Combination of homogenous liquid–liquid extraction and dispersive liquid–liquid microextraction for extraction and preconcentration of amantadine from biological samples followed by its indirect determination by flame atomic absorption spectrometry

Sorouraddin, Saeed Mohammad; Farajzadeh, Mir Ali; Hassanyani, A.; Mogaddam, Mohammad Reza Afshar

doi:10.1039/c6ra16572a

Cited by 51 publications

(7 citation statements)

References 39 publications

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“…Among the transition-metal ions, zinc is the second most abundant metal, after iron, in the human body. It also plays a vital role in DNA synthesis, neural signal transmission, gene transcription, and apoptosis. − Moreover, Zn 2+ disorder usually leads to severe diseases, such as metabolic disorder, Alzheimer disease, cerebral ischemia, infantile diarrhea, and epilepsy. − Therefore, to detect the Zn 2+ present in biological and environmental samples, diverse tactics have been proposed, such as electrochemistry, ion selective membrane, inductively coupled plasma mass spectroscopy (ICP-MS), inductively coupled plasma-atomic emission spectrometry (ICP-AES), and atomic absorption spectrometry (AAS). − However, these techniques are limited in real applications due to the cost, sample pretreatment requirement, and time consumption. On the contrary, fluorescent probes toward Zn 2+ detection are rather unique due to their low-cost, high sensitivity, and real-time bioimaging applications. − Thus, the design of such fluorescent probes is still highly anticipated.…”

Section: Introductionmentioning

confidence: 99%

Pyrene-Based AIEE Active Nanoprobe for Zn²⁺ and Tyrosine Detection Demonstrated by DFT, Bioimaging, and Organic Thin-Film Transistor

Shellaiah

Chen

Thirumalaivasan

et al. 2021

ACS Appl. Mater. Interfaces

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The development of aggregation-induced emission enhancement (AIEE) active nanoprobes without any synthetic complication for solution-state and organic thin-film transistor (OTFT)-based sensory applications is still a challenging task. In this study, the novel pyrene-incorporated Schiff base (5-phenyl-4-((pyren-1-ylmethylene)amino)-4H-1,2,4-triazole-3-thiol; PT2) with an AIEE property was synthesized via a one-pot reaction and was reported for detecting Zn 2+ and tyrosine in the solution state and OTFT. In the AIEE studies of PT2 (in CH 3 CN) at various water fractions (f w : 0− 97.5%), the existence of J-aggregation, crystalline changes, and nanofibers formation was confirmed by ultraviolet absorption/photoluminescence (UV/PL) spectroscopy, powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), atomic force microscopy (AFM), and dynamiclight scattering (DLS) techniques. Similarly, PT2-based Zn 2+ detection and sensory reversibility with tyrosine were demonstrated by UV/PL studies with evidence related to crystalline/nanolevel changes in PXRD, SEM, TEM, AFM, and DLS data. Distinct decay profiles associated with the AIEE and sensory responses of PT2 were observed in time-resolved photoluminescence spectra. From the standard deviation and linear fittings of PL titrations, detection limits (LODs) of the Zn 2+ with PT2 and the tyrosine with PT2-Zn 2+ were estimated as 0.79 and 45 nM, respectively. High-resolution mass and 1 H NMR results confirmed 2:1 and 1:1 stoichiometry and binding sites of PT2-Zn 2+ -PT2* and tyrosine-Zn 2+ complexes. Moreover, the values of association constants determined by linear fittings were 4.205 × 10 −7 and 1.73 × 10 −8 M −2 , correspondingly. Optimization via the density functional theory disclosed the binding sites and suppression of twisted intramolecular charge transfer/photoinduced electron transfer (TICT/ PET) as well as the involvement of restricted intramolecular rotation in the AIEE and PET "ON-OFF-ON" mechanisms in the Zn 2+ and tyrosine sensors. Results from the B16−F10 cellular and zebrafish imaging of AIEE, Zn 2+ , and tyrosine sensors further attested the applicability of PT2 in biological samples. Finally, the PT2 and pentacene-incorporated OTFT devices were fabricated. The devices displayed more than 90% change in drain-source current when reacted with Zn 2+ with an LOD of 5.46 μM but showed no response to tyrosine, thereby confirming the reversibility. Moreover, the OTFT devices also demonstrated Zn 2+ ion detection in tap water and lake water samples.

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Section: Introductionmentioning

confidence: 99%

Pyrene-Based AIEE Active Nanoprobe for Zn²⁺ and Tyrosine Detection Demonstrated by DFT, Bioimaging, and Organic Thin-Film Transistor

Shellaiah

Chen

Thirumalaivasan

et al. 2021

ACS Appl. Mater. Interfaces

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“…These droplets have a large surface area, and therefore, a large contact area with the sample solution, which accelerates the extraction balance and increases the enrichment coefficient in trace target analytes. SFOD-LPME has been applied to the extraction and preconcentration of amantadine [25], the extraction of pyrethroid insecticides in fresh fruits and fruit juices [26], the application in determination of some pesticides in milk samples [27], the determination of phenolic endocrine disrupting chemicals in bottled beverages [28], the extraction of carbamate pesticides from fruit juice and vegetable samples [29], the determination of triazole fungicides in water samples [30], and the extraction and depuration of pantoprazole in rat plasma [31].…”

Section: Electronic Supplementary Materialsmentioning

confidence: 99%

Application of solidified floating double-solvent dispersive liquid-phase microextraction for the analysis of the main active components in Zicao Chengqi decoction

Geng

Chen

et al. 2020

SN Appl. Sci.

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A new method was established using solidified floating double-solvent dispersive liquid-phase microextraction combined with high-performance liquid chromatography (HPLC) for the simultaneous determination and extraction of six active ingredients from Aurantii Fructus Immaturus, Magnoliae Officinalis Cortex, Rhei Radix et Rhizoma, and Arnebiae Radix in the Zicao Chengqi decoction. The six active ingredients in Zicao Chengqi decoction include naringenin, honokiol, shikonin, magnolol, emodin, and β,β-dimethylacrylshikonin. In this experiment, the effects of the extractant type and volume, sample phase volume, sample phase pH, extraction time, and stirring speed on the enrichment factor were studied, and optimal extraction conditions were determined. Naringenin (6-600 ng/mL), honokiol (3-219 ng/mL), shikonin (4-350 ng/mL), magnolol (3-230 ng/mL), emodin (3-190 ng/mL), and β,β-dimethylacrylshikonin (3-430 ng/mL) had a good linear relationship and all the correlation coefficients were 0.9900-0.9992. This method was used for the simultaneous concentration and enrichment of the six active ingredients from the Chinese herbal compound, Zicao Chengqi decoction, with recoveries between 95.7 and 100.3%. The results showed that solidified floating double-solvent dispersive liquid-phase microextraction combined with HPLC can be used for the simultaneous extraction and analysis of multiple active components in the Zicao Chengqi decoction.

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“…Due to its inherent benefits, SI-HLLME has established itself as a useful bioanalytical tool. Typical applications of SI-HLLME include the extraction of azole antimicrobial drugs [19], amphetamines [26], fluoroquinolones [27], antiepileptic drugs [28], amantadine [29], etc. It is noteworthy that HLLME is also in good agreement with some principles of green sample preparation (GSP) that promotes the minimization of waste generation and energy demand, the achievement of high sample throughput and the miniaturization and simplification of the analytical procedure [30].…”

Section: Introductionmentioning

confidence: 99%

Salt-Induced Homogeneous Liquid–Liquid Microextraction of Piroxicam and Meloxicam from Human Urine Prior to Their Determination by HPLC-DAD

2022

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A salt-induced homogeneous liquid–liquid microextraction (SI-HLLME) protocol combined with high-performance liquid chromatography–diode array detection is presented for the first time for the determination of piroxicam and meloxicam in human urine. The main parameters affecting the performance of the sample preparation protocol were optimized by means of a two-step experimental design (i.e., 2-level fractional factorial design and Box–Behnken design). Following its optimization, the proposed method was thoroughly validated in terms of the total error concept in order to take into consideration the random and systematic errors. For the target analytes, accuracy profiles were constructed, and they were used as graphical decision-making tools. In all cases, the β-expectation tolerance intervals complied with the acceptance criteria of ±15%, proving that 95% of future results will fall within the defined bias limits. The limits of detection were 0.02 μg mL−1 and 0.03 μg mL−1 for piroxicam and meloxicam, respectively. The relative standard deviations were lower than 4.4% in all cases, and the mean relative biases ranged between −5.7 and 3.4% for both drugs. The proposed scheme is simple and rapid, while it is characterized by high sample throughput. Moreover, SI-HLLME requires reduced sample and reagent consumption, according to the requirements of Green Analytical Chemistry.

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Combination of homogenous liquid–liquid extraction and dispersive liquid–liquid microextraction for extraction and preconcentration of amantadine from biological samples followed by its indirect determination by flame atomic absorption spectrometry

Abstract: A new and simple procedure has been developed for the indirect determination of amantadine in biological samples.

Cited by 51 publications

References 39 publications

Pyrene-Based AIEE Active Nanoprobe for Zn²⁺ and Tyrosine Detection Demonstrated by DFT, Bioimaging, and Organic Thin-Film Transistor

Pyrene-Based AIEE Active Nanoprobe for Zn²⁺ and Tyrosine Detection Demonstrated by DFT, Bioimaging, and Organic Thin-Film Transistor

Application of solidified floating double-solvent dispersive liquid-phase microextraction for the analysis of the main active components in Zicao Chengqi decoction

Salt-Induced Homogeneous Liquid–Liquid Microextraction of Piroxicam and Meloxicam from Human Urine Prior to Their Determination by HPLC-DAD

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Combination of homogenous liquid–liquid extraction and dispersive liquid–liquid microextraction for extraction and preconcentration of amantadine from biological samples followed by its indirect determination by flame atomic absorption spectrometry

Abstract: A new and simple procedure has been developed for the indirect determination of amantadine in biological samples.

Cited by 51 publications

References 39 publications

Pyrene-Based AIEE Active Nanoprobe for Zn2+ and Tyrosine Detection Demonstrated by DFT, Bioimaging, and Organic Thin-Film Transistor

Pyrene-Based AIEE Active Nanoprobe for Zn2+ and Tyrosine Detection Demonstrated by DFT, Bioimaging, and Organic Thin-Film Transistor

Application of solidified floating double-solvent dispersive liquid-phase microextraction for the analysis of the main active components in Zicao Chengqi decoction

Salt-Induced Homogeneous Liquid–Liquid Microextraction of Piroxicam and Meloxicam from Human Urine Prior to Their Determination by HPLC-DAD

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Pyrene-Based AIEE Active Nanoprobe for Zn²⁺ and Tyrosine Detection Demonstrated by DFT, Bioimaging, and Organic Thin-Film Transistor

Pyrene-Based AIEE Active Nanoprobe for Zn²⁺ and Tyrosine Detection Demonstrated by DFT, Bioimaging, and Organic Thin-Film Transistor