Combating influenza: natural products as neuraminidase inhibitors

Singh, Nisha; Anjum, Nawed; Chandra, Ramesh

doi:10.1007/s11101-018-9581-1

Cited by 12 publications

(13 citation statements)

References 123 publications

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“…Instead, it describes the sialidase inhibitors based on their inhibition mechanisms, including (i) transition-state analogue inhibitors, (ii) mechanism-based inhibitors, (iii) suicide substrate inhibitors, (iv) product analogue inhibitors, and (v) natural product inhibitors. More detailed information about specific sialidase inhibitors from the past decade can be found in comprehensive reviews. ,− …”

Section: Discussionmentioning

confidence: 99%

“…More detailed information about various natural neuraminidase inhibitors and neuraminidase inhibition assays can be found in these two comprehensive reviews. 148,149 Overall, natural compounds may serve as good lead structures for the discovery and development of potent viral neuraminidase inhibitors. Natural Product Bacterial Sialidase Inhibitors.…”

Section: Transition-state Analogue Human Sialidase Inhibitorsmentioning

confidence: 92%

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Sialidase Inhibitors with Different Mechanisms

et al. 2022

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Sialidases, or neuraminidases, are enzymes that catalyze the hydrolysis of sialic acid (Sia)-containing molecules, mostly removal of the terminal Sia (desialylation). By desialylation, sialidase can modulate the functionality of the target compound and is thus often involved in biological pathways. Inhibition of sialidases with inhibitors is an important approach for understanding sialidase function and the underlying mechanisms and could serve as a therapeutic approach as well. Transition-state analogues, such as anti-influenza drugs oseltamivir and zanamivir, are major sialidase inhibitors. In addition, difluoro-sialic acids were developed as mechanism-based sialidase inhibitors. Further, fluorinated quinone methide-based suicide substrates were reported. Sialidase product analogue inhibitors were also explored. Finally, natural products have shown competitive inhibiton against viral, bacterial, and human sialidases. This Perspective describes sialidase inhibitors with different mechanisms and their activities and future potential, which include transition-state analogue inhibitors, mechanism-based inhibitors, suicide substrate inhibitors, product analogue inhibitors, and natural product inhibitors.

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Section: Discussionmentioning

confidence: 99%

Section: Transition-state Analogue Human Sialidase Inhibitorsmentioning

confidence: 92%

Sialidase Inhibitors with Different Mechanisms

et al. 2022

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“…Neuraminidase is a crucial enzyme for viral replication and is the most promising target for the new drugs. Chandra and co-workers 135 have reported the update on neuraminidase enzyme highlighting its structure, function, mechanism and inhibition by natural products, which will be helpful in the discovery of antiviral agents in the future. Some experimental studies have reported that tea catechins may inhibit influenza viral adsorption and suppressed replication and neuraminidase activity.…”

Section: Neuraminidase Inhibitors (Nais)mentioning

confidence: 99%

Recent progress in chemical approaches for the development of novel neuraminidase inhibitors

et al. 2021

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“…In history several flu pandemics have occurred such as ten years ago when millions of people were infected in more than 214 countries by S-OIV H1N1 (a new influenza virus). 32,33 Influenza viruses belong to the family Orthomyxoviridae of enveloped viruses that have been classified into four types, A, B, C and the recently identified type D. 34 All of them are enveloped negative-sense-single-strand RNA viruses with a segmented genome. The influenza A virus and B virus both contain hemagglutinin (HA) and neuraminidase (NA) proteins on their surface.…”

Section: Influenza Virusesmentioning

confidence: 99%

Multivalency effects in neuraminidase inhibitor design for influenza virus

Wei¹,

Pieters²

2021

Arkivoc

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Multivalent interactions exist everywhere in nature. Here we will summarize the available data of multivalency effects that were explored for the design of novel neuraminidase (NA) inhibitors of influenza virus A. Although multivalency is a most effective tool to achieve high binding affinity, the molecular mechanisms are still poorly understood. The potency of multivalent neuraminidase inhibitors (NAIs) are dependent on the length, rigidity and chemical composition of the linker, ligand chemical structure and also the density of the ligand display. Important issues such as potential side-effects, drug-resistance, bioavailability and pharmacokinetics are largely unexplored with respect to application. The multivalent NAIs reported so far were of surprising potency and may play a role in therapeutic application and may prove valuable in forecasted pandemics .

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Combating influenza: natural products as neuraminidase inhibitors

Cited by 12 publications

References 123 publications

Sialidase Inhibitors with Different Mechanisms

Sialidase Inhibitors with Different Mechanisms

Recent progress in chemical approaches for the development of novel neuraminidase inhibitors

Multivalency effects in neuraminidase inhibitor design for influenza virus

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