Combination of nano-hydroxyapatite and curcumin in a biopolymer blend matrix: Characteristics and drug release performance of fibrous composite material systems

Eskitoros‐Togay, Ş. Melda; Bulbul, Y. Emre; Dilsiz, Nursel

doi:10.1016/j.ijpharm.2020.119933

Cited by 25 publications

(9 citation statements)

References 49 publications

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“…The encapsulation efficiency of curcumin in the electrospun membranes was 86–94%. The fiber membrane containing 0.3% HANPs showed a gradual increasing trend in the first hour of release and only reached 43% of curcumin released from the release time to the eighth hour, indicating that the controlled release of curcumin can be achieved in a simulated environment to prolong the action of the drug after implantation [ 96 ]. By varying the weight ratio of sodium alginate and gelatin (A/G = 40/60, 50/50, and 60/40) and adding different concentrations of HANPs (1, 2, 5, 10, and 20% w / w ) to the film solution, Türe (2019) et al explored whether the addition of HANPs alters the physical, mechanical, thermal, and antimicrobial properties of the films.…”

Section: Polymers–ha Composite As Carriers For Drug-sustained Releasementioning

confidence: 99%

Advances of Hydroxyapatite Hybrid Organic Composite Used as Drug or Protein Carriers for Biomedical Applications: A Review

et al. 2022

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Hydroxyapatite (HA), especially in the form of HA nanoparticles (HANPs), has excellent bioactivity, biodegradability, and osteoconductivity and therefore has been widely used as a template or additives for drug delivery in clinical applications, such as dentistry and orthopedic repair. Due to the atomically anisotropic distribution on the preferred growth of HA crystals, especially the nanoscale rod-/whisker-like morphology, HA can generally be a good candidate for carrying a variety of substances. HA is biocompatible and suitable for medical applications, but most drugs carried by HANPs have an initial burst release. In the adsorption mechanism of HA as a carrier, specific surface area, pore size, and porosity are important factors that mainly affect the adsorption and release amounts. At present, many studies have developed HA as a drug carrier with targeted effect, porous structure, and high porosity. This review mainly discusses the influence of HA structures as a carrier on the adsorption and release of active molecules. It then focuses on the benefits and effects of different types of polymer-HA composites to re-examine the proteins/drugs carry and release behavior and related potential clinical applications. This literature survey can be divided into three main parts: 1. interaction and adsorption mechanism of HA and drugs; 2. advantages and application fields of HA/organic composites; 3. loading and drug release behavior of multifunctional HA composites in different environments. This work also presents the latest development and future prospects of HA as a drug carrier.

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Section: Polymers–ha Composite As Carriers For Drug-sustained Releasementioning

confidence: 99%

Advances of Hydroxyapatite Hybrid Organic Composite Used as Drug or Protein Carriers for Biomedical Applications: A Review

et al. 2022

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“…%HAP-CCM, PCL/PEO/0.5 wt. %HAP-CCM [116]. W.-H. Lee et al also study this kind of composite, CCM-HAP but the surface of HAP was functionalized with different carboxylic acids to harbor negative charges and increase drug (CCM-NPs) loading capacity of HAP.…”

Section: Fig 2 Biomedical Applications Of the Interactions Between Hy...mentioning

confidence: 99%

Interaction of Bioactive Compounds With Ceramic Materials – A Review

PALTINEAN¹,

Tomoaia²,

RACZ³

et al. 2022

AnnalsARSciPhysChem

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This review examines the interaction between silymarin (SIL) and other plant-based bioactive compounds such as curcumin (CCM), piperine (PIP), resveratrol (RES), and icariin (ICA). Their combination revealed synergistic effects on colon (HCT116), breast (T47D) tumor cells, hepatocellular carcinoma, and periodontal disease. The review also addresses the interaction between these plant extracts with ceramic materials such as hydroxyapatite (HAP) and carotenoids with concrete examples of biomedical applications. Silymarin’s interaction with chemotherapeutic drugs (doxorubicin-DOX, paclitaxel-PCT and 5-Fluorouracil-5-FLU) and gold nanoparticles-GNPs and silver nanoparticles-SNPs is also debated. All these combinations can form composites of major importance in the biomedical field and to contribute significantly to orthopedic surgery where materials are needed for implants that face severe infections. This short review highlights the variety of multifunctional nanoparticles that open new opportunities in cancer treatment and the need to use the Langmuir Blodgett Technique that mimics the biological membrane and provides rich medical information.

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“…A nanofiber material with slow release rate of curcumin and with a high cytotoxicity against breast cancer cell line [216] Chitosan/pullulan carried by a shell of polylactic acid (PLA)…”

Section: Drug Deliverymentioning

confidence: 99%

Electrospun Nanofibrous Scaffolds: Review of Current Progress in the Properties and Manufacturing Process, and Possible Applications for COVID-19

et al. 2021

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Over the last twenty years, researchers have focused on the potential applications of electrospinning, especially its scalability and versatility. Specifically, electrospun nanofiber scaffolds are considered an emergent technology and a promising approach that can be applied to biosensing, drug delivery, soft and hard tissue repair and regeneration, and wound healing. Several parameters control the functional scaffolds, such as fiber geometrical characteristics and alignment, architecture, etc. As it is based on nanotechnology, the concept of this approach has shown a strong evolution in terms of the forms of the materials used (aerogels, microspheres, etc.), the incorporated microorganisms used to treat diseases (cells, proteins, nuclei acids, etc.), and the manufacturing process in relation to the control of adhesion, proliferation, and differentiation of the mimetic nanofibers. However, several difficulties are still considered as huge challenges for scientists to overcome in relation to scaffolds design and properties (hydrophilicity, biodegradability, and biocompatibility) but also in relation to transferring biological nanofibers products into practical industrial use by way of a highly efficient bio-solution. In this article, the authors review current progress in the materials and processes used by the electrospinning technique to develop novel fibrous scaffolds with suitable design and that more closely mimic structure. A specific interest will be given to the use of this approach as an emergent technology for the treatment of bacteria and viruses such as COVID-19.

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Combination of nano-hydroxyapatite and curcumin in a biopolymer blend matrix: Characteristics and drug release performance of fibrous composite material systems

Cited by 25 publications

References 49 publications

Advances of Hydroxyapatite Hybrid Organic Composite Used as Drug or Protein Carriers for Biomedical Applications: A Review

Advances of Hydroxyapatite Hybrid Organic Composite Used as Drug or Protein Carriers for Biomedical Applications: A Review

Interaction of Bioactive Compounds With Ceramic Materials – A Review

Electrospun Nanofibrous Scaffolds: Review of Current Progress in the Properties and Manufacturing Process, and Possible Applications for COVID-19

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