Combination of Immunotherapy and Photo‐pyroptosis as Novel Anticancer Strategy

Dao, Anyi; Yadav, Ashish Kumar; Wei, Li; Banerjee, Samya; Huang, Huaiyi

doi:10.1002/cbic.202200201

Cited by 8 publications

(5 citation statements)

References 18 publications

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“…Similarly to apoptosis, pyroptosis is induced by ROS produced during PDT with additional systemic immune responses toward solid tumors. As enhancement of systemic immune responses is crucial in anticancer PDT treatment, new types of PSs with the ability to invoke pyroptosis rather than apoptosis have been introduced in this field 313,314 …”

Section: Drawbacks In Pdtmentioning

confidence: 99%

“…As enhancement of systemic immune responses is crucial in anticancer PDT treatment, new types of PSs with the ability to invoke pyroptosis rather than apoptosis have been introduced in this field. 313,314 Contrary to ferroptosis, pyroptosis is initiated by participation of ROS-activating inflammasomes followed by triggering pyroptosis-specific inflammatory caspases which cause the cleavage of gasdermin-D. 315 With the following release and translocation of gasdermin-D N-terminal domain, pores are formed on the cell membrane, which leads to cell death processes such as cell swelling, membrane disruption, or immunostimulatory release of cellular content. 313,316 Importantly, the formation of pores on cell membranes is driven by released N-terminal domain binding with membrane phospholipids.…”

Section: Pyroptosis-inducing Psmentioning

confidence: 99%

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Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments

Kolarikova

Hošíková

Dilenko

et al. 2023

Medicinal Research Reviews

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Photodynamic therapy is an alternative treatment mainly for cancer but also for bacterial infections. This treatment dates back to 1900 when a German medical school graduate Oscar Raab found a photodynamic effect while doing research for his doctoral dissertation with Professor Hermann von Tappeiner. Unexpectedly, Raab revealed that the toxicity of acridine on paramecium depends on the intensity of light in his laboratory. Photodynamic therapy is therefore based on the administration of a photosensitizer with subsequent light irradiation within the absorption maxima of this substance followed by reactive oxygen species formation and finally cell death. Although this treatment is not a novelty, there is an endeavor for various modifications to the therapy. For example, selectivity and efficiency of the photosensitizer, as well as irradiation with various types of light sources are still being modified to improve final results of the photodynamic therapy. The main aim of this review is to summarize anticancer and antibacterial modifications, namely various compounds, approaches, and techniques, to enhance the effectiveness of photodynamic therapy.

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Section: Drawbacks In Pdtmentioning

confidence: 99%

Section: Pyroptosis-inducing Psmentioning

confidence: 99%

Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments

Kolarikova

Hošíková

Dilenko

et al. 2023

Medicinal Research Reviews

View full text Add to dashboard Cite

show abstract

“…Innovations such as bionic nanoparticles, which synergize indocyanine green and decitabine to trigger pyroptosis, have shown to attenuate immunosuppression and bolster systemic immunity, effectively combating primary and metastatic tumors ( 115 ). Additionally, the generation of reactive oxygen species (ROS) during photodynamic therapy (PDT) has been identified as a potent inducer of pyroptosis, with new photosensitizers capable of triggering immunogenic cancer cell pyroptosis, broadening the horizon for PDT applications ( 116 , 117 ).…”

Section: Summary and Prospectmentioning

confidence: 99%

Unlocking the potential of pyroptosis in tumor immunotherapy: a new horizon in cancer treatment

Yin,

Song,

Bian

et al. 2024

Front. Immunol.

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BackgroundThe interaction between pyroptosis—a form of programmed cell death—and tumor immunity represents a burgeoning field of interest. Pyroptosis exhibits a dual role in cancer: it can both promote tumor development and counteract it by activating immune responses that inhibit tumor evasion and encourage cell death. Current tumor immunotherapy strategies, notably CAR-T cell therapy and immune checkpoint inhibitors (ICIs), alongside the potential of certain traditional Chinese medicinal compounds, highlight the intricate relationship between pyroptosis and cancer immunity. As research delves deeper into pyroptosis mechanisms within tumor therapy, its application in enhancing tumor immune responses emerges as a novel research avenue.PurposeThis review aims to elucidate the mechanisms underlying pyroptosis, its impact on tumor biology, and the advancements in tumor immunotherapy research.MethodsA comprehensive literature review was conducted across PubMed, Embase, CNKI, and Wanfang Database from the inception of the study until August 22, 2023. The search employed keywords such as “pyroptosis”, “cancer”, “tumor”, “mechanism”, “immunity”, “gasdermin”, “ICB”, “CAR-T”, “PD-1”, “PD-L1”, “herbal medicine”, “botanical medicine”, “Chinese medicine”, “traditional Chinese medicine”, “immunotherapy”, linked by AND/OR, to capture the latest findings in pyroptosis and tumor immunotherapy.ResultsPyroptosis is governed by a complex mechanism, with the Gasdermin family playing a pivotal role. While promising for tumor immunotherapy application, research into pyroptosis’s effect on tumor immunity is still evolving. Notably, certain traditional Chinese medicine ingredients have been identified as potential pyroptosis inducers, meriting further exploration.ConclusionThis review consolidates current knowledge on pyroptosis’s role in tumor immunotherapy. It reveals pyroptosis as a beneficial factor in the immunotherapeutic landscape, suggesting that leveraging pyroptosis for developing novel cancer treatment strategies, including those involving traditional Chinese medicine, represents a forward-looking approach in oncology.

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“…[18][19][20][21] It is known that in the ICD process, damage-associated molecular patterns (DAMPs) can induce the expression of calreticulin (CRT) and heat shock protein 90 (HSP 90), as well as secretion or release of high mobility group box 1 (HMGB1) and ATP. [4,16,[22][23][24][25][26] These antigen signals are captured and identified by dendritic cells and macrophages. After processing, it was presented to adaptive immune cells, thus activating the anti-tumor immune response of the body.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Reprogramming Strategy of Tumor Microenvironment for Rejuvenating Photosensitizers‐Mediated Photodynamic Therapy

Yu,

Li,

Wang

et al. 2023

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Photodynamic therapy (PDT) has recently been considered a potential tumor therapy due to its time‐space specificity and non‐invasive advantages. PDT can not only directly kill tumor cells by using cytotoxic reactive oxygen species but also induce an anti‐tumor immune response by causing immunogenic cell death of tumor cells. Although it exhibits a promising prospect in treating tumors, there are still many problems to be solved in its practical application. Tumor hypoxia and immunosuppressive microenvironment seriously affect the efficacy of PDT. The hypoxic and immunosuppressive microenvironment is mainly due to the abnormal vascular matrix around the tumor, its abnormal metabolism, and the influence of various immunosuppressive‐related cells and their expressed molecules. Thus, reprogramming the tumor microenvironment (TME) is of great significance for rejuvenating PDT. This article reviews the latest strategies for rejuvenating PDT, from regulating tumor vascular matrix, interfering with tumor cell metabolism, and reprogramming immunosuppressive related cells and factors to reverse tumor hypoxia and immunosuppressive microenvironment. These strategies provide valuable information for a better understanding of the significance of TME in PDT and also guide the development of the next‐generation multifunctional nanoplatforms for PDT.

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Combination of Immunotherapy and Photo‐pyroptosis as Novel Anticancer Strategy

Cited by 8 publications

References 18 publications

Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments

Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments

Unlocking the potential of pyroptosis in tumor immunotherapy: a new horizon in cancer treatment

Recent Advances in Reprogramming Strategy of Tumor Microenvironment for Rejuvenating Photosensitizers‐Mediated Photodynamic Therapy

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