2022
DOI: 10.1016/j.celrep.2022.110825
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Combination of in vivo phage therapy data with in silico model highlights key parameters for pneumonia treatment efficacy

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Cited by 31 publications
(24 citation statements)
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“…This suggests that the animal host does not influence this selection process. However, the acute pneumonia model imposes limitations such as the use of a large bacterial population to initiate a fatal infection by overwhelming the immune system, as well as a large phage dose to provide a rapid and efficient treatment (48). It then remains possible that a putative impact of the animal host on phage resistance mechanisms could not been detected within this setting and may require extended time of observation.…”
Section: Discussionmentioning
confidence: 99%
“…This suggests that the animal host does not influence this selection process. However, the acute pneumonia model imposes limitations such as the use of a large bacterial population to initiate a fatal infection by overwhelming the immune system, as well as a large phage dose to provide a rapid and efficient treatment (48). It then remains possible that a putative impact of the animal host on phage resistance mechanisms could not been detected within this setting and may require extended time of observation.…”
Section: Discussionmentioning
confidence: 99%
“…Another limitation is the lack of loss of phages over time as they remained trapped in the same compartment of bacteria. However, the decay of phages in uninfected or infected lungs of mice was shown to be rather weak (below 1-log per day) compared to the overall density of phages in the HFIM [30]. The data presented here advocate in favor of a translation to clinics that could ultimately slow down the use of multiple antibiotics and therefore, the selection of MDR strains [17].…”
Section: Discussionmentioning
confidence: 99%
“…Mathematical models are crucial tools in advancing our design of phage therapies ( Payne and Jansen 2001 ; Cairns et al. 2009 ; Delattre et al. 2022 ) by allowing us to extend molecular knowledge to population dynamics predictions.…”
Section: What Does Phenotypic Flux Mean For Phage Therapy?mentioning
confidence: 99%