Combination of Geriatric Nutritional Risk Index and Carcinoembryonic Antigen to Predict the Survival of Patients With Colorectal Cancer

Xie, Hailun; Wei, Lishuang; Yuan, Guanghui; Liu, Mingxiang; Liang, Yanren; Gao, Shunhui; Wang, Qiwen; Lin, Xin; Tang, Shaohui; Gan, Jialiang

doi:10.3389/fnut.2022.902080

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…The NRI, which combines BMI and ALB levels, has become a widely used nutritional evaluation indicator due to its simplicity and interpretability. NRI not only serves as a nutritional screening tool but has also been proven to be an independent prognostic factor for various types of cancer [14,31]. In the field of PCa, several studies have pointed out that poor nutritional status, as indicated by an NRI < 92, was an independent prognostic factor for overall survival in patients with both metastatic hormone-naive prostate cancer (mHNPC) and metastatic castration-resistant prostate cancer (mCRPC) [22,23].…”

Section: Discussionmentioning

confidence: 99%

Development and Validation of Nomograms Based on Nutritional Risk Index for Predicting Extracapsular Extension and Seminal Vesicle Invasion in Patients Undergoing Radical Prostatectomy

Liu,

Li,

et al. 2023

World J Oncol

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Background:The aim of the study was to investigate the predictive value of the nutritional risk index (NRI) for extracapsular extension (ECE) and seminal vesicle invasion (SVI) in prostate cancer (PCa) patients undergoing radical prostatectomy (RP), and further develop and validate predictive nomograms for ECE and SVI based on the NRI. Methods:We retrospectively analyzed 734 PCa patients who underwent RP between 2010 and 2020 in the Department of Urology at Peking University Third Hospital. The enrolled patients were randomly divided into a primary cohort (n = 489) and a validation cohort (n = 245) in a 2:1 manner. The baseline NRI of patients was calculated using serum albumin level and body mass index, and a malnutrition status was defined as NRI ≤ 98. Univariate and multivariate logistic regression analyses were conducted to identify predictors for ECE and SVI. Nomograms for predicting ECE and SVI were established based on the results of the multivariate logistic regression analysis. The performance of the nomograms was estimated using Harrell's concordance index (C-index), the area under curve (AUC) of receiver operating characteristic (ROC) curves and the calibration curves.Results: In the primary cohort, 70 (14.3%) patients with NRI ≤ 98 were classified as malnutrition, while the remaining 419 (85.7%) patients with NRI > 98 were considered to have normal nutrition. The nomograms for predicting ECE and SVI shared common factors including NRI, percentage of positive biopsy cores (PPC) and biopsy Gleason score, while prostate-specific antigen (PSA) levels and PSA density (PSAD) were only incorporated in ECE nomogram. The C-indexes of the nomograms for predicting ECE and SVI were 0.785 (95% confidence interval (CI): 0.745 -0.826) and 0.852 (95% CI: 0.806 -0.898), respectively. The calibration curves demonstrated excellent agreement between the predictions by the nomograms and the actual observations. The results remained reproducible when the nomograms were applied to the validation cohort. Conclusions:The NRI is significantly associated with ECE and SVI in PCa patients. The nomogram established based on the NRI in our study can provide individualized risk estimation for ECE and SVI in PCa patients, and may be valuable for clinicians in making well-informed decisions regarding treatment strategies and patient management.

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Section: Discussionmentioning

confidence: 99%

Development and Validation of Nomograms Based on Nutritional Risk Index for Predicting Extracapsular Extension and Seminal Vesicle Invasion in Patients Undergoing Radical Prostatectomy

Liu,

Li,

et al. 2023

World J Oncol

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Development and validation of a nomogram based on geriatric nutritional risk index for predicting prognosis and postoperative complications in surgical patients with upper urinary tract urothelial carcinoma

Wu,

Liu,

Wang

et al. 2023

J Cancer Res Clin Oncol

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A combined nutritional risk index and carcinoembryonic antigen score predicts the outcome in radically resected colorectal cancer

Chen,

Xie,

et al. 2024

ANZ Journal of Surgery

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BackgroundNutritional risk index (NRI) and carcinoembryonic antigen (CEA) are useful prognostic markers in colorectal cancer (CRC); however, the prognostic value of a combination of the NRI and CEA, namely, the NRI and CEA score (NCS), needs further investigation.MethodsStage I‐III CRC patients were collected and then divided into three subgroups by counting the NCS: NCS 1: high NRI with normal CEA; NCS 2: high NRI with elevated CEA or low NRI with normal CEA; and NCS 3: low NRI with elevated CEA. The differences in outcome, counted as disease‐free survival (DFS) and overall survival (OS), were tested among the subgroups.ResultsA total of 285 patients were enrolled, with 108 in NCS 1, 118 in NCS 2 and 59 in NCS 3. Patient features, including age, tumour deposit, T stage, N stage and TNM stage, were significantly different in the NCS subgroups. Both the DFS (log‐rank = 26.06, P<0.001) and OS (log‐rank = 39.10, P<0.001) were significant in different NCS subgroups, even in maximum tumour diameter ≤4 cm cases (DFS: log‐rank = 21.42, P<0.001; OS: log‐rank = 30.95, P<0.001), and NCS 1 patients displayed the best outcome compared with the rest of the subgroups. NCS was also found to be an independent risk factor for both DFS and OS.ConclusionsNCS was a useful prognostic indicator in stages I–III CRC patients.

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Combination of Geriatric Nutritional Risk Index and Carcinoembryonic Antigen to Predict the Survival of Patients With Colorectal Cancer

Cited by 3 publications

References 36 publications

Development and Validation of Nomograms Based on Nutritional Risk Index for Predicting Extracapsular Extension and Seminal Vesicle Invasion in Patients Undergoing Radical Prostatectomy

Development and Validation of Nomograms Based on Nutritional Risk Index for Predicting Extracapsular Extension and Seminal Vesicle Invasion in Patients Undergoing Radical Prostatectomy

Development and validation of a nomogram based on geriatric nutritional risk index for predicting prognosis and postoperative complications in surgical patients with upper urinary tract urothelial carcinoma

A combined nutritional risk index and carcinoembryonic antigen score predicts the outcome in radically resected colorectal cancer

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