Combination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice

Masi, Laureane Nunes; Martins, Amanda Roque; Crisma, Amanda Rabello; Amaral, Cátia Lira do; Davanso, Mariana Rodrigues; Serdan, Tamires Duarte Afonso; Sá, Roberta Dourado Cavalcante da Cunha de; Cruz, Maysa Mariana; Alonso-Vale, Maria Isabel Cardoso; Torres, Rosângela Pavan; Mancini‐Filho, Jorge; Pereira, Joice Naiara Bertaglia; Righetti, M.; Liberti, Édson Aparecido; Hirabara, Sandro Massao; Curi, Rui

doi:10.1038/s41598-017-04308-1

Cited by 38 publications

(31 citation statements)

References 63 publications

(54 reference statements)

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“…The HFD group had the same final body weight as the HCD group, despite lower caloric intake. These results are in agreement with other studies indicating that calories in the form of fat favor higher fat deposition compared with a high-carbohydrate diet (8,20).…”

Section: Discussionsupporting

confidence: 93%

“…As described in other reports (8,12,13), we previously demonstrated that a high-carbohydrate diet (HCD) given for 2 months leads to a similar body weight gain compared with a high-fat diet (HFD) in Swiss mice (14,15), allowing the evaluation of diet-induced changes in FA composition and inflammatory markers without the influence of obesity. In these studies, we reported changes in FA composition and inflammatory markers in the liver (14) and brain (15).…”

Section: Introductionmentioning

confidence: 72%

“…Diet-induced obesity promotes insulin resistance (4,5), lipid accumulation (6,7), and inflammation (8,9) in skeletal muscle. The regulation of skeletal muscle FA composition is not fully understood; however, it markedly changes with dietary macronutrient composition.…”

Section: Introductionmentioning

confidence: 99%

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A high-carbohydrate diet induces greater inflammation than a high-fat diet in mouse skeletal muscle

Antunes

Godoy

Almeida-Souza

et al. 2020

Braz J Med Biol Res

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We previously reported that both the high-carbohydrate diet (HCD) and high-fat diet (HFD) given for two months promote lipid deposition and inflammation in the liver and brain of mice. The results obtained indicate a tissue-specific response to both diets. Herein, we compared the effects of HCD and HFD on fatty acid (FA) composition and inflammation in the gastrocnemius muscle. Male Swiss mice were fed with HCD or HFD for 1 or 2 months. Saturated FA (SFA), monounsaturated FA (MUFA), n-3 polyunsaturated FA (n-3 PUFA), and n-6 PUFA were quantified. The activities of stearoyl-CoA desaturase 1 (SCD-1), D-6 desaturase (D6D), elongase 6, and de novo lipogenesis (DNL) were estimated. As for indicators of the inflammatory tissue state, we measured myeloperoxidase (MPO) activity and gene expression of F4/80, tumor necrosis factor-a (TNF-a), interleukin (IL)-4, IL-6, and IL-10. The HCD led to a lower deposition of SFA, MUFA, n-3 PUFA, and n-6 PUFA compared to HFD. However, the HCD increased arachidonic acid levels, SFA/n-3 PUFA ratio, DNL, SCD-1, D6D, and MPO activities, and expression of IL-6, contrasting with the general idea that increased lipid deposition is associated with more intense inflammation. The HCD was more potent to induce skeletal muscle inflammation than the HFD, regardless of the lower lipid accumulation.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 72%

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A high-carbohydrate diet induces greater inflammation than a high-fat diet in mouse skeletal muscle

Antunes

Godoy

Almeida-Souza

et al. 2020

Braz J Med Biol Res

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“…Pekerja beranggapan kental manis merupakan penyumbang kalsium. Berdasarkan penelitian Masi et al (2017) kental manis mengandung lebih tinggi gula dibandingkan dengan kalsium 23 . Selain itu, pekerja bagian perkantoran lebih cenderung berada di dalam ruangan dan sangat sedikit terkena sinar matahari.…”

Section: Hasil Dan Pembahasanunclassified

Hubungan Asupan Zat Gizi Mikro Dan Aktivitas Fisik Dengan Kejadian Obesitas Sentral Pada Pekerja Bagian Perkantoran

Rosa

Riamawati²

2019

AMNT

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Background: Central obesity is a condition where there is a lot of fat accumulating in the body especially around the abdomen. Intake of micronutrients such as calcium and water that are lacking and low physical activity in office workers can cause central obesity.Objectives: This study aims to analyze the relationship between micronutrient intake (calcium and water) and physical activity with central obesity in office workers in PT X, Lamongan.Methods: This study was carried out using a analytic observational method using a cross sectional study design with a quantitative approach. The research sample was 44 office workers in PT X, Lamongan who were taken randomly. Data collected included measurements of waist circumference, measurements of body weight and height, 3x24 hour food recall and physical activity questionnaire. Analysis of the data in this study used a Chi-square test with 95% CI (α = 0.05).Results: This study showed that micronutrient intake consisting of calcium intake (p = 0.486) and water intake (p = 1.000) was not associated with central obesity. Meanwhile, there is a relationship between physical activity and central obesity in office workers (p = 0.028, OR = 5.40).Conclusions: Central obesity in office workers has a relationship with physical activity. However, micronutrient intake (calcium and water) is not associated with central obesity in office workers. Workers should routinely monitor their weight and abdominal circumference together with physical activities such as exercise to prevent central obesity.ABSTRAKLatar Belakang: Obesitas sentral adalah suatu keadaan dimana terdapat banyak lemak yang menumpuk di dalam tubuh khususnya di sekitar perut. Asupan zat gizi mikro seperti kalsium dan air yang kurang serta rendahnya aktivitas fisik pada pekerja bagian perkantoran dapat menyebabkan terjadinya obesitas sentral.Tujuan: Penelitian ini bertujuan untuk menganalisis hubungan antara asupan zat gizi mikro (kalsium da air) dan aktivitas fisik dengan kejadian obesitas sentral pada pekerja bagian perkantoran di PT X, Lamongan.Metode: Penelitian ini dilaksanakan dengan metode observasional analitik menggunakan desain studi cross sectional dengan pendekatan kuantitatif. Sampel penelitian sebesar 44 pekerja bagian perkantoran di PT X, Lamongan yang diambil secara acak. Data yang dikumpulkan meliputi pengukuran lingkar perut, pengukuran berat badan dan tinggi badan, food recall 3x24 jam dan kuesioner aktivitas fisik. Analisa data dalam penelitian ini menggunakan uji Chi-s quare dengan CI sebesar 95% (α = 0.05).Hasil: Penelitian ini menunjukkan bahwa asupan zat gizi mikro yang terdiri dari asupan kalsium (p=0,486) dan asupan air (p=1,000) tidak berhubungan dengan kejadian obesitas sentral. Sementara itu, terdapat hubungan antara aktivitas fisik dengan kejadian obesitas sentral pada pekerja bagian perkantoran (p=0,028, OR=5,40).Kesimpulan: Obesitas sentral pada pekerja bagian perkantoran memiliki hubungan dengan aktivitas fisik. Akan tetapi, asupan zat gizi mikro (kalsium dan air) tidak berhubungan dengan obesitas sentral pada pekerja bagian perkantoran. Pekerja sebaiknya melakukan pemantauan terhadap berat badan dan lingkar perut secara rutin bersamaan dengan melakukan aktivitas fisik seperti berolahraga untuk mencegah terjadinya obesitas sentral.

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“…This suggests an imbalance in the antioxidant defense system in offspring of obese fathers. Inflammation of adipose tissue, a common feature of obesity, has been associated with insulin resistance and an imbalance of the antioxidant defense system (MASI et al, 2017;SURIYAPROM et al, 2019). Both have been implicated in several diseases, such as atherosclerosis, diabetes and obesity (SALTIEL;OLEFSKY, 2017;SURIYAPROM et al, 2019).…”

Section: Programming Effects Of Paternal Obesity In Female Offspring mentioning

confidence: 99%

Influence of paternal consumption of a high-fat/high-sugar diet and/or orange juice during preconception on C57BL/6 female mice offspring breast cancer risk

Silva¹

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SILVA, L. B. A. R. Influence of paternal consumption of a high-fat/high-sugar diet and/or orange juice during preconception on C57BL/6 female mice offspring breast cancer risk. 2019. 90 p. Thesis (PhD)-Faculty of Pharmaceutical Sciences, University of São Paulo. Breast cancer is the most frequent cancer in women worldwide. Paternal consumption of a highfat diet has been shown to program breast cancer risk in female offspring. Orange juice is widely consumed and is known for its content of bioactive compounds that may have a role in regulating epigenetic processes. Therefore, the aim of the present study was to evaluate the effects of paternal obesity and orange juice consumption on female offspring susceptibility to chemically-induced breast carcinogenesis. Three-week-old C57BL/6 male mice were distributed in control (CO), control-orange juice (CJ), obese (OB) and obese-orange juice (OJ) groups, fed either a standard chow or a high-fat/high-sugar diet (45% lard-based diet supplemented with sweetened condensed milk), with water or orange juice, for 11 weeks before mating. Female offspring were weaned onto standard chow until 7 weeks of age and then were initiated with 7,12-dimethyl-benzo[a]anthracene to induce mammary tumors. CJ female offspring presented higher multiplicity of mammary tumors (p£0.05) compared to CO offspring. Female offspring from OB group showed higher tumor latency (p£0.05), lower tumor incidence (p£0.05), higher multiplicity of tumors (p£0.05), lower cell proliferation (Ki67) in the mammary ducts (p£0.05) and lower global levels of H3K27me3 in the mammary gland (p£0.05) when compared to CO offspring. No differences (p³0,05) were observed between OB and OJ female offspring regarding these parameters. Consumption of orange juice by non-obese fathers during preconception increased susceptibility of female offspring to mammary carcinogenesis. Although paternal consumption of a high-fat/high-sugar diet during preconception decreased incidence and increased latency of tumors, the multiplicity of lesions increased. In addition, the data indicates that the response to orange juice consumption depends of the paternal metabolic context.

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Combination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice

Cited by 38 publications

References 63 publications

A high-carbohydrate diet induces greater inflammation than a high-fat diet in mouse skeletal muscle

A high-carbohydrate diet induces greater inflammation than a high-fat diet in mouse skeletal muscle

Hubungan Asupan Zat Gizi Mikro Dan Aktivitas Fisik Dengan Kejadian Obesitas Sentral Pada Pekerja Bagian Perkantoran

Influence of paternal consumption of a high-fat/high-sugar diet and/or orange juice during preconception on C57BL/6 female mice offspring breast cancer risk

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