Combination chemotherapy with 1-(2-chloroethyl-3-cyclohexyl-1-nitrosourea) (CCNU), vincristine and methotrexate in primary and metastatic brain tumors—A preliminary report

Hildebrand, Jerzy; Brihaye, J; Wagenknecht, L.; Michel, Jeffrey; Kenis, Yvon

doi:10.1016/0014-2964(73)90004-2

Cited by 28 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The lipophilic nitrosourea derivatives are able to penetrate the barrier (Shapiro et aI. 1970) and can produce objective remissions in patients with recurrent gliomas (Wilson et al 1970, Walker and Hurwitz 1970, Hansen et al 1971, Rosenblum et al 1972, Hildebrand et al 1973, Calogero et al 1975. A significant prolongation of survival in a group of patients was only attained when these substances were combined with radiation therapy Gehan 1972, Armentrout et aI.…”

Section: Discussionmentioning

confidence: 96%

Chemotherapy of malignant gliomas: Comparison of the effect of polychemo- and CCNU-therapy

Heiss

1978

Acta neurochir

View full text Add to dashboard Cite

Postoperative survival times of patients suffering from glioblastoma (astrozytoma III-IV) were compared in unselected groups receiving different forms of therapy: standard surgical therapy (16 cases, mean survival time 6.27 +/- 3.75 months), postoperative polychemotherapy (16 patients, survival time 8.96 +/- 4.97 months) or postoperative CCNU-monotherapy (24 cases, survival time 6.98 +/- 4.46 months). The mean survival time in the group receiving polychemotherapy was prolonged significantly when compared to the group with standard treatment. Survival time of the patient group treated with CCNU was not significantly increased. The results indicate that postoperative combination chemotherapy is more effective than CCNU monotherapy.

show abstract

Section: Discussionmentioning

confidence: 96%

Chemotherapy of malignant gliomas: Comparison of the effect of polychemo- and CCNU-therapy

Heiss

1978

Acta neurochir

View full text Add to dashboard Cite

show abstract

Combined modality therapy for intracranial tumors

Bloom

1975

Cancer

123

View full text Add to dashboard Cite

Three types of tumor (supratentorial astrocytoma, mednlloblastoma, and craniopharyngioma), each requiring a fundamentally different therapeutic approach, will be used to illustrate the principles and practice of combined treatment in this field. The role of radiotherapy and ways of enhancing the effect of irradiation will be considered. Attention will be given to adjuvant chemotherapy and to multiple drug regimes. Reference will he made to an early effort at immunotherapy following the initial reduction of tumor cell load by surgery and irradiation.Cancer 35: 1 1 1-120, 1975. N ASSESSING RESULTS OF TREATING CEREHRAI.

show abstract

Treatment of malignant gliomas and brain metastases in adults with a combination of adriamycin, VM 26, and CCNU.Results of a phase II trial

Pouillart

Mathé

Thy

et al. 1976

Cancer

View full text Add to dashboard Cite

Forty-three patients with inoperable or recurring malignant gliomas, and 30 patients with multiple recurring brain metastases were treated with a combination of Adriamycin (45 mg/m2) and 4-dimethyl-epipodophyllotoxin D-thenylidene (VM 26) (60 mg/m2 for 2 days) with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (60 mg/m2 for 2 days). These cycles of treatment were repeated as soon as the hematologic restoration was complete. The treatment was well tolerated and the clinical condition of 31 of 43 glioblastoma patients improved during the 2 months after the beginning of the treatment. Six of eight patients with breast cancer metastases, one of 13 with bronchial cancer matastases, and three of nine with other types of cancer metastases also benefitted from the treatment. Examination of the results obtained revealed the following characteristics: 1) This combination had a low degree of efficiency in the treatment of metastases to brain, except for breast cancer metastases; 2) there was no complete correlation between the clinical results observed and the cinegammagraphic developments; 3) the results obtained were similar, independent of the initial localization; and a 6-month median survival period was established, with 10 patients now in a state of apparently complete remission, 180 to 506 days after beginning of the treatment.

show abstract

Combination chemotherapy with 1-(2-chloroethyl-3-cyclohexyl-1-nitrosourea) (CCNU), vincristine and methotrexate in primary and metastatic brain tumors—A preliminary report

Cited by 28 publications

References 7 publications

Chemotherapy of malignant gliomas: Comparison of the effect of polychemo- and CCNU-therapy

Chemotherapy of malignant gliomas: Comparison of the effect of polychemo- and CCNU-therapy

Combined modality therapy for intracranial tumors

Treatment of malignant gliomas and brain metastases in adults with a combination of adriamycin, VM 26, and CCNU.Results of a phase II trial

Contact Info

Product

Resources

About