Combination of kinematic analyses and diffusion tensor tractrography to evaluate the residual motor functions in spinal cord‐hemisected monkeys

Zhao, Chen; Song, Wei; Rao, Jia‐Sheng; Zhao, Wen; Wei, Ruihan; Zhou, Xia; Tian, Peng-Yu; Yang, Zhaoyang; Li, Xiaoguang

doi:10.1111/jmp.12276

Cited by 14 publications

(10 citation statements)

References 53 publications

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“…Parallel acquisition was used with an acceleration factor of 3 to limit the extent of susceptibility artifacts. A twice-refocused pulse sequence was used to minimize eddy current effects [ 25 , 26 ]. Saturation bands were set on the chest and abdomen to reduce physiological motion artifacts.…”

Section: Methodsmentioning

confidence: 99%

MRI metrics at the epicenter of spinal cord injury are correlated with the stepping process in rhesus monkeys

et al. 2022

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Clinical evaluations of long-term outcomes in the early-stage spinal cord injury (SCI) focus on macroscopic motor performance and are limited in their prognostic precision. This study was designed to investigate the sensitivity of the magnetic resonance imaging (MRI) indexes to the data-driven gait process after SCI. Ten adult female rhesus monkeys were subjected to thoracic SCI. Kinematics-based gait examinations were performed at 1 (early stage) and 12 (chronic stage) months post-SCI. The proportion of stepping (PS) and gait stability (GS) were calculated as the outcome measures. MRI metrics, which were derived from structural imaging (spinal cord cross-sectional area, SCA) and diffusion tensor imaging (fractional anisotropy, FA; axial diffusivity, λ // ), were acquired in the early stage and compared with functional outcomes by using correlation analysis and stepwise multivariable linear regression. Residual tissue SCA at the injury epicenter and residual tissue FA/remote normal-like tissue FA were correlated with the early-stage PS and GS. The extent of lesion site λ // /residual tissue λ // in the early stage after SCI was correlated with the chronic-stage GS. The ratios of lesion site λ // to residual tissue λ // and early-stage GS were predictive of the improvement in the PS at follow-up. Similarly, the ratios of lesion site λ // to residual tissue λ // and early-stage PS best predicted chronic GS recovery. Our findings demonstrate the predictive power of MRI combined with the early data-driven gait indexes for long-term outcomes. Such an approach may help clinicians to predict functional recovery accurately.

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Section: Methodsmentioning

confidence: 99%

MRI metrics at the epicenter of spinal cord injury are correlated with the stepping process in rhesus monkeys

et al. 2022

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“…此外, 更加具有意义的一个特点是, 非人灵长类能够在短距离内完成双足行走 [55] , 并展现出与人类双足行走极大的相似性 [56] . 双足行走能力是评估人类运动功能的一个重要方面 [57] .…”

Section: 3unclassified

Application of non-human primates’ behavioral research in the study of spinal cord injury

Rao¹,

Zhao²,

Zhao³

et al. 2021

Sci. Sin.-Vitae

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“…Diffusion tensor imaging (DTI), an effective noninvasive in vivo magnetic resonance imaging technique, can describe the orientation of white matter fiber tracts by measuring the free diffusion degree of water molecules under structural restraints and can quantitatively reflect the integrity of white matter tracts through multiple parameters . DTI can be very applicable for studying neurological lesions, and it has been applied to the in vivo evaluation of NHP brain and spinal cord lesions, proving its effectiveness and reliability.…”

Section: Introductionmentioning

confidence: 99%

Image correction for diffusion tensor imaging of Rhesus monkey thoracic spinal cord

Rao

Liu

Zhao

et al. 2019

J of Medical Primatology

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Background: The relatively tiny spinal cord of non-human primate (NHP) causes increased challenge in diffusion tensor imaging (DTI) post-processing. This study aimed to establish a reliable correction strategy applied to clinical DTI images of NHP. Methods: Six normal and partial spinal cord injury (SCI) rhesus monkeys underwent 3T MR scanning. A correction strategy combining multiple iterations and non-rigid deformation was used for DTI image post-processing. Quantitative evaluations were then conducted to investigate effects of distortion correction.Results: After correction, longitudinal geometric distortion, global distortion, and residual distance errors were all significantly decreased (P < 0.05). Fractional anisotropy at the injured site was remarkably lower than that at the contralateral site (P = 0.0488) and was substantially lower than those at the adjacent superior (P = 0.0157) and inferior (P = 0.0128) areas at the same side. Conclusions:Our image correction strategy can improve the quality of the DTI images of NHP thoracic cords, contributing to the development of SCI preclinical research. K E Y W O R D S image correction strategy, non-human primates, preclinical research, spinal cord injury | 321 RAO et Al.

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Combination of kinematic analyses and diffusion tensor tractrography to evaluate the residual motor functions in spinal cord‐hemisected monkeys

Abstract: The combinatory use of gait analysis and DTT has been demonstrated to be sensitive to locomotion changes after SCI, and may therefore have potential applications in the pre-clinical studies of SCI.

Cited by 14 publications

References 53 publications

MRI metrics at the epicenter of spinal cord injury are correlated with the stepping process in rhesus monkeys

MRI metrics at the epicenter of spinal cord injury are correlated with the stepping process in rhesus monkeys

Application of non-human primates’ behavioral research in the study of spinal cord injury

Image correction for diffusion tensor imaging of Rhesus monkey thoracic spinal cord

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Combination of kinematic analyses and diffusion tensor tractrography to evaluate the residual motor functions in spinal cord‐hemisected monkeys

Abstract: The combinatory use of gait analysis and DTT has been demonstrated to be sensitive to locomotion changes after SCI, and may therefore have potential applications in the pre-clinical studies of SCI.

Cited by 14 publications

References 53 publications

MRI metrics at the epicenter of spinal cord injury are correlated with the stepping process in rhesus monkeys

MRI metrics at the epicenter of spinal cord injury are correlated with the stepping process in rhesus monkeys

Application of non-human primates&rsquo; behavioral research in the study of spinal cord injury

Image correction for diffusion tensor imaging of Rhesus monkey thoracic spinal cord

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Product

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Application of non-human primates’ behavioral research in the study of spinal cord injury