Combination of Loperamide and Niacin modify DENA induced altered Liver enzymes

Abstract

Hepatocellular Carcinoma (HCC) is among the most lethal cancers which makes it the third most frequent cause of cancer related deaths. Diethylnitrosamine (DENA) is a potent initiator and hepatocarcinogen in rats. DENA induced Hepatocellular damage clearly demonstrates by the elevated levels of liver enzymes serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (ALP), and a-feto protein (AFP). This work is an attempt to test the hypothesis that Loperamide (5mg/kg) and Niacin in combination restores the DENA (160mg/kg) induced altered enzymes after single i.p administration in Wistar rats. The ability to alter the enzymes was measured by comparing biochemical serum markers and AFP. The results have confirmed the significant elevation of these parameters in DENA control group compared to normal control and the therapeutic groups. Therapeutic group significantly reveals that Loperamide and Niacin restores the altered hepatic enzymes towards the Normal. Key messages: Our data reveals and confirms that this remarkable combination possess the potential for the treatment of hepatocellular carcinomas in rats exposed to DENA. Administration of Loperamide + Niacin relatively improved the biochemical parameters to values approximating those of the normal controls.