2006
DOI: 10.1517/13543784.15.4.339
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Combating psychosis in Parkinson’s disease patients: the use of antipsychotic drugs

Abstract: Parkinson's disease (PD) patients commonly experience psychotic symptoms, with the most frequent manifestation being visual hallucinations. In PD, psychosis is predominantly drug induced and an important issue for clinicians to address as it increases the risk of nursing home placement as well as mortality. This review summarises the current knowledge regarding the clinical manifestations, pathophysiology and risk factors for drug-induced psychosis in patients with PD and focuses on treatment, especially with … Show more

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Cited by 10 publications
(5 citation statements)
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“…59 Based on the experience of polypharmacy in the treatment of epilepsy, most researchers 5759 believe that it is better to reduce and then eliminate as many drugs as possible rather than maintaining low doses of several drugs. Virtually all Parkinson's disease experts 71 would recommend stopping anticholinergic medication first. The other drugs, in the order of stopping priority, are amantadine and monoamine oxidase inhibitors, dopamine agonists, and then, L-dopa.…”
Section: Psychosismentioning
confidence: 99%
“…59 Based on the experience of polypharmacy in the treatment of epilepsy, most researchers 5759 believe that it is better to reduce and then eliminate as many drugs as possible rather than maintaining low doses of several drugs. Virtually all Parkinson's disease experts 71 would recommend stopping anticholinergic medication first. The other drugs, in the order of stopping priority, are amantadine and monoamine oxidase inhibitors, dopamine agonists, and then, L-dopa.…”
Section: Psychosismentioning
confidence: 99%
“…Hallucinations occur in 20–40% of Parkinson's disease (PD) patients receiving symptomatic therapy [ 1 ]. Although potentially treatable by anti-parkinsonian drug adjustments and the use of atypical antipsychotics [ 2 ], hallucinations have been associated with unfavorable clinical outcomes such as nursing home placement and increased mortality [ 3 , 4 ].…”
Section: Introductionmentioning
confidence: 99%
“…50,63 It is the single greatest risk factor for nursing home placement in patients with PD and contributes to caregiver stress. 64 The most common manifestations of psychosis in PD are visual hallucinations. 63,65 Non-visual hallucinations (auditory, tactile, olfactory) and delusions may also be present, though less frequently.…”
Section: Psychosismentioning
confidence: 99%