Combination of Hyaluronic Acid Hydrogel Scaffold and PLGA Microspheres for Supporting Survival of Neural Stem Cells

Wang, Ying; Wei, Yue Teng; Zu, Zhao Hui; Ju, Rong; Guo, Minzhe; Wang, Xiu Mei; Xu, Qun; Cui, Fu Zhai

doi:10.1007/s11095-011-0452-3

Cited by 114 publications

(83 citation statements)

References 25 publications

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“…This was attributed to the fact that released factors might have remained in the hydrogel during the cross-link processing leading to the diffusion through the hydrogel matrix. However, the cumulative amount of bioactive release was reduced to 12% and 13% of total loading as compared to 20-30% in case of microspheres alone which was postulated to be due to the presence of the surrounding HA hydrogel as a delayed or deposited effect on the release profile of the biofactors [17].…”

Section: Hydrogel Scaffold and Microspheres For Supporting Survival Omentioning

confidence: 88%

Processing and Templating of Bioactive-Loaded Polymeric Neural Architectures: Challenges and Innovative Strategies

Pillay¹,

Kumar²,

Choonara³

et al. 2012

Recent Advances in Novel Drug Carrier Systems

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Section: Hydrogel Scaffold and Microspheres For Supporting Survival Omentioning

confidence: 88%

Processing and Templating of Bioactive-Loaded Polymeric Neural Architectures: Challenges and Innovative Strategies

Pillay¹,

Kumar²,

Choonara³

et al. 2012

Recent Advances in Novel Drug Carrier Systems

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“…Hence, HA hydrogels had the potential to be ideal carriers of BDNF. Recently, our group reported the effect of using PLGA microspheres as carriers for growth factors [112]. VEGF and BDNF were incorporated into PLGA microspheres by a water-in-oil-in-water emulsion technique, and PLGA microspheres were distributed in HA solution before gelation.…”

Section: Modification Of Hyaluronic Acid Hydrogelsmentioning

confidence: 99%

Hyaluronic acid-based scaffold for central neural tissue engineering

Wang

et al. 2012

Interface Focus.

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129

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Central nervous system (CNS) regeneration with central neuronal connections and restoration of synaptic connections has been a long-standing worldwide problem and, to date, no effective clinical therapies are widely accepted for CNS injuries. The limited regenerative capacity of the CNS results from the growth-inhibitory environment that impedes the regrowth of axons. Central neural tissue engineering has attracted extensive attention from multi-disciplinary scientists in recent years, and many studies have been carried out to develop cell-and regenerationactivating biomaterial scaffolds that create an artificial micro-environment suitable for axonal regeneration. Among all the biomaterials, hyaluronic acid (HA) is a promising candidate for central neural tissue engineering because of its unique physico-chemical and biological properties. This review attempts to outline current biomaterials-based strategies for CNS regeneration from a tissue engineering point of view and discusses the main progresses in research of HA-based scaffolds for central neural tissue engineering in detail.

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“…are ideal platforms materials for interfacial delivery of NTFs to abnormal tissues in various neural disease treatments; 2) Interfacial surface guidance: processable biopolymers can be fabricated into aligned structures at different scales, including nanofibers [26][27][28] , microfibers [18,19] , microlines [20,21] and micro-tunnels [29,30] , to influence interfacial interactions between neural cells/tissues and surfaces; 3) Interfacial electrical stimulation (ES): ES could be applied on the surface of nerve cells via biocompatible conducting polymers (CPs) platforms to enhance nerve cell proliferation and neurites outgrowth [22] ; 4) Interfacial molecules decoration:…”

mentioning

confidence: 99%

“…recent research revealed that the combinations of these stimulation methods can further improve the interfacial interactions between lesion cells/tissues and polymer based biomaterials, as well as the effects of nerve diseases treatments [29,32] .…”

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confidence: 99%

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Bio‐Interface of Conducting Polymer‐Based Materials for Neuroregeneration

Weng

Diao

et al. 2015

Adv Materials Inter

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Nerve system diseases like Parkinson's disease, Huntington's disease, Alzheimer's disease, etc. seriously affect thousands of patients' lives every year, making them suffer from pains and inconvenience. Recently, biointerfaces between neural cells/tissues and polymer based biomaterials attracted worldwide attention due to the ability of polymer based biomaterials to serve as nerve conduits, drug carriers and neurites guidance platform in neuroregeneration. The role that bio-interface played and the way it interacted with neural tissues and cells have been thoroughly investigated by the researchers. In this paper we mainly focus on reviewing the bio-interface between nerve tissues/cells and advanced functional biocompatible polymers, such as conducting polymers and advanced carbon composite materials. These advanced polymers can provide combined interfacial stimulations including interfacial external neurotrophic factors (NTFs) delivery, electrical stimulation, surface guidance and molecules decoration to lesion cells and tissues to promote neuroregeneration in vitro and in vivo, and have contributed greatly to nerve diseases therapy. At the end of this review, the criteria of polymer based biomaterials utilized in neuroregeneration are summarized and the perspectives for future development of bio-interfaces are also discussed. Nerve system diseases like Parkinson's disease, Huntington's disease and Alzheimer's disease etc. seriously affect thousands of patients' lives every year, making the patients suffer from pains and inconvenience brought about by these diseases. Recently, bio-interface between neural cells/tissues and polymer based biomaterials attracted worldwide attention due to the ability of polymer based biomaterials to serve as nerve conduits, drug carrier and neurites guidance platform in neuroregeneration. The role that bio-interface played and the way it interacted with neural tissues and cells have been thoroughly investigated by the researchers.In this paper we mainly focus on reviewing bio-interface between nerve tissues/cells and advanced functional biocompatible polymers, such as conducting polymers and advanced carbon composites materials.. These advanced polymers can provide combined interfacial stimulations including interfacial NTFs delivery, electrical stimulation, surface guidance and molecules decoration to lesion cells and tissues to promote neuroregeneration in vitro and in vivo, and have contributed greatly to nerve diseases therapy. At the end of this review, the criteria of polymer based biomaterials utilized in neuroregeneration are summarized and the perspectives for future development of bio-interfaces are also discussed.

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Combination of Hyaluronic Acid Hydrogel Scaffold and PLGA Microspheres for Supporting Survival of Neural Stem Cells

Abstract: Our created HA hydrogel/PLGA microsphere systems have a good potential for controlled delivery of varied biofactors and supporting NSCs for brain repair and implantation.

Cited by 114 publications

References 25 publications

Processing and Templating of Bioactive-Loaded Polymeric Neural Architectures: Challenges and Innovative Strategies

Processing and Templating of Bioactive-Loaded Polymeric Neural Architectures: Challenges and Innovative Strategies

Hyaluronic acid-based scaffold for central neural tissue engineering

Bio‐Interface of Conducting Polymer‐Based Materials for Neuroregeneration

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