2016
DOI: 10.1016/j.ejca.2016.03.069
|View full text |Cite
|
Sign up to set email alerts
|

Combination of bendamustine and rituximab as front-line therapy for patients with chronic lymphocytic leukaemia: multicenter, retrospective clinical practice experience with 279 cases outside of controlled clinical trials

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

4
14
1

Year Published

2017
2017
2022
2022

Publication Types

Select...
7

Relationship

2
5

Authors

Journals

citations
Cited by 23 publications
(19 citation statements)
references
References 25 publications
4
14
1
Order By: Relevance
“…The frequencies of hematologic AEs in this study were generally similar to those in previously published reports of CLL treatments, but the frequencies of nonhematologic AEs were generally higher than those in other published studies involving chemoimmunotherapy regimens . The finding that the mean monthly per‐patient costs increased gradually with the number of unique AEs highlights the substantial economic burden associated with toxicities.…”
Section: Discussionsupporting
confidence: 85%
See 1 more Smart Citation
“…The frequencies of hematologic AEs in this study were generally similar to those in previously published reports of CLL treatments, but the frequencies of nonhematologic AEs were generally higher than those in other published studies involving chemoimmunotherapy regimens . The finding that the mean monthly per‐patient costs increased gradually with the number of unique AEs highlights the substantial economic burden associated with toxicities.…”
Section: Discussionsupporting
confidence: 85%
“…21,24 The frequencies of hematologic AEs in this study were generally similar to those in previously published reports of CLL treatments, but the frequencies of nonhematologic AEs were generally higher than those in other published studies involving chemoimmunotherapy regimens. 12,[25][26][27] The finding that the mean monthly per-patient costs increased gradually with the number of unique AEs highlights the substantial economic burden associated with toxicities. Because fewer than only one-third of patients received a CLL-directed treatment during the observation period, it is also likely that the increases in number of AEs and associated costs are correlated with the receipt as well as the nature of CLL-directed therapies.…”
Section: Discussionmentioning
confidence: 99%
“…Our data are in line with those of Goede et al 6 who reported that groups with different PFS could be distinguished in a cohort of elderly unfit CLL patients receiving CLB or CLB plus an anti-CD20 antibody as first-line treatment (CLL11 trial), based upon the CLL-IPI criteria. These findings are also consistent with the observation that TP53 disruption, IGHV unmutated status, or β2M levels, when considered as single parameters, are also associated with treatment outcomes after chemo-immunotherapy [8][9][10][11][12][13][14]. Moreover, when the CLL-IPI was forced in a multivariate modeltogether with the chemo-immunotherapy regimen (FCR/PCR/PCO vs BR), both parameters remained significantly associated with PFS (CLL-IPI, HR 1.58; 95% CI 1.41-1.77, P < 0.0001; FCR-PCR-PCO vs BR, HR 1.31; 95% CI 1.02-1.67, P = 0.033), showing that the CLL-IPI score allows of predicting the risk of progression regardless of the different chemo-immunotherapy approach.…”
supporting
confidence: 90%
“…Bendamustine is commonly used with rituximab and has good response rates in treatment-naive patients without del(17p) 137 , although no randomized trials comparing bendamustine and rituximab versus bendamustine alone have been conducted. Bendamustine has also been used in combination with obinutuzumab, which showed highly encouraging results 138 and is being evaluated in larger clinical trials.…”
Section: Managementmentioning
confidence: 99%