Combating oxidative stress disorders with citrus flavonoid: Naringenin

Zaidun, Nurul Hannim; Thent, Zar Chi; Latiff, Azian Abd

doi:10.1016/j.lfs.2018.07.017

Cited by 175 publications

(102 citation statements)

References 101 publications

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“…Therefore, T. orientalis aqueous infusion extract which is a good source of tannins may possess significant anticancer activity and antioxidant potentials. In recent years, several clinical trials,-as well as other evidences have indicate that diseases precipitated by oxidative stress can be prevented or managed with high flavonoids rich foods (30)(31)(32). Previous studies by Özen (33) report a phenolic content of 82.1±1.5 mg pyrocatechol/g dry weight of T. orientalis.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Activity, Total Phenol and Total Flavonoid Contents of Trachystemon orientalis (L.) G. Don

Saçan¹

2019

Eur J Biol

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For many years, plants have been considered a source of alternative medicine and are used for the treatment of several diseases. These medicinal plants are excellent sources of phytochemicals and antioxidant activity. Trachystemon orientalis (L.) G. Don (Boraginaceae) originates from East Bulgaria but can be found mostly in West Caucasia and the Black Sea region of Turkey. Its flowering branches, rhizomes, and leaves are used as food. Materials and Methods: The antioxidant activity of a T. orientalis aqueous infusion was investigated using various antioxidant tests, such as reducing power and radical scavenging activity. The phenolic and flavonoid contents were also determined. Results were compared with natural and synthetic antioxidants. Results: The results demonstrated that T. orientalis (L.) is a good source of antioxidants. Conclusion: This study suggested that T. orientalis extract can be considered a useful natural antioxidant source because of its flavonoid, phenolic, and anthocyanin contents. The food and cosmetic industries might employ T. orientalis extract as an alternative additive to other highly toxic synthetic antioxidants.

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Section: Discussionmentioning

confidence: 99%

Antioxidant Activity, Total Phenol and Total Flavonoid Contents of Trachystemon orientalis (L.) G. Don

Saçan¹

2019

Eur J Biol

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“…In prostate cancer PC3 and LNCaP cell lines, naringenin suppressed proliferation and migration and induced apoptosis and ROS generation [67]. Furthermore, naringenin reduced ROS generation and enhanced the activity of superoxide dismutase, catalase, glutathione in chronic diseases and cancer [68]. Cocoa catechins and procyanidins have been shown to induce apoptotic morphological changes, DNA damage and apoptosis in epithelial ovarian cancer cells due to their prooxidant properties [69].…”

Section: Flavonoids In Oxidative Stressmentioning

confidence: 99%

Flavonoids as Anticancer Agents

et al. 2020

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Flavonoids are polyphenolic compounds subdivided into 6 groups: isoflavonoids, flavanones, flavanols, flavonols, flavones and anthocyanidins found in a variety of plants. Fruits, vegetables, plant-derived beverages such as green tea, wine and cocoa-based products are the main dietary sources of flavonoids. Flavonoids have been shown to possess a wide variety of anticancer effects: they modulate reactive oxygen species (ROS)-scavenging enzyme activities, participate in arresting the cell cycle, induce apoptosis, autophagy, and suppress cancer cell proliferation and invasiveness. Flavonoids have dual action regarding ROS homeostasis—they act as antioxidants under normal conditions and are potent pro-oxidants in cancer cells triggering the apoptotic pathways and downregulating pro-inflammatory signaling pathways. This article reviews the biochemical properties and bioavailability of flavonoids, their anticancer activity and its mechanisms of action.

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“…Nutraceuticals may represent a complementary or adjunct alternative to drugs prescribed in the treatment of prediabetes. Eriomin®, a supplement of citrus flavonoids, composed of eriocitrin, hesperidin, and naringin, has been shown to have anti-inflammatory, antihyperglycemic, and antioxidant properties (Minato et al, 2003;Miyake et al, 2006;Zaidun, Thent, & Latiff, 2018). Experimental mice (C57BL/6 J) supplemented with eriocitrin (140 mg/kg/day) showed an increase of total antioxidant capacity and decreased inflammatory markers (IL-6, MCP-1, and hsPCR) in the blood circulating and organs (Ferreira, Spolidorio, Manthey, & Cesar, 2016).…”

mentioning

confidence: 99%

Effectiveness of Eriomin® in managing hyperglycemia and reversal of prediabetes condition: A double‐blind, randomized, controlled study

Ribeiro

Ramos

Manthey

et al. 2019

Phytotherapy Research

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This study evaluated the potential effectiveness of different doses of Eriomin® on hyperglycemia and insulin resistance associated with other metabolic biomarkers in prediabetic individuals. Prediabetes patients ( n = 103, 49 ± 10 years) were randomly divided into four parallel groups: (a) Placebo; (b) Eriomin 200 mg; (c) Eriomin 400 mg; and (d) Eriomin 800 mg. Assessment of biochemical, metabolic, inflammatory, hepatic, renal, anthropometric markers, blood pressure, and dietary parameters were performed during 12 weeks of intervention. Treatment with all doses of Eriomin (200, 400, and 800 mg) had similar effects and altered significantly the following variables: blood glucose (−5%), insulin resistance (−7%), glucose intolerance (−7%), glycated hemoglobin (−2%), glucagon (−6.5%), C‐peptide (−5%), hsCRP (−12%), interleukin‐6 (−13%), TNFα (−11%), lipid peroxidation (−17%), systolic blood pressure (−8%), GLP‐1 (+15%), adiponectin (+19%), and antioxidant capacity (+6%). Eriomin or placebo did not influence the anthropometric and dietary variables. Short‐term intervention with Eriomin, at doses of 200, 400, or 800 mg/day, benefited glycemic control, reduced systemic inflammation and oxidative stress, and reversed the prediabetic condition in 24% of the evaluated patients.

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Combating oxidative stress disorders with citrus flavonoid: Naringenin

Cited by 175 publications

References 101 publications

Antioxidant Activity, Total Phenol and Total Flavonoid Contents of Trachystemon orientalis (L.) G. Don

Antioxidant Activity, Total Phenol and Total Flavonoid Contents of Trachystemon orientalis (L.) G. Don

Flavonoids as Anticancer Agents

Effectiveness of Eriomin® in managing hyperglycemia and reversal of prediabetes condition: A double‐blind, randomized, controlled study

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