2018
DOI: 10.14499/indonesianjcanchemoprev9iss1pp9-15
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Combination of Curcuma (Curcuma xanthorriza Roxb) and Awar-awar (Ficus septica Burm.F.) Ethanolic Extracts Enhance Doxorubicin to Modulate Cell Cycle Progression of T47D Cells

Abstract: One of the efforts to cure breast cancer is a combination of the chemotherapeutic agent with medicinal plants. This study was conducted to examine the activity of the combination between doxorubicin, curcuma rhizome (Curcuma xanthorriza Roxb.) ethanolic extract (CEE), and awar-awar leaves (Ficus septica Burm.f.) ethanolic extract (AAE) in inducing apoptosis and modulating the cell cycle progression in breast cancer T47D cells. The combination activity was performed using three series of concentration, 1/3; 1/6… Show more

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“…Pada sel T47D, ekstrak etanolik daun awar-awar (EEDAA) memberikan efek sitotoksik dengan nilai IC50 sebesar 13 µg/mL (Pratama et al, 2011). Kombinasinya dengan ekstrak termulawak menunjukkan efek sinergis terhadap peningkatan sitotoksisitas agen kemoterapi doksorubisin dan sisplatin (Hidayati et al, 2017;Muna & Jenie, 2018;Nugroho et al, 2013).…”
Section: Sitotoksisitas Daun Awar-awar Pada Berbagai Jenis Kankerunclassified
“…Pada sel T47D, ekstrak etanolik daun awar-awar (EEDAA) memberikan efek sitotoksik dengan nilai IC50 sebesar 13 µg/mL (Pratama et al, 2011). Kombinasinya dengan ekstrak termulawak menunjukkan efek sinergis terhadap peningkatan sitotoksisitas agen kemoterapi doksorubisin dan sisplatin (Hidayati et al, 2017;Muna & Jenie, 2018;Nugroho et al, 2013).…”
Section: Sitotoksisitas Daun Awar-awar Pada Berbagai Jenis Kankerunclassified