Combination effect naringin and pravastatin in lipid profile and glucose in obese rats

Raffoul-Orozco, Abdel K.; Ávila-González, Ana E.; Rodríguez-Razón, Christian M.; Cobián, Teresa Arcelia García; Pérez-Guerrero, Edsaúl Emilio; García-Iglesias, Trinidad; Arellano, Edy David Rubio

doi:10.1016/j.lfs.2017.11.044

Cited by 11 publications

(4 citation statements)

References 21 publications

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“…Future studies, non-clinical or clinical, should also include parallel monitoring of key markers of both mitochondrial and peroxisome lipid oxidation pathways. Furthermore, a combination with statins, as a few recent experimental approaches suggest ( 49 ), might elucidate naringin’s role in other valproate metabolic and obesity research models.…”

Section: Discussionmentioning

confidence: 99%

Effects of naringin and valproate interaction on liver steatosis and dyslipidaemia parameters in male C57BL6 mice

Jutrić

Đikić

Boroš

et al. 2022

Archives of Industrial Hygiene and Toxicology

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Valproate is a common antiepileptic drug whose adverse effects include liver steatosis and dyslipidaemia. The aim of our study was to see how natural flavonoid antioxidant naringin would interact with valproate and attenuate these adverse effects. For this reason we treated male C57BL6 mice with a combination of 150 mg/kg of valproate and 25 mg/kg naringin every day for 10 days and compared their serum triglycerides, cholesterol, LDL, HDL, VLDL, and liver PPAR-alpha, PGC-1 alpha, ACOX1, Nrf2, SOD, CAT, GSH, and histological signs of steatosis. Valproate increased lipid peroxidation parameters and caused pronounced microvesicular steatosis throughout the hepatic lobule in all acinar zones, but naringin co-administration limited steatosis to the lobule periphery. In addition, it nearly restored total serum cholesterol, LDL, and triglycerides and liver ACOX1 and MDA to control levels. and upregulated PPAR-alpha and PGC-1 alpha, otherwise severely downregulated by valproate. It also increased SOD activity. All these findings suggest that naringin modulates key lipid metabolism regulators and should further be investigated in this model, either alone or combined with other lipid regulating drugs or molecules.

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Section: Discussionmentioning

confidence: 99%

Effects of naringin and valproate interaction on liver steatosis and dyslipidaemia parameters in male C57BL6 mice

Jutrić

Đikić

Boroš

et al. 2022

Archives of Industrial Hygiene and Toxicology

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“…NAR, a Chinese herbal medicine, is widely found in citrus plants and possesses great health benefits (Liu et al, 2020). NAR may be a potential treatment for NAFLD because of its antilipidemic effects (Raffoul-Orozco et al, 2018;Zhou et al, 2019), but how NAR acts on lipid accumulation remains uncertain.…”

Section: Discussionmentioning

confidence: 99%

“…Naringin (NAR), a principal flavanone enriched in citrus fruits, appears to reduce hepatic lipid accumulation (Raffoul-Orozco et al, 2018;Zhou et al, 2019), giving it great therapeutic potential for treating NAFLD. NAR is reported to exhibit antihyperglycemic and antioxidant properties (Ahmed et al, 2017;Rotimi et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Naringin Attenuates High Fat Diet Induced Non-alcoholic Fatty Liver Disease and Gut Bacterial Dysbiosis in Mice

et al. 2020

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“…Its metabolite naringenin is ubiquitously distributed in plant foods and traditional Chinese medicines. Both NG and its metabolite naringenin have been reported to show broad spectrum of therapeutic and pharmacological properties including anti-inflammatory [26][27][28][29][30], free radical-scavenging [31][32][33], lipid-lowering [34,35], antioxidant [36][37][38][39], anti-fibrosis, and anti-obesity effects [34,35,40]. Recently, NG has been extensively checked for its antioxidant property in different animal models.…”

Section: Introductionmentioning

confidence: 99%

Naringin Reveals Ameliorative Property Over Elevated Oxidative Stress Levels in Animal Models

Singh¹,

Kaur²,

Sharma³

2018

Asian J Pharm Clin Res

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Oxidative stress (OxiS) has been implicated in the pathogenesis of many diseases. Free radicals interact with different cell components including DNA, proteins, and lipids to become stable. In this process, these free radicals damage the integrity of these biological moieties and result in various health implications. Naringin (NG), a naturally occurring phytochemical commonly found in grapefruit juice has been explored for its protective role against OxiS. In this short review paper, an attempt has been made to compile the study reports revealing the antioxidative nature of NG in different animal models. Studies have reported NG as a potential antioxidant in various health ailments including diabetes, cardiac fibrosis, cognitive dysfunction, and neurodegeneration.

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Combination effect naringin and pravastatin in lipid profile and glucose in obese rats

Cited by 11 publications

References 21 publications

Effects of naringin and valproate interaction on liver steatosis and dyslipidaemia parameters in male C57BL6 mice

Effects of naringin and valproate interaction on liver steatosis and dyslipidaemia parameters in male C57BL6 mice

Naringin Attenuates High Fat Diet Induced Non-alcoholic Fatty Liver Disease and Gut Bacterial Dysbiosis in Mice

Naringin Reveals Ameliorative Property Over Elevated Oxidative Stress Levels in Animal Models

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