Combination of Fospeg-IPDT and a natural antioxidant compound prevents photosensitivity in a murine prostate cancer tumour model

Petri, Aspasia; Alexandratou, Eleni; Kyriazi, Maria; Rallis, Michail; Roussis, Vassilios; Yova, Dido

doi:10.1016/j.pdpdt.2011.11.002

Cited by 9 publications

(11 citation statements)

References 41 publications

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“…This could be due to the potent antioxidant activity of Pinus halepensis bark extract. Previous studies have shown that bark extracts from pinus could protect skin from ROS generated from UV light, chemicals and smoke [31]- [33].…”

Section: Discussionmentioning

confidence: 99%

Effect of Cigarette Smoke on Diabetic Skin and Protection with Topical Administration of Pinus halepensis Extract

Zoumpliou¹,

Stamatiadi²,

Vassiliadis³

et al. 2014

AJPS

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Compared to normal, diabetic skin is characterized by great sensitivity. Oxidative stress is directly involved, contributing to accelerated skin aging, xerodermia and poor wound healing. In the last 10 years, cigarette smoke (CS) exposure has been associated with several skin and dermatological conditions and is directly related to the oxidative stress affecting the skin. However, limited data exist concerning the effect of CS on diabetic skin. Some of the effects of cigarette smoke exposure on the skin of hairless diabetic mice were hereby studied and the potential skin protection by topical applications of Pinus halepensis bark extract was investigated. Female hairless SKH-2 diabetic mice were exposed for 8 days to tobacco smoke and topical applications were performed twice daily. Biophysical parameters such as transepidermal water loss (TEWL), skin elasticity and erythema were measured. In addition, the oxidative stress was evaluated. The results show that diabetes and CS have a synergistic negative action on skin condition, with the development of xerosis and high ROS levels whilst topical applications of Pinus halepensis bark extract protect efficiently the toxic effect of CS on skin, by decreasing skin dryness, oxidative stress and blood glucose levels.

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Section: Discussionmentioning

confidence: 99%

Effect of Cigarette Smoke on Diabetic Skin and Protection with Topical Administration of Pinus halepensis Extract

Zoumpliou¹,

Stamatiadi²,

Vassiliadis³

et al. 2014

AJPS

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“…Resveratrol, genistein, and epigallocatechin‐3‐gallate attenuated apoptosis of haematopoietic cells via reducing DNA damage (Alotaibi, Bhatnagar, Najafzadeh, Gupta, & Anderson, ; Olas & Wachowicz, ; Sonaa, Usha, & Ja In, ). Again, in photodynamic therapy research, Pinus halepensis bark extract prevented the photosensitivity in SCID mice model (Petri et al, ). Coniferyl aldehyde, found in wine, reduced radiation damage via phosphorylation of HSF‐1 and further increased the activation of ERK1/2 (S. Y. Kim, Lee, Nam, Seo, & Lee, ).…”

Section: Herbal Compounds With the Potential To Synergize With Antitumentioning

confidence: 99%

Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence

Lin

Hsu

Tsai

et al. 2019

British J Pharmacology

289

175

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Traditional chemotherapy is being considered due to hindrances caused by systemic toxicity. Currently, the administration of multiple chemotherapeutic drugs with different biochemical/molecular targets, known as combination chemotherapy, has attained numerous benefits like efficacy enhancement and amelioration of adverse effects that has been broadly applied to various cancer types. Additionally, seeking natural‐based alternatives with less toxicity has become more important. Experimental evidence suggests that herbal extracts such as Solanum nigrum and Claviceps purpurea and isolated herbal compounds (e.g., curcumin, resveratrol, and matairesinol) combined with antitumoral drugs have the potential to attenuate resistance against cancer therapy and to exert chemoprotective actions. Plant products are not free of risks: Herb adverse effects, including herb–drug interactions, should be carefully considered. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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“…Particular efforts have been made to address the negative effects of CS either on reducing or even eliminating the oxidative stress. In this context, Pinus halepensis bark extract has been used, which showed significant antioxidant and anti-inflammatory properties upon tobacco smoke, UV or X-rays irradiation of mouse skin, in vivo (27)(28)(29)37). Herein, our observations indicated that Pinus halepensis bark extract was able to protect primary mice keratinocytes from the effects of CS on both viability and oxidative stress, compared to other antioxidants or to the control (non treated) group.…”

Section: Discussionmentioning

confidence: 72%

“…Among them, Pinus halepensis, also known as Aleppo pine, is a Mediterranean pine with a bark extract rich in phenolic antioxidants, such as procyanidins and phenolic acids, which appears to effectively protect against skin inflammation induced by Xrays and UV radiation, in vivo (27,28). Moreover, Pinus maritima bark extract has been shown to protect skin against tobacco smoke and UV radiation (29)(30)(31).…”

mentioning

confidence: 99%

Protective Effects of Pinus halepensis Bark Extract and Nicotine on Cigarette Smoke-induced Oxidative Stress in Keratinocytes

Pavlou

Antoniadou

Peraki

et al. 2020

In Vivo

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Background/Aim: Cigarette smoke (CS) is a major environmental health threat. The oxidative stress induced by CS on keratinocytes and the possible protective effect of nicotine, its receptor inhibitors, and Pinus halepensis bark extract in relation to known antioxidants were investigated. Materials and Methods: Primary mouse keratinocytes were exposed to cigarette smoke in the presence and absence of Pinus halepensis bark extract (1 μg/ml), rutin (50 μΜ) and ascorbic acid (250 μΜ), nicotine (1 μM) with or without mecamylamine (5 μM) and α-bungarotoxin (0.1 μΜ). Keratinocyte viability and oxidative stress were evaluated by MTT and fluorescence assays. Results: Pinus halepensis bark extract decreased the oxidative stress and increased the viability of keratinocytes, and moreover, these effects were more pronounced compared to the mixture of rutin and Lascorbic acid. Nicotine significantly enhanced the viability potentiation of the beneficial effect induced by Pinus halepensis bark extract. Mecamylamine and α-bungarotoxin showed no specific effect. Conclusion: Pinus halepensis bark extract in combination with nicotine may successfully reverse skin damage induced by cigarette smoke. Cigarette smoke (CS) is a global problem of our society and according to the World Health Organization "the tobacco epidemic is one of the biggest public health threats the world has ever faced, killing more than 8 million people a year" (1). The Lancet Commission on pollution and health characterized CS as more dangerous than AIDS, tuberculosis, and malaria (2). CS is associated with cardiovascular diseases, higher risk of skin diseases, such as squamous cell carcinoma and atopic dermatitis, and is connected with decreased wound healing rate (3-7). The skin is the most important target for the harmful effect of CS pollution. Both solid and gas products of CS contain aniline, N-nitrosodimethylamine, benzopyrenes, acrolein, formaldehyde, N-nitrosopyrrolidine that are considered to be toxic, causing serious oxidative damage (8). CS produces reactive oxygen and nitrogen species oxidizing important biomolecules such as DNA, proteins and lipids leading to tissue injury which is translated to enhanced inflammatory phenomena (9-14). One of the main constituents of CS is nicotine; it is an agonist of acetylcholine and acts on the epidermis via the keratinocyte nicotinic acetylcholine receptors (nAChRs) (15). nAChRs are large (290 kDa) pentameric transmembrane complexes, which are ligand-gated ion channels (LGICs) permeable to Na, K and Ca ions (16, 17). Nicotine activity is doubtful as it has been shown to exert both toxic and beneficial effects; it has been reported as neurotoxic and neuroprotectant (18), toxic to muscles and lung epithelium (19, 20), beneficial in colitis (21), while its potential activity on mitochondria apparently requires further investigation (22). Concerning inflammatory and wound healing processes, the effect of nicotine is considered rather negative, while topical nAchR antagonists have been shown to improve these negativ...

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Combination of Fospeg-IPDT and a natural antioxidant compound prevents photosensitivity in a murine prostate cancer tumour model

Cited by 9 publications

References 41 publications

Effect of Cigarette Smoke on Diabetic Skin and Protection with Topical Administration of Pinus halepensis Extract

Effect of Cigarette Smoke on Diabetic Skin and Protection with Topical Administration of Pinus halepensis Extract

Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence

Protective Effects of Pinus halepensis Bark Extract and Nicotine on Cigarette Smoke-induced Oxidative Stress in Keratinocytes

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