Combination of drug and stem cells neurotherapy: Potential interventions in neurotrauma and traumatic brain injury

Zibara, Kazem; Ballout, Nissrine; Mondello, Stefania; Karnib, Nabil; Ramadan, Naify; Omais, Saad; Nabbouh, Ali; Caliz, Daniela; Clavijo, Angélica; Hu, Zhen; Ghanem, Noël; Gajavelli, Shyam; Kobeissy, Firas

doi:10.1016/j.neuropharm.2018.09.032

Cited by 43 publications

(36 citation statements)

References 306 publications

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“…A range of human stem cell‐based therapy methods have been developed for clinical applications in the treatment of ischemic stroke and CNS injury . Several noninvasive methods are safe for evaluation of cell‐tracking.…”

Section: Discussionmentioning

confidence: 99%

“…33,49,50 In order to validate the clinical application of [ 18 A range of human stem cell-based therapy methods have been developed for clinical applications in the treatment of ischemic stroke and CNS injury. [51][52][53] Several noninvasive methods are safe for evaluation of cell-tracking. MRI, as a representative imaging modality, provides anatomical details of target organs with a high level of clinical accessibility.…”

Section: [ 18 F] Fedacmentioning

confidence: 99%

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In vivo monitoring of remnant undifferentiated neural cells following human induced pluripotent stem cell-derived neural stem/progenitor cells transplantation

Tanimoto

Yamasaki

Nagoshi

et al. 2020

Stem Cells Translational Medicine

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Transplantation of human‐induced pluripotent stem cell‐derived neural stem/progenitor cells (hiPSC‐NS/PCs) is a promising treatment for a variety of neuropathological conditions. Although previous reports have indicated the effectiveness of hiPSC‐NS/PCs transplantation into the injured spinal cord of rodents and nonhuman primates, long‐term observation of hiPSC‐NS/PCs post‐transplantation suggested some “unsafe” differentiation‐resistant properties, resulting in disordered overgrowth. These findings suggest that, even if “safe” NS/PCs are transplanted into the human central nervous system (CNS), the dynamics of cellular differentiation of stem cells should be noninvasively tracked to ensure safety. Positron emission tomography (PET) provides molecular‐functional information and helps to detect specific disease conditions. The current study was conducted to visualize Nestin (an NS/PC marker)‐positive undifferentiated neural cells in the CNS of immune‐deficient (nonobese diabetic‐severe combined immune‐deficient) mice after hiPSC‐NS/PCs transplantation with PET, using 18 kDa translocator protein (TSPO) ligands as labels. TSPO was recently found to be expressed in rodent NS/PCs, and its expression decreased with the progression of neuronal differentiation. We hypothesized that TSPO would also be present in hiPSC‐NS/PCs and expressed strongly in residual immature neural cells after transplantation. The results showed high levels of TSPO expression in immature hiPSC‐NS/PCs‐derived cells, and decreased TSPO expression as neural differentiation progressed in vitro. Furthermore, PET with [18F] FEDAC (a TSPO radioligand) was able to visualize the remnant undifferentiated hiPSC‐NS/PCs‐derived cells consisting of TSPO and Nestin+ cells in vivo. These findings suggest that PET with [18F] FEDAC could play a key role in the safe clinical application of CNS repair in regenerative medicine.

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Section: Discussionmentioning

confidence: 99%

Section: [ 18 F] Fedacmentioning

confidence: 99%

In vivo monitoring of remnant undifferentiated neural cells following human induced pluripotent stem cell-derived neural stem/progenitor cells transplantation

Tanimoto

Yamasaki

Nagoshi

et al. 2020

Stem Cells Translational Medicine

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“…The early injury resulting from an external force creates brain tissue destruction with parenchymal impairment, intracerebral hemorrhage, and axonal cutting. Likewise, the primary insult provokes secondary neurometabolic and neurochemical events, including inflammation, cerebral edema, disruption of the blood-brain barrier (BBB), oxidative stress, excitotoxicity, and mitochondrial and metabolic dysfunctions, that can extremely modify the outcome and the recovery patterns, persisting for months to years post-injury [3]. While animal models do not replicate all the physiological, anatomical, and neurobehavioral qualities of human TBI, they do provide important insight into pathophysiological mechanisms and provide the opportunity for translational research and development of efficacious neurotherapeutic interventions [3].…”

Section: Introductionmentioning

confidence: 99%

“…Likewise, the primary insult provokes secondary neurometabolic and neurochemical events, including inflammation, cerebral edema, disruption of the blood-brain barrier (BBB), oxidative stress, excitotoxicity, and mitochondrial and metabolic dysfunctions, that can extremely modify the outcome and the recovery patterns, persisting for months to years post-injury [3]. While animal models do not replicate all the physiological, anatomical, and neurobehavioral qualities of human TBI, they do provide important insight into pathophysiological mechanisms and provide the opportunity for translational research and development of efficacious neurotherapeutic interventions [3]. Animal TBI models can be catalogued as penetrating or non-penetrating with the principal difference being the occurrence of a direct deformation of the brain in penetrating injuries, thus provoking a focal or diffused damage at the injury site.…”

Section: Introductionmentioning

confidence: 99%

Management of Traumatic Brain Injury: From Present to Future

et al. 2020

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TBI (traumatic brain injury) is a major cause of death among youth in industrialized societies. Brain damage following traumatic injury is a result of direct and indirect mechanisms; indirect or secondary injury involves the initiation of an acute inflammatory response, including the breakdown of the blood–brain barrier (BBB), brain edema, infiltration of peripheral blood cells, and activation of resident immunocompetent cells, as well as the release of numerous immune mediators such as interleukins and chemotactic factors. TBI can cause changes in molecular signaling and cellular functions and structures, in addition to tissue damage, such as hemorrhage, diffuse axonal damages, and contusions. TBI typically disturbs brain functions such as executive actions, cognitive grade, attention, memory data processing, and language abilities. Animal models have been developed to reproduce the different features of human TBI, better understand its pathophysiology, and discover potential new treatments. For many years, the first approach to manage TBI has been treatment of the injured tissue with interventions designed to reduce the complex secondary-injury cascade. Several studies in the literature have stressed the importance of more closely examining injuries, including endothelial, microglia, astroglia, oligodendroglia, and precursor cells. Significant effort has been invested in developing neuroprotective agents. The aim of this work is to review TBI pathophysiology and existing and potential new therapeutic strategies in the management of inflammatory events and behavioral deficits associated with TBI.

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“…Recognizing the critical neuronal loss and wide variability existing in pathophysiologic mechanisms triggered by TBI, the current focus is on the regenerative potential and pleiotropic neuroprotective properties of stem cell therapy for TBI (9,10). Accordingly Sophisticated experiments reinterpreting previous unsuccessful therapeutic interventions (11,12), including erythropoietin (Robinson et al), hypothermia (Szczygielski et al), and selective brain cooling (Leung et al) have also been conducted providing authors with the opportunity to identify potential reasons for clinical failure.…”

mentioning

confidence: 99%

Editorial: Developing Successful Neuroprotective Treatments for TBI: Translational Approaches, Novel Directions, Opportunities and Challenges

2019

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Combination of drug and stem cells neurotherapy: Potential interventions in neurotrauma and traumatic brain injury

Cited by 43 publications

References 306 publications

In vivo monitoring of remnant undifferentiated neural cells following human induced pluripotent stem cell-derived neural stem/progenitor cells transplantation

In vivo monitoring of remnant undifferentiated neural cells following human induced pluripotent stem cell-derived neural stem/progenitor cells transplantation

Management of Traumatic Brain Injury: From Present to Future

Editorial: Developing Successful Neuroprotective Treatments for TBI: Translational Approaches, Novel Directions, Opportunities and Challenges

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