Combination of a Teratoma and Embryonal Carcinoma of the Testis in SD IGS Rats: A Report of Two Cases

Sawaki, Masakuni; Shinoda, Kazutoshi; Hoshuyama, Satsuki; Kato, Fumie; Yamasaki, Kanji

doi:10.1177/019262330002800611

Cited by 12 publications

(13 citation statements)

References 11 publications

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“…Teratomas are rare tumors in rats and only a few cases of spontaneous teratocarcinogenesis have been reported in testis, adrenal gland, kidney, central nervous system or abdomen [43], [44], [45], [46]. Hereditary teratomas have also been found in testes and ovaries of the Tera strain that was developed from the Csk: Wistar-Imamichi rat [47]; however, the underlying mutation was never identified.…”

Section: Discussionmentioning

confidence: 99%

The ter Mutation in the Rat Dnd1 Gene Initiates Gonadal Teratomas and Infertility in Both Genders

et al. 2012

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A spontaneous mutation leading to the formation of congenital ovarian and testicular tumors was detected in the WKY/Ztm rat strain. The histological evaluation revealed derivatives from all three germ layers, thereby identifying these tumors as teratomas. Teratocarcinogenesis was accompanied by infertility and the underlying mutation was termed ter. Linkage analysis of 58 (WKY-ter×SPRD-Cu3) F2 rats associated the ter mutation with RNO18 (LOD = 3.25). Sequencing of candidate genes detected a point mutation in exon 4 of the dead-end homolog 1 gene (Dnd1), which introduces a premature stop codon assumed to cause a truncation of the Dnd1 protein. Genotyping of the recessive ter mutation revealed a complete penetrance of teratocarcinogenesis and infertility in homozygous ter rats of both genders. Morphologically non-tumorous testes of homozygous ter males were reduced in both size and weight. This testicular malformation was linked to a lack of spermatogenesis using immunohistochemical and histological staining. Our WKY-Dnd1ter/Ztm rat is a novel animal model to investigate gonadal teratocarcinogenesis and the molecular mechanisms involved in germ cell development of both genders.

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Section: Discussionmentioning

confidence: 99%

The ter Mutation in the Rat Dnd1 Gene Initiates Gonadal Teratomas and Infertility in Both Genders

et al. 2012

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“…As far as laboratory rats and mice are concerned, teratocarcinoma of the testis is commonly seen only in mouse strain 129 (Stevens and Little 1954). The few other reports of teratocarcinoma or teratoma in the testis of rats and mice include teratocarcinomas in two SD IGS rats (Sawaki et al 2000), a teratoma in an ICR strain mouse (Tani et al 1997), and teratocarcinomas in a DBA/2J and A/HeJ mouse (Meier et al 1970). A case of spontaneous ovarian teratoma has been reported in a Swiss Albino mouse (Fawcett 1950).…”

Section: Introductionmentioning

confidence: 99%

A Spontaneous Teratocarcinoma in the Testis of a Swiss Albino Mouse

Jamadagni¹,

Jamadagni²,

Upadhyay³

et al. 2011

Toxicol Pathol

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A unilateral non-metastatic embryonal carcinoma and teratoma of the testis was observed in a 12-week-old Swiss Albino mouse at the end of a 28-day repeated dose toxicity study. The teratocarcinoma almost completely replaced the parenchyma of the left testis. The tumor was composed of sheets and rosettes of primitive embryonal cells, anaplastic cells, skeletal muscle tissue, sebaceous gland tissue, keratinized stratified squamous epithelium, and ciliated cuboidal epithelium. The histomorphological characteristics of the tumor were reviewed and presented in this report. To the best of the authors' knowledge, this is the first report of spontaneous teratocarcinoma of testis in the Swiss Albino strain of mice.

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“…82,83,277,286,287 The incidence of testicular tumors is higher in the dog than in many other species. Other tumor types are described but only sporadically or rarely in aged rats and mice.…”

Section: Drug-induced Changesmentioning

confidence: 99%

Male Genital Tract

Greaves

2012

Histopathology of Preclinical Toxicity Studies

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Combination of a Teratoma and Embryonal Carcinoma of the Testis in SD IGS Rats: A Report of Two Cases

Cited by 12 publications

References 11 publications

The ter Mutation in the Rat Dnd1 Gene Initiates Gonadal Teratomas and Infertility in Both Genders

The ter Mutation in the Rat Dnd1 Gene Initiates Gonadal Teratomas and Infertility in Both Genders

A Spontaneous Teratocarcinoma in the Testis of a Swiss Albino Mouse

Male Genital Tract

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