Combination of dexamethasone and local anaesthetic solution in peripheral nerve blocks

Abstract

Combining dexamethasone with local anaesthetics results in a prolongation of the duration of peripheral nerve block.

Analysis of efficacy of adding dexamethasone to ropivacaine in oral surgery

“…Considering the fact that there is no available information in the literature about perineural application (n.alveolaris inferior and rr.alveolares superiors posteriores) of ropivacaine in combination with dexamethasone in oral surgery, and that the combination dosage used in the study (4ml 0.75 % anesthesia and 1ml / 4mg Dexamethasone) was lower than the combination listed in the existing literature, our results show that this combination is equally successful in achieving perioperative and postoperative anesthesia in oral surgery as in other surgical branches [38][39] .…”

“…alveolares superiors posteriores) i deksametazona u oralnoj hirurgiji, kao i da smo u studiji upotrebili manje doze ove kombinacije od 4 ml 0,75% anestetika i 1 ml/4 mg deksametazona, nego one koje su navedene u literaturi, naši rezultati pokazuju da je ova kombinacija jednako uspešna za postizanje perioperativne i postoperativne anestezije kao i u drugim hirurškim granama [38][39] .…”

“…The anti-inflammatory effect comes from its action on various cells involved in the inflammatory process which decreases the number of T lymphocytes, as well as the phagocytic activity of macrophages, and reduces the release of the inflammatory mediators from macrophages and Tlymphocytes 16 . Numerous studies from different surgical branches show longer absence of pain after surgical intervention when ropivacaine is used with dexamethasone than when it is used alone [17][18][19][20] . To the best of our knowledge, there is no available data about using ropivacaine with dexamethasone in oral surgery.…”

“…Antiinflamatorni efekat je posledica dejstva na različite ćelije koje su uključene u inflamatorni proces, jer glukokortikoidi dovode do smanjenja broja T limfocita, smanjenja fagocitne aktivnosti makrofaga i oslobađanja medijatora inflamacije iz makrofaga i T-limfocita 16 . Brojne studije iz različitih hirurških grana upućuju na duži bezbolni period posle hirurške intervencije pri upotrebi ropivakaina sa deksametazonom nego samog ropivakaina [17][18][19][20] . U nama dostupnoj literaturi nema podataka o upotrebi kombinacije ropivakaina sa deksametazonom u oralnoj hirurgiji, Cilj rada bio je da se utvrdi kakav efekat na dužinu trajanja lokalne anestezije ima kombinacija 0,75% ropivakaina sa dodatkom dexametazona u toku oralnohirurških operacija.…”

Continuous Perineural Catheters for Postoperative Pain From an Ambulatory Surgery Center

“…In addition, no additives consistently and predictably prolong a single-injection nerve block beyond 24 hours, unlike a peripheral nerve catheter, which can be used for 3 or more days. 3 Single-injection nerve blocks can be a successful strategy for patient care if they are used with a coordinated perioperative oral analgesic strategy. However, if the goal is optimal pain control, high patient satisfaction, and reduced unplanned physician visits, continuous perineural infusions may be the superior choice.…”