Combination of Acute Physiology and Chronic Health Evaluation II score, early lactate area, and N-terminal prohormone of brain natriuretic peptide levels as a predictor of mortality in geriatric patients with septic shock

Wang, Hao; Li, Zhong; Yin, Ming; Chen, Xiaomei; Ding, Shilei; Li, Chen; Zhai, Qian; Li, Yuan; Liu, Han; Wu, Dawei

doi:10.1016/j.jcrc.2014.11.013

Cited by 19 publications

(24 citation statements)

References 42 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…52,53 Biomarkers including cardiac troponin I and N-terminal pro-brain natriuretic peptide (NT-proBNP) may also have a role in predicting mortality in elders with severe sepsis or septic shock. 54,55 …”

Section: Severe Sepsis and Septic Shockmentioning

confidence: 99%

Sepsis and Other Infectious Disease Emergencies in the Elderly

Liang

2016

Emergency Medicine Clinics of North America

View full text Add to dashboard Cite

Section: Severe Sepsis and Septic Shockmentioning

confidence: 99%

Sepsis and Other Infectious Disease Emergencies in the Elderly

Liang

2016

Emergency Medicine Clinics of North America

View full text Add to dashboard Cite

“…Of the 46 studies included in this review, 35 examined the association of brain natriuretic peptides (BNP, NT‐proBNP) with survival in patients with septic shock, presented in Table . The vast majority were prospective cohort studies.…”

Section: Resultsmentioning

confidence: 99%

“…This association was also evaluated by two studies in the setting of an RCT evaluating the use of 20% human albumin plus crystalloids or crystalloids alone in patients with severe sepsis or septic shock . In total, 30 studies, including the two conducted in the setting of the RCT, have found a significant association between elevated levels of brain natriuretic peptides and increased mortality …”

Section: Resultsmentioning

confidence: 99%

“…The primary outcome of this systematic review was to assess the utility of BNP and NT‐proBNP as prognostic markers in septic shock. Brain natriuretic peptides have been shown to be adequate predictors of mortality in septic shock by numerous studies . However, there are significant differences in the reported limits for an optimal cut‐off value, ranging from 210 to 800 ng/L for BNP, with suboptimal sensitivity and specificity .…”

Section: Discussionmentioning

confidence: 99%

“…24,27 In total, 30 studies, including the two conducted in the setting of the RCT, have found a significant association between elevated levels of brain natriuretic peptides and increased mortality. [14][15][16][17][18]20,21,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37]39,41,42,[45][46][47] Various studies reported the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (PLR), negative likelihood ratio (NLR) of BNP and NT-proBNP in predicting mortality in septic shock. Several cut-off values have been proposed for both markers, 18,25,37,39,41,46,47 with some reporting that low BNP cut-off values (190 ng/L) were associated with a 5.7-fold increased risk of death (95% confidence interval [CI], 1.78-27.48; P < 0.014), 41 whereas others using higher cut-off values (800 ng/L) considered BNP a poor predictor of outcome.…”

Section: Association Of Brain Natriuretic Peptides With Survival Inmentioning

confidence: 99%

See 2 more Smart Citations

The utility of brain natriuretic peptides in septic shock as markers for mortality and cardiac dysfunction: A systematic review

et al. 2019

View full text Add to dashboard Cite

Objective To conduct a systematic review evaluating the utility of brain natriuretic peptide (BNP) and N‐terminal proBNP (NT‐proBNP) as biomarkers in adult patients with septic shock. Materials and Methods Pubmed/Medline databases were searched from inception to November 2018 using the search terms: (septic[Title/Abstract] AND shock[Title/Abstract]) AND bnp[Title/Abstract]) and (septic[Title/Abstract]) AND shock[Title/Abstract]) AND natriuretic[Title/Abstract]). No restriction was applied regarding date of publication. Comparative observational studies evaluating BNP and NT‐proBNP in patients with septic shock aged ≥18 years were eligible for inclusion. Bibliographies from the extracted articles were also reviewed to identify additional relevant publications. Results In total, 46 studies met all eligibility criteria and were included. A strong body of literature has demonstrated that in patients with septic shock, increased values of BNP and NT‐proBNP are associated with increased mortality. An increase from baseline BNP values has also been associated with increased mortality, whereas decreases from baseline values are not related to worse outcome. Brain natriuretic peptides have also been associated with cardiac dysfunction in patients with sepsis. Moreover, BNP values have been found to be significantly elevated in septic shock, regardless of cardiac dysfunction, and have been used to distinguish between septic and cardiogenic shock. Furthermore, BNP and NT‐proBNP are significantly increased in patients with septic shock, compared to patients with sepsis and severe sepsis. Conclusions BNP and NT‐proBNP appear to be reliable predictors of outcome in septic shock.

show abstract