Combating devastating COVID-19 by drug repurposing

Pawar, Ashish Y.

doi:10.1016/j.ijantimicag.2020.105984

Cited by 72 publications

(56 citation statements)

References 18 publications

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“…However, the percentage retaining mechanical strength after subsequent washing is an interesting fact that needs to be evaluated (70). Due course of time, the health department of different countries and WHO provides various preventive health care memos in the public domain that could help to restrict the spreadability of CoVID-19 infection worldwide and are mentioned in Figure 3 (71,72).…”

Section: Face Mask/respiratorsmentioning

confidence: 99%

A Review of Current Interventions for COVID-19 Prevention

Pradhan

Biswasroy

Naik

et al. 2020

Archives of Medical Research

298

229

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The recent outbreak of CoVID-19 is declared as a global public health emergency of international concern by the World Health Organization (WHO). A fresh figure of 2268011 positive cases and 155185 death records (till April 18 th 2020) across the worldwide signify the severity of this viral infection. CoVID-19 infection is a pandemic, surface to surface communicable disease with a case fatality rate of 3.4% as estimated by WHO up to March 3 rd 2020. Unfortunately, the current unavailability of an effective antiviral drug and approved vaccine, worsen the situation more critical. Implementation of an effective preventive measure is the only option left to counteract CoVID-19. Further, a retrospective analysis provides evidence that contemplates the decisive role of preventive measures in controlling severe acute respiratory syndrome (SARS) outbreak in 2003. A statistical surveillance report of WHO reflects, maintaining a coherent infection, prevention and control guideline resulted in a 30% reduction in healthcare-associated infections. The effectiveness of preventive measures completely relies on the strength of surface disinfectants, the composition of hand sanitizer, appropriate material for the manufacture of personal protective equipment (PPE). This review enlightens the various preventive measures such as a suitable selection of surface disinfectants, appropriate hand sanitization, and empowering the PPE that could be a potential intervention to fight against CoVID-19.

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Section: Face Mask/respiratorsmentioning

confidence: 99%

A Review of Current Interventions for COVID-19 Prevention

Pradhan

Biswasroy

Naik

et al. 2020

Archives of Medical Research

298

229

View full text Add to dashboard Cite

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“…The drugs like Chloroquine, Hydroxychloroquine and Remdesivir [9] were reported to be effective in some studies, but not efficacious in critically ill and aged patients of COVID-19. The patients with diabetes or any other severe underlying condition may develop serious respiratory diseases if infected with the COVID-19 infection.…”

Section: Introductionmentioning

confidence: 99%

Convalescent plasma: A possible treatment protocol for COVID- 19 patients suffering from diabetes or underlying liver diseases

Pawar¹,

Hiray

Sonawane

et al. 2020

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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Background & Aim: As on date, no specific treatment is available for devastating COVID-19 (SARS-CoV-2) infection. This pandemic viral infection has affected over 200 countries within a very short time and created a calamitous situation across the globe. As per WHO guidelines, the treatment is mainly symptomatic and supportive. This clinical protocol has not proven sufficient to save the lives of COVID-19 patients suffering from diabetes or having underlying liver diseases; hence there is utmost need to tackle this situation by other means such as Convalescent Plasma (CP) therapy. Methods: A comprehensive literature survey was carriedout using Elsevier, PubMed, Taylor & Francis, Springer, Nature and Google search engines. Results: The patients suffering from diabetes or liver dysfunction or any other underlying diseases are at greatest risk of SARS-CoV-2 infection. From the study, it is proved that plasma collected from the recovered patients of viral infection has considerable potential to treat the viral disease without the occurrence of adverse effects. Conclusion: The CP therapy can be a possible life saving alternative to treat critical COVID-19 patients having diabetes or underlying liver dysfunction. Hence, randomised clinical trials are recommended at the earliest to save the lives of infected individuals of COVID-19.

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“…Drug repurposing is one such strategy which is being extensively used worldwide to design vaccines against this coronavirus [8][9][10][11]. To understand how similar is the SARS-nCoV2 in comparison to the earlier coronaviruses sequence comparison studies have been performed to understand the variation in the sequence of these potential target proteins [12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Drug Repurposing Studies Targeting SARS-nCoV2: An Ensemble Docking Approach on Drug Target 3C-like Protease (3CLpro)

Koulgi¹,

Jani²,

Uppuladinne³

et al. 2020

Preprint

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The COVID-19 pandemic has been responsible for several deaths worldwide. The causative agent behind this disease is the Severe Acute Respiratory Syndrome – novel Coronavirus 2 (SARS-nCoV2). SARS-nCoV2 belongs to the category of RNA viruses. The main protease, responsible for the cleavage of the viral polyprotein is considered as one of the hot targets for treating COVID-19. Earlier reports suggest the use of HIV anti-viral drugs for targeting the main protease of SARS-CoV, which caused SARS in the year 2002-03. Hence, drug repurposing approach may prove to be useful in targeting the main protease of SARS-nCoV2. The high-resolution crystal structure of 3CLpro (main protease) of SARS-nCoV2 (PDB ID: 6LU7) was used as the target. The Food and Drug Administration (FDA) approved and SWEETLEAD database of drug molecules were screened. The apo form of the main protease was simulated for a cumulative of 150 ns and 10 μs open source simulation data was used, to obtain conformations for ensemble docking. The representative structures for docking were selected using RMSD-based clustering and Markov State Modeling analysis. This ensemble docking approach for main protease helped in exploring the conformational variation in the drug binding site of the main protease leading to efficient binding of more relevant drug molecules. The drugs obtained as best hits from the ensemble docking possessed anti-bacterial and anti-viral properties. Small molecules with these properties may prove to be useful to treat symptoms exhibited in COVID-19. This in-silico ensemble docking approach would support identification of potential candidates for repurposing against COVID-19.

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Combating devastating COVID-19 by drug repurposing

Cited by 72 publications

References 18 publications

A Review of Current Interventions for COVID-19 Prevention

A Review of Current Interventions for COVID-19 Prevention

Convalescent plasma: A possible treatment protocol for COVID- 19 patients suffering from diabetes or underlying liver diseases

Drug Repurposing Studies Targeting SARS-nCoV2: An Ensemble Docking Approach on Drug Target 3C-like Protease (3CLpro)

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