Combination effects of cosmetic moisturisers in the topical treatment of acne vulgaris

Abstract

Cosmetic moisturisers were applied to one side of the face of 18 male Japanese patients with acne vulgaris who were treated with a topical administration of adapalene and clindamycin phosphate gels. We assessed the alleviating effect of the moisturisers on the side effects of the treatment. The severity of acne and the number of inflammatory and non-inflammatory lesions were measured at 0, 2, and 4 weeks. The water content in the stratum corneum and transepidermal water loss were measured by comparing the moisturiser-treated and untreated sides of the face. The sensation of skin dryness and irritation on both sides of the face were assessed by the subjects. We observed that the use of moisturisers did not impact the efficacy of the standard topical treatment and they significantly improved the water content in the stratum corneum and the sensation of dryness. These results suggested that the use of moisturisers in combination with the standard topical treatment may improve adherence to therapy by alleviating the sensation of dryness.

South‐East Asia study alliance guidelines on the management of acne vulgaris in South‐East Asian patients

“…Moisturizers may be used for dry and irritated skin due to acne treatment and should be water‐based, non‐greasy, non‐comedogenic, non‐acnegenic and hypoallergenic. Moisturizers prevent treatment‐induced dryness and improve local tolerance to topical treatment (level of evidence, 1; strength of recommendation, A) . Moreover, moisturizers do not affect the efficacy of topical acne treatment, while improving stratum corneum water content and reducing the sensation of dryness .…”

“…Moisturizers prevent treatment-induced dryness and improve local tolerance to topical treatment (level of evidence, 1; strength of recommendation, A). 64,65 Moreover, moisturizers do not affect the efficacy of topical acne treatment, while improving stratum corneum water content and reducing the sensation of dryness. 62 These benefits were demonstrated in a study involving adapalene in which patients were randomized to receive either adapalene alone or adapalene in combination with a moisturizer.…”

Effects of Makeup Application on Diverting the Gaze of Others from Areas of Inflammatory Lesions in Patients with Acne Vulgaris

“…The combined use of cosmetic moisturizer is reported to increase treatment adherence [14], and various other therapeutic modifications have been tried. Accordingly, the use of makeup does not appear to hinder acne treatments but actually improves patients' QOL [4].…”

Optimizing the use of topical retinoids in Asian acne patients

“…demonstrated that use of cosmetic moisturizers with adapalene and clindamycin gels significantly reduced the sensation of dryness and increased water content in the stratum corneum. Treatment efficacy was not diminished by use of moisturizers, and the authors recommended use of moisturizer plus topical treatment . In another Japanese study, Hayashi et al .…”

“…There is additional evidence besides the Thai study discussed above supporting the use of moisturizers with topical retinoid therapy in Asian patients. In Japan, Munehiro et al 63 demonstrated that use of cosmetic moisturizers with adapalene and clindamycin gels significantly reduced the sensation of dryness and increased water content in the stratum corneum. Treatment efficacy was not diminished by use of moisturizers, and the authors recommended use of moisturizer plus topical treatment.…”