed S. aureus growth, promoted angiogenesis and collagen deposition, and reshaped the pathological microenvironment to achieve wound repair and regeneration. Conclusions: This system offers a new therapeutic strategy for chronic infectious wounds.

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Combating bacterial biofilms and related drug resistance: Role of phyto-derived adjuvant and nanomaterials

Cited by 3 publications

References 231 publications

Intersection of artificial intelligence, microbes, and bone and joint infections: a new frontier for improving management outcomes

Intersection of artificial intelligence, microbes, and bone and joint infections: a new frontier for improving management outcomes

Combating dental biofilms using plant-derived flavonoids: a simple and potential therapeutic approach

Functional Hydrogels Promote Chronic Infectious Wound Healing by Re-rousing Macrophage M1 and Inducing Bacterial Copper-Like Death

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