Combination of ECMO and cytokine adsorption therapy for severe sepsis with cardiogenic shock and ARDS due to Panton–Valentine leukocidin—positive Staphylococcus aureus pneumonia and H1N1

Lees, Nicholas J.; Rosenberg, Ajp; Hurtado-Doce, Ana; Jones, Jane; Marczin, N.; Zeriouh, Mohamad; Weymann, Alexander; Sabashnikov, Anton; Simon, A.; Попов, А А

doi:10.1007/s10047-016-0915-8

Cited by 38 publications

(31 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These findings are in line with two published case reports on the use of CytoSorb in patients with toxic shock syndrome showing the potential role of this therapy in stabilizing hemodynamics, decreasing vasopressor requirements, improving lactate clearance, and reducing erythema as short term effects [ 2 , 3 ].…”

Section: Discussionsupporting

confidence: 87%

Use of Hemadsorption in a Case of Pediatric Toxic Shock Syndrome

Berkes

Szikszay

Kappelmayer

et al. 2017

Case Reports in Critical Care

View full text Add to dashboard Cite

Background Toxic shock syndrome is a potentially fatal toxin-mediated disease. The role of toxins in this clinical entity made us hypothesize that extracorporeal blood purification with CytoSorb® could play a beneficial role in the clinical management of toxic shock syndrome. This case report describes the successful treatment of toxic shock syndrome using a combination of renal replacement therapy and hemadsorption in a pediatric patient. Case Presentation A 5-year-old girl with Down's syndrome presented with an inflamed area surrounding an insect bite, signs of systemic inflammation, and multiple organ failure. As previous attempts of immune modulation therapy were unsuccessful, renal replacement therapy was supplemented by the cytokine absorber CytoSorb. Treatment using this combination was associated with a rapid and significant stabilization in the hemodynamic situation and a decrease in inflammatory mediators within hours after the initiation of therapy. The application of CytoSorb therapy was simple and safe. Conclusion The use of extracorporeal blood purification with CytoSorb proved potentially beneficial by removing toxins and inflammatory mediators in this case and could therefore play a role in the clinical management of toxic shock syndrome. Whether CytoSorb has the potential to even positively influence mortality in patients with toxic shock syndrome still needs to be confirmed.

show abstract

Section: Discussionsupporting

confidence: 87%

Use of Hemadsorption in a Case of Pediatric Toxic Shock Syndrome

Berkes

Szikszay

Kappelmayer

et al. 2017

Case Reports in Critical Care

View full text Add to dashboard Cite

show abstract

“…However, study on the usage of this drug to treat hyper upregulation of IL-6 due to severe IAV infection has yet to be conducted. On the other hand, in a case of H1N1 virus-induced ARDS, the use of an extracorporeal cytokine hemoadsorption device to remove cytokines including TNF and IL-6 from the bloodstream ( 212 ) has showed beneficial to the patient ( 213 ). More research is required to confirm whether the removal or neutralization of IL-6 could be a potential therapy for severe IAV infections.…”

Section: Regulation Of Aberrant Immune Responses In Iav Infectionmentioning

confidence: 99%

Advancements in Host-Based Interventions for Influenza Treatment

et al. 2018

View full text Add to dashboard Cite

Influenza is a major acute respiratory infection that causes mortality and morbidity worldwide. Two classes of conventional antivirals, M2 ion channel blockers and neuraminidase inhibitors, are mainstays in managing influenza disease to lessen symptoms while minimizing hospitalization and death in patients with severe influenza. However, the development of viral resistance to both drug classes has become a major public health concern. Vaccines are prophylaxis mainstays but are limited in efficacy due to the difficulty in matching predicted dominant viral strains to circulating strains. As such, other potential interventions are being explored. Since viruses rely on host cellular functions to replicate, recent therapeutic developments focus on targeting host factors involved in virus replication. Besides controlling virus replication, potential targets for drug development include controlling virus-induced host immune responses such as the recently suggested involvement of innate lymphoid cells and NADPH oxidases in influenza virus pathogenesis and immune cell metabolism. In this review, we will discuss the advancements in novel host-based interventions for treating influenza disease.

show abstract

“…Invasion, persistence and colonization of foreign microbiota challenge the host immune system to further provoke ARDS; the proliferation of microbiota and heightened responses to challenge further provoke the accumulated lung injury to develop into sepsis ( 34 ). Infections with and the persistence of numerous viral strains and microbiota, including influenza A ( 35 ), Mycobacterium tuberculosis ( 36 ), Staphylococcus aureus /H1N1 strain of the influenza virus ( 37 ) and multi-drug resistant Acinetobacter baumannii ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

Messenger RNA sequencing reveals similar mechanisms between neonatal and acute respiratory distress syndrome

et al. 2017

View full text Add to dashboard Cite

Hypoxemia and hypercarbia resulting from a lack of surfactant is considered to be the primary mechanism underlying neonatal respiratory distress syndrome (NRDS). Surfactant replacement therapy may mitigate the symptoms of the disease by decreasing the surface tension of alveoli and facilitating inflation. However, surfactant serves an additional role in immunological processes. Therefore, it may be hypothesized that mechanisms of NRDS involving surfactant exert additional functions to promoting alveolar inflation. Using peripheral blood obtained from mature infants with and without NRDS, in tandem with mRNA sequencing (mRNA-seq) analysis, the present study identified that, while cell cycle regulation and alveolar surfactants serve a role in deterring the further onset of NRDS, innate and pathogen-induced responses of the immune system are among the most important factors in the pathology. The present study illustrated the regulatory importance of these immune pathways in response to alterations in the expression of gene families, particularly in perpetual lung injury leading to NRDS. Notably, data collected from the mRNA-seq analysis revealed similar mechanisms between NRDS and acute respiratory distress syndrome, a clinical phenotype precipitated by the manifestation of a severe form of lung injury due to numerous lung insults, implying that similar therapies may be applied to treat these two diseases.

show abstract

Combination of ECMO and cytokine adsorption therapy for severe sepsis with cardiogenic shock and ARDS due to Panton–Valentine leukocidin—positive Staphylococcus aureus pneumonia and H1N1

Cited by 38 publications

References 14 publications

Use of Hemadsorption in a Case of Pediatric Toxic Shock Syndrome

Use of Hemadsorption in a Case of Pediatric Toxic Shock Syndrome

Advancements in Host-Based Interventions for Influenza Treatment

Messenger RNA sequencing reveals similar mechanisms between neonatal and acute respiratory distress syndrome

Contact Info

Product

Resources

About