Combination of Houttuynia cordata polysaccharide and Lactiplantibacillus plantarumP101 alleviates acute liver injury by regulating gut microbiota in mice

Abstract

BACKGROUND: Polysaccharides and probiotics can play an outstanding role in the treatment of liver disease by regulating gut microbiota. Recently, the combined therapeutic effect of probiotics and polysaccharides has attracted the attention of researchers. Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101 was used to prevent carbon tetrachloride (CCl 4 )-induced acute liver injury (ALI) in mice, and its effect on gut microbiota regulation was explored.RESULTS: Results showed that, in mice, HCP combined with L. plantarum P101 significantly alleviated oxidative stress and inflammatory injury in the liver by activating Nrf2 signals and inhibiting NF-κB signals. The analysis of gut microbiota revealed that the combination of HCP and L. plantarum P101 increased the abundance of beneficial bacteria such as Alloprevotella, Roseburia, and Akkermansia, but reduced that of the pro-inflammatory bacteria Alistipes, Enterorhabdus, Anaerotruncus, and Escherichia-Shigella. Correlation analysis also indicated that the expression of Nrf2 and TLR4/NF-κB was connected to the changes in gut microbiota composition. Houttuynia cordata polysaccharide combined with L. plantarum P101 can regulate the gut microbiota and then mediate the gut-liver axis to activate the antioxidant pathway and inhibit inflammatory responses, thereby alleviating CCl 4 -induced ALI.CONCLUSION: Our study provided a new perspective on the use of polysaccharides combined with probiotics in the treatment of liver disease.

β‐Glucan alleviates mice with ulcerative colitis through interactions between gut microbes and amino acids metabolism

“…1(B), IL‐10 levels were significantly decreased ( P < 0.05) in model mice compared to control mice, whereas they were significantly increased in UC mice treated with OBG. Houttuynia cordata polysaccharide can alleviate intestinal inflammation via gut microbiota, 27 which suggests that OBG can alleviate UC through modulation of the immune response.…”

High‐fat diet in mice led to increased severity of spermatogenesis impairment by lead exposure: perspective from gut microbiota and the efficacy of probiotics

“…The probiotic strain used in this work was Lactobacillus plantarum P101, which was isolated from Chinese traditional pickled cabbage, and its probiotic properties have been systematically evaluated 26 . This strain has been conserved under conservation number CCTCC M 2021108 at the China Center for Type Culture Collection since 2021.…”

Indole-3-acetamide from gut microbiota activated hepatic AhR and mediated the remission effect of Lactiplantibacillus plantarum P101 on alcoholic liver injury in mice

“…In previous studies, L. plantarum P101 has been demonstrated to prevent oxidative damage in mouse liver induced by CCl 4 or cyclophosphamide, as well as mitigate liver or sperm damage induced by lead in obese mice. 17–20 This study aimed to investigate the ability of L. plantarum P101 to alleviate alcohol-induced liver injury in mice and to further identify the key metabolites of the gut microbiome mediated by L. plantarum P101. These findings provide a deeper understanding of the influence of gut microbiota and their derivatives on the health and homeostasis of extraintestinal organs.…”